| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 2, 1216-1225, January 14, 2000
From the Prostate cancer, the most frequent solid
cancer in older men, is a leading cause of cancer deaths. Although
proliferation and differentiation of normal prostate epithelia and the
initial growth of prostate cancer cells are
androgen-dependent, prostate cancers ultimately become
androgen-independent and refractory to hormone therapy. The
prostate-specific antigen (PSA) gene has been widely used as a
diagnostic indicator for androgen-dependent and
-independent prostate cancer. Androgen-induced and prostate epithelium-specific PSA expression is regulated by a proximal promoter
and an upstream enhancer via several androgen receptor binding sites.
However, little progress has been made in identifying androgen-independent regulatory elements involved in PSA gene regulation. We report the isolation of a novel, prostate
epithelium-specific Ets transcription factor, PDEF
(prostate-derived Ets
factor), that among the Ets family uniquely prefers binding
to a GGAT rather than a GGAA core. PDEF acts as an androgen-independent
transcriptional activator of the PSA promoter. PDEF also directly
interacts with the DNA binding domain of androgen receptor and enhances
androgen-mediated activation of the PSA promoter. Our results, as well
as the critical roles of other Ets factors in cellular differentiation
and tumorigenesis, strongly suggest that PDEF is an important regulator
of prostate gland and/or prostate cancer development.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF071538.
PDEF, a Novel Prostate Epithelium-specific Ets Transcription
Factor, Interacts with the Androgen Receptor and Activates
Prostate-specific Antigen Gene Expression*
,,,,,,,,
,**,,, and§§
New England Baptist Bone and Joint
Institute, Beth Israel Deaconess Medical Center and Harvard Medical
School, Boston, Massachusetts 02115, the § Department of
Surgery and Genetics, Stanford University School of Medicine, Stanford,
California 94305, the ¶ Division of Pathology, Beth Israel
Deaconess Medical Center and Harvard Medical School, Boston,
Massachusetts 02215, the Department of Biology, University of
York, P.O. Box 373, York YO1 5YW, United Kingdom, and
Human Genome Sciences, Inc.,
Rockville, Maryland 20850
*
This work was supported by a CaP CURE award (to T. A. L.) and by National Institutes of Health Grant KO8/CA 71429 (to
P. O.)The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K.-H. Tsui, T.-H. Feng, C.-M. Lin, P.-L. Chang, and H.-H. Juang Curcumin Blocks the Activation of Androgen and Interlukin-6 on Prostate-Specific Antigen Expression in Human Prostatic Carcinoma Cells J Androl, November 1, 2008; 29(6): 661 - 668. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. J. Findlay, D. P. Turner, O. Moussa, and D. K. Watson MicroRNA-Mediated Inhibition of Prostate-Derived Ets Factor Messenger RNA Translation Affects Prostate-Derived Ets Factor Regulatory Networks in Human Breast Cancer Cancer Res., October 15, 2008; 68(20): 8499 - 8506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Zhang, R. A. Fillmore, and W. E. Zimmer Structural and Functional Analysis of Domains Mediating Interaction Between the Bagpipe Homologue, Nkx3.1 and Serum Response Factor Experimental Biology and Medicine, March 1, 2008; 233(3): 297 - 309. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. V. Heemers and D. J. Tindall Androgen Receptor (AR) Coregulators: A Diversity of Functions Converging on and Regulating the AR Transcriptional Complex Endocr. Rev., December 1, 2007; 28(7): 778 - 808. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Gu, L. F. Zerbini, H. H. Otu, M. Bhasin, Q. Yang, M. G. Joseph, F. Grall, T. Onatunde, R. G. Correa, and T. A. Libermann Reduced PDEF Expression Increases Invasion and Expression of Mesenchymal Genes in Prostate Cancer Cells Cancer Res., May 1, 2007; 67(9): 4219 - 4226. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Lacroix Significance, detection and markers of disseminated breast cancer cells Endocr. Relat. Cancer, December 1, 2006; 13(4): 1033 - 1067. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Zhou, H. Wu, P. Lee, and Z. Wang Roles of the androgen receptor cofactor p44 in the growth of prostate epithelial cells. J. Mol. Endocrinol., October 1, 2006; 37(2): 283 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yu, K. Suzuki, Y. Wang, A. Gupta, R. Jin, M.-C. Orgebin-Crist, and R. Matusik The Role of Forkhead Box A2 to Restrict Androgen-Regulated Gene Expression of Lipocalin 5 in the Mouse Epididymis Mol. Endocrinol., October 1, 2006; 20(10): 2418 - 2431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gao, H. Wang, P. Lee, J. Melamed, C. X Li, F. Zhang, H. Wu, L. Zhou, and Z. Wang Androgen receptor and prostate apoptosis response factor-4 target the c-FLIP gene to determine survival and apoptosis in the prostate gland. J. Mol. Endocrinol., June 1, 2006; 36(3): 463 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mimeault and S. K. Batra Recent advances on multiple tumorigenic cascades involved in prostatic cancer progression and targeting therapies Carcinogenesis, January 1, 2006; 27(1): 1 - 22. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. Gunawardane, D. C. Sgroi, C. N. Wrobel, E. Koh, G. Q. Daley, and J. S. Brugge Novel Role for PDEF in Epithelial Cell Migration and Invasion Cancer Res., December 15, 2005; 65(24): 11572 - 11580. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C-L Hsieh, Z Xie, Z-Y Liu, J E Green, W D Martin, M W Datta, F Yeung, D Pan, and L W K Chung A luciferase transgenic mouse model: visualization of prostate development and its androgen responsiveness in live animals J. Mol. Endocrinol., October 1, 2005; 35(2): 293 - 304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. P Dwivedi, P. H Anderson, J. L Omdahl, H L. Grimes, H. A Morris, and B. K May Identification of growth factor independent-1 (GFI1) as a repressor of 25-hydroxyvitamin D 1-alpha hydroxylase (CYP27B1) gene expression in human prostate cancer cells Endocr. Relat. Cancer, June 1, 2005; 12(2): 351 - 365. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Yuan, A. Gong, and C. Y.F. Young Involvement of transcription factor Sp1 in quercetin-mediated inhibitory effect on the androgen receptor in human prostate cancer cells Carcinogenesis, April 1, 2005; 26(4): 793 - 801. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mitas, J. S. Almeida, K. Mikhitarian, W. E. Gillanders, D. N. Lewin, D. D. Spyropoulos, L. Hoover, A. Graham, T. Glenn, P. King, et al. Accurate Discrimination of Barrett's Esophagus and Esophageal Adenocarcinoma Using a Quantitative Three-Tiered Algorithm and Multimarker Real-time Reverse Transcription-PCR Clin. Cancer Res., March 15, 2005; 11(6): 2205 - 2214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. J. Edwards, I. M. Berquin, H. Sun, J. T. O'Flaherty, L. W. Daniel, M. J. Thomas, L. L. Rudel, R. L. Wykle, and Y. Q. Chen Differential Effects of Delivery of Omega-3 Fatty Acids to Human Cancer Cells by Low-Density Lipoproteins versus Albumin Clin. Cancer Res., December 15, 2004; 10(24): 8275 - 8283. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. C. Hollenhorst, D. A. Jones, and B. J. Graves Expression profiles frame the promoter specificity dilemma of the ETS family of transcription factors Nucleic Acids Res., October 21, 2004; 32(18): 5693 - 5702. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fujii, S. Kawakami, Y. Okada, Y. Kageyama, and K. Kihara Regulation of prostate-specific antigen by activin A in prostate cancer LNCaP cells Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E927 - E931. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Koga, Y. Horio, T. Mitsudomi, T. Takahashi, and Y. Yatabe Identification of MGB1 as a Marker in the Differential Diagnosis of Lung Tumors in Patients with a History of Breast Cancer by Analysis of Publicly Available SAGE Data J. Mol. Diagn., May 1, 2004; 6(2): 90 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Wang, T. S. Udayakumar, T. S. Vasaitis, A. M. Brodie, and J. D. Fondell Mechanistic Relationship between Androgen Receptor Polyglutamine Tract Truncation and Androgen-dependent Transcriptional Hyperactivity in Prostate Cancer Cells J. Biol. Chem., April 23, 2004; 279(17): 17319 - 17328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Heinlein and C. Chang Androgen Receptor in Prostate Cancer Endocr. Rev., April 1, 2004; 25(2): 276 - 308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mitas, L. Hoover, G. Silvestri, C. Reed, M. Green, A. T. Turrisi, C. Sherman, K. Mikhitarian, D. J. Cole, M. I. Block, et al. Lunx Is a Superior Molecular Marker for Detection of Non-Small Lung Cell Cancer in Peripheral Blood J. Mol. Diagn., November 1, 2003; 5(4): 237 - 242. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Gao, J. Zhang, M. A. Rao, T. C. Case, J. Mirosevich, Y. Wang, R. Jin, A. Gupta, P. S. Rennie, and R. J. Matusik The Role of Hepatocyte Nuclear Factor-3{alpha} (Forkhead Box A1) and Androgen Receptor in Transcriptional Regulation of Prostatic Genes Mol. Endocrinol., August 1, 2003; 17(8): 1484 - 1507. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-S. Cheng, V. Giandomenico, I. Pastan, and M. Essand Characterization of the Androgen-Regulated Prostate-Specific T Cell Receptor {gamma}-Chain Alternate Reading Frame Protein (TARP) Promoter Endocrinology, August 1, 2003; 144(8): 3433 - 3440. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Herness and R. K. Naz A Novel Human Prostate-specific Gene-1 (HPG-1): Molecular Cloning, Sequencing, and Its Potential Involvement in Prostate Carcinogenesis Cancer Res., January 15, 2003; 63(2): 329 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. P. Balk, Y.-J. Ko, and G. J. Bubley Biology of Prostate-Specific Antigen J. Clin. Oncol., January 15, 2003; 21(2): 383 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Johnson, R. P. Walker, S. W. Jones, K. Stephens, J. Meurer, D. A. Zajchowski, M. M. Luke, F. Eeckman, Y. Tan, L. Wong, et al. Multiplex Gene Expression Analysis for High-Throughput Drug Discovery: Screening and Analysis of Compounds Affecting Genes Overexpressed in Cancer Cells Mol. Cancer Ther., December 1, 2002; 1(14): 1293 - 1304. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. I. Jobling, Z. Fang, D. Koleski, and M. J. Tymms Expression of the ETS Transcription Factor ELF3 in the Retinal Pigment Epithelium Invest. Ophthalmol. Vis. Sci., November 1, 2002; 43(11): 3530 - 3537. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. G. R. Thompson, J. W. Harris, B. J. Wold, S. R. Quake, and J. P. Brody Identification and Confirmation of a Module of Coexpressed Genes Genome Res., October 1, 2002; 12(10): 1517 - 1522. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Jain, A. Lam, I. Vivanco, M. F. Carey, and R. E. Reiter Identification of an Androgen-Dependent Enhancer within the Prostate Stem Cell Antigen Gene Mol. Endocrinol., October 1, 2002; 16(10): 2323 - 2337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Qi, C. Fillion, Y. Labrie, J. Grenier, A. Fournier, L. Berger, M. El-Alfy, and C. Labrie AIbZIP, a Novel bZIP Gene Located on Chromosome 1q21.3 That Is Highly Expressed in Prostate Tumors and of Which the Expression Is Up-Regulated by Androgens in LNCaP Human Prostate Cancer Cells Cancer Res., February 1, 2002; 62(3): 721 - 733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, A. K. Nandi, X. Li, and C. J. Bieberich NKX-3.1 Interacts with Prostate-derived Ets Factor and Regulates the Activity of the PSA Promoter Cancer Res., January 1, 2002; 62(2): 338 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Yuan, M. L. Lu, T. Li, and S. P. Balk SRY Interacts with and Negatively Regulates Androgen Receptor Transcriptional Activity J. Biol. Chem., November 30, 2001; 276(49): 46647 - 46654. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Shenk, C. J. Fisher, S.-Y. Chen, X.-F. Zhou, K. Tillman, and L. Shemshedini p53 Represses Androgen-induced Transactivation of Prostate-specific Antigen by Disrupting hAR Amino- to Carboxyl-terminal Interaction J. Biol. Chem., October 12, 2001; 276(42): 38472 - 38479. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Cinar, K. S. Koeneman, M. Edlund, G. S. Prins, H. E. Zhau, and L. W. K. Chung Androgen Receptor Mediates the Reduced Tumor Growth, Enhanced Androgen Responsiveness, and Selected Target Gene Transactivation in a Human Prostate Cancer Cell Line Cancer Res., October 1, 2001; 61(19): 7310 - 7317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ghadersohi and A. K. Sood Prostate Epithelium-derived Ets Transcription Factor mRNA Is Overexpressed in Human Breast Tumors and Is A Candidate Breast Tumor Marker and A Breast Tumor Antigen Clin. Cancer Res., September 1, 2001; 7(9): 2731 - 2738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yang, G. E. Holt, M. P. Velders, E. D. Kwon, and W. M. Kast Murine Six-Transmembrane Epithelial Antigen of the Prostate, Prostate Stem Cell Antigen, and Prostate-specific Membrane Antigen: Prostate-specific Cell-Surface Antigens Highly Expressed in Prostate Cancer of Transgenic Adenocarcinoma Mouse Prostate Mice Cancer Res., August 1, 2001; 61(15): 5857 - 5860. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. de Pinieux, M.-E. Legrier, F. Poirson-Bichat, Y. Courty, R. Bras-Goncalves, A.-M. Dutrillaux, F. Nemati, S. Oudard, R. Lidereau, P. Broqua, et al. Clinical and Experimental Progression of a New Model of Human Prostate Cancer and Therapeutic Approach Am. J. Pathol., August 1, 2001; 159(2): 753 - 764. [Abstract] [Full Text]
|
|
|
|
|
|
M. J. Linja, K. J. Savinainen, O. R. Saramäki, T. L. J. Tammela, R. L. Vessella, and T. Visakorpi Amplification and Overexpression of Androgen Receptor Gene in Hormone-Refractory Prostate Cancer Cancer Res., May 1, 2001; 61(9): 3550 - 3555. [Abstract] [Full Text]
|
|
|
|
|
|
L. L. Xu, B. G. Stackhouse, K. Florence, W. Zhang, N. Shanmugam, I. A. Sesterhenn, Z. Zou, V. Srikantan, M. Augustus, V. Roschke, et al. PSGR, a Novel Prostate-specific Gene with Homology to a G Protein-coupled Receptor, Is Overexpressed in Prostate Cancer Cancer Res., December 1, 2000; 60(23): 6568 - 6572. [Abstract] [Full Text]
|
|
|
|
|
|
J. McDonough, N. Francis, T. Miller, and E. S. Deneris Regulation of Transcription in the Neuronal Nicotinic Receptor Subunit Gene Cluster by a Neuron-selective Enhancer and ETS Domain Factors J. Biol. Chem., September 8, 2000; 275(37): 28962 - 28970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rudders, J. Gaspar, R. Madore, C. Voland, F. Grall, A. Patel, A. Pellacani, M. A. Perrella, T. A. Libermann, and P. Oettgen ESE-1 Is a Novel Transcriptional Mediator of Inflammation That Interacts with NF-kappa B to Regulate the Inducible Nitric-oxide Synthase Gene J. Biol. Chem., January 26, 2001; 276(5): 3302 - 3309. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
