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J Biol Chem, Vol. 275, Issue 2, 1169-1175, January 14, 2000

Four New Members Expand the Interleukin-1 Superfamily*

Dirk E. Smith, Blair R. Renshaw, Randal R. Ketchem, Marek Kubin, Kirsten E. Garka, and John E. SimsDagger

From Immunex Corp., Seattle, Washington 98101

We report here the cloning and characterization of four new members of the interleukin-1 (IL-1) family (FIL1delta , FIL1epsilon , FIL1zeta , and FIL1eta , with FIL1 standing for "Family of IL-1"). The novel genes demonstrate significant sequence similarity to IL-1alpha , IL-1beta , IL-1ra, and IL-18, and in addition maintain a conserved exon-intron arrangement that is shared with the previously known members of the family. Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

The nucleotide sequences reported in this paper for FIL1delta , FIL1epsilon , FIL1zeta , and FIL1eta have been deposited in GenBankTM with accession numbers AF201830, AF201831, AF201832, and AF201833.

Dagger To whom correspondence should be addressed: Immunex Corp., 51 University St., Seattle, WA 98101. Tel.: 206-389-4005; Fax: 206-233-9733; E-mail: sims@immunex.com.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
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