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J Biol Chem, Vol. 275, Issue 2, 1152-1160, January 14, 2000
From the Center for Ophthalmic Research and
§ Cerebrovascular and NeuroScience Research Institute,
Brigham & Women's Hospital, Department of Ophthalmology, Harvard
Medical School, Boston, Massachusetts 02115 and the
RX, a homeodomain-containing protein essential
for proper eye development (Mathers, P. H. Grinberg, A., Mahon,
K. A., and Jamrich, M. (1997) Nature 387, 603-607),
binds to the photoreceptor conserved element-1 (PCE-1/Ret 1) in the
photoreceptor cell-specific arrestin promoter and stimulates gene
expression. RX is found in many retinal cell types including
photoreceptor cells. Another homeodomain-containing protein, CRX, which
binds to the OTX element to stimulate promoter activity, is found
exclusively in photoreceptor cells (Chen, S., Wang, Q. L., Nie,
Z., Sun, H., Lennon, G., Copeland, N. G., Gillbert, D. J. Jenkins, N. A., and Zack, D. J. (1997) Neuron 19, 1017-1030; Furukawa, T., Morrow, E. M., and Cepko, C. L. (1997) Cell 91, 531-541). Binding assay and cell culture studies indicate that both PCE-1 and OTX elements and at least two
different regulatory factors RX and CRX are necessary for high level,
photoreceptor cell-restricted gene expression. Thus, photoreceptor
specificity can be achieved by multiple promoter elements interacting
with a combination of both photoreceptor-specific regulatory factors
and factors present in closely related cell lineages.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF115392.
Both PCE-1/RX and OTX/CRX Interactions Are Necessary for
Photoreceptor-specific Gene Expression*
, Laboratory of Molecular and Developmental Biology, NEI,
National Institutes of Health, Bethesda, Maryland 20892
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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