HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Xiao, H. Articles by Isobe, K.-i. Search for Related Content PubMed PubMed Citation Articles by Xiao, H. Articles by Isobe, K.-i. Social Bookmarking                      What's this?

J Biol Chem, Vol. 275, Issue 2, 1371-1376, January 14, 2000

p300 Collaborates with Sp1 and Sp3 in p21^waf1/cip1 Promoter Activation Induced by Histone Deacetylase Inhibitor^*

Hengyi Xiao^§¶, Tadao Hasegawa, and Ken-ichi Isobe

From the  Department of Basic Gerontology, National Institute for Longevity Sciences, 36-3, Gengo Morioka-Cho, Obu, Aichi, 474-8522 Japan and the ^§ Institute of Cancer Research, West China University of Medical Sciences, Chengdu, Sichuan, 610041 People's Republic of China

We have reported that histone acetylation induced by trichostatin A (TSA) promotes p21^waf1/cip1 (p21) expression, the GC-box located just upstream of TATA box was responsible for TSA-induced promoter activation, and both Sp1 and Sp3 were the working activator of this GC-box. To understand the molecular pathway from histone acetylation to this Sp1 family factors-mediated promoter activation, we investigated the function of p300, one of the histone acetyltransferase, in the present work. The evidence supporting the linkage between p300 and TSA-induced p21 promoter activation were realized from the following findings: 1) cotransfection of p300 elevated p21 promoter activity, and this elevation was dependent on TSA-responsive GC-box; 2) TSA-induced promoter activation was blocked by the introduction of p300 dominant-negative mutant into cells; and 3) Sp1- or Sp3-mediated activation was also suppressed by this p300 dominant-negative mutant. Our data also suggested that p300 collaborates with Sp1 in a way which is different from that when p300 collaborates with p53 in p21 transcription.

---

^* This study was supported by the Fund for Comprehensive Research on Aging and Health and that for Longevity Sciences (101-03) from the Ministry of Health and Welfare of Japan.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

^¶ Present address: Laboratory for Genes of Motor Systems, Bio-mimetic Control Res., RIKEN.

To whom correspondence should be addressed. Tel.: 81-562-46-2311; Fax: 81-562-44-6591; E-mail: kenisobe@nils.go.jp.

---

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				V. Bartella, S. Cascio, E. Fiorio, A. Auriemma, A. Russo, and E. Surmacz Insulin-Dependent Leptin Expression in Breast Cancer Cells Cancer Res., June 15, 2008; 68(12): 4919 - 4927. [Abstract] [Full Text] [PDF]

				M. Yoshida, Y. Kabe, T. Wada, A. Asai, and H. Handa A New Mechanism of 6-((2-(Dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno(2,1-c)quinolin-7-one Dihydrochloride (TAS-103) Action Discovered by Target Screening with Drug-Immobilized Affinity Beads Mol. Pharmacol., March 1, 2008; 73(3): 987 - 994. [Abstract] [Full Text] [PDF]

				J.-Y. Chuang, Y.-T. Wang, S.-H. Yeh, Y.-W. Liu, W.-C. Chang, and J.-J. Hung Phosphorylation by c-Jun NH2-terminal Kinase 1 Regulates the Stability of Transcription Factor Sp1 during Mitosis Mol. Biol. Cell, March 1, 2008; 19(3): 1139 - 1151. [Abstract] [Full Text] [PDF]

				J. Fan, J. Stanfield, Y. Guo, J. A. Karam, E. Frenkel, X. Sun, and J.-T. Hsieh Effect of Trans-2,3-Dimethoxycinnamoyl Azide on Enhancing Antitumor Activity of Romidepsin on Human Bladder Cancer Clin. Cancer Res., February 15, 2008; 14(4): 1200 - 1207. [Abstract] [Full Text] [PDF]

				L. Andresen, H. Jensen, M. T. Pedersen, K. A. Hansen, and S. Skov Molecular Regulation of MHC Class I Chain-Related Protein A Expression after HDAC-Inhibitor Treatment of Jurkat T Cells J. Immunol., December 15, 2007; 179(12): 8235 - 8242. [Abstract] [Full Text] [PDF]

				Y.-J. Chen, Y.-N. Wang, and W.-C. Chang ERK2-mediated C-terminal Serine Phosphorylation of p300 Is Vital to the Regulation of Epidermal Growth Factor-induced Keratin 16 Gene Expression J. Biol. Chem., September 14, 2007; 282(37): 27215 - 27228. [Abstract] [Full Text] [PDF]

				M. De los Santos, A. Zambrano, and A. Aranda Combined effects of retinoic acid and histone deacetylase inhibitors on human neuroblastoma SH-SY5Y cells Mol. Cancer Ther., April 1, 2007; 6(4): 1425 - 1432. [Abstract] [Full Text] [PDF]

				F. Liu, N. Pore, M. Kim, K. R. Voong, M. Dowling, A. Maity, and G. D. Kao Regulation of Histone Deacetylase 4 Expression by the SP Family of Transcription Factors Mol. Biol. Cell, February 1, 2006; 17(2): 585 - 597. [Abstract] [Full Text] [PDF]

				I. Hoshino, H. Matsubara, N. Hanari, M. Mori, T. Nishimori, Y. Yoneyama, Y. Akutsu, H. Sakata, K. Matsushita, N. Seki, et al. Histone Deacetylase Inhibitor FK228 Activates Tumor Suppressor Prdx1 with Apoptosis Induction in Esophageal Cancer Cells Clin. Cancer Res., November 1, 2005; 11(21): 7945 - 7952. [Abstract] [Full Text] [PDF]

				J.-J. Hung, C.-Y. Wu, P.-C. Liao, and W.-C. Chang Hsp90{alpha} Recruited by Sp1 Is Important for Transcription of 12(S)-Lipoxygenase in A431 Cells J. Biol. Chem., October 28, 2005; 280(43): 36283 - 36292. [Abstract] [Full Text] [PDF]

				M. Sakaguchi, H. Sonegawa, T. Nukui, Y. Sakaguchi, M. Miyazaki, M. Namba, and N.-h. Huh Bifurcated converging pathways for high Ca2+- and TGF{beta}-induced inhibition of growth of normal human keratinocytes PNAS, September 27, 2005; 102(39): 13921 - 13926. [Abstract] [Full Text] [PDF]

				M. V. Blagosklonny, S. Trostel, G. Kayastha, Z. N. Demidenko, L. T. Vassilev, L. Y. Romanova, S. Bates, and T. Fojo Depletion of Mutant p53 and Cytotoxicity of Histone Deacetylase Inhibitors Cancer Res., August 15, 2005; 65(16): 7386 - 7392. [Abstract] [Full Text] [PDF]

				E. M. Ongeri, M. F. Verderame, and J. M. Hammond Follicle-Stimulating Hormone Induction of Ovarian Insulin-Like Growth Factor-Binding Protein-3 Transcription Requires a TATA Box-Binding Protein and the Protein Kinase A and Phosphatidylinositol-3 Kinase Pathways Mol. Endocrinol., July 1, 2005; 19(7): 1837 - 1848. [Abstract] [Full Text] [PDF]

				J.-P. Brouland, P. Gelebart, T. Kovacs, J. Enouf, J. Grossmann, and B. Papp The Loss of Sarco/Endoplasmic Reticulum Calcium Transport ATPase 3 Expression Is an Early Event during the Multistep Process of Colon Carcinogenesis Am. J. Pathol., July 1, 2005; 167(1): 233 - 242. [Abstract] [Full Text] [PDF]

				W. Huang, S. Zhao, S. Ammanamanchi, M. Brattain, K. Venkatasubbarao, and J. W. Freeman Trichostatin A Induces Transforming Growth Factor {beta} Type II Receptor Promoter Activity and Acetylation of Sp1 by Recruitment of PCAF/p300 to a Sp1{middle dot}NF-Y Complex J. Biol. Chem., March 18, 2005; 280(11): 10047 - 10054. [Abstract] [Full Text] [PDF]

				R. Varshochi, F. Halim, A. Sunters, J. P. Alao, P. A. Madureira, S. M. Hart, S. Ali, D. M. Vigushin, R. C. Coombes, and E. W.-F. Lam ICI182,780 Induces p21Waf1 Gene Transcription through Releasing Histone Deacetylase 1 and Estrogen Receptor {alpha} from Sp1 Sites to Induce Cell Cycle Arrest in MCF-7 Breast Cancer Cell Line J. Biol. Chem., February 4, 2005; 280(5): 3185 - 3196. [Abstract] [Full Text] [PDF]

				T. Torigoe, H. Izumi, T. Wakasugi, I. Niina, T. Igarashi, T. Yoshida, I. Shibuya, K. Chijiiwa, K.-i. Matsuo, H. Itoh, et al. DNA Topoisomerase II Poison TAS-103 Transactivates GC-Box-dependent Transcription via Acetylation of Sp1 J. Biol. Chem., January 14, 2005; 280(2): 1179 - 1185. [Abstract] [Full Text] [PDF]

				G. Tsika, J. Ji, and R. Tsika Sp3 Proteins Negatively Regulate {beta} Myosin Heavy Chain Gene Expression during Skeletal Muscle Inactivity Mol. Cell. Biol., December 15, 2004; 24(24): 10777 - 10791. [Abstract] [Full Text] [PDF]

				J. Hong, I. Samudio, S. Liu, M. Abdelrahim, and S. Safe Peroxisome Proliferator-Activated Receptor {gamma}-Dependent Activation of p21 in Panc-28 Pancreatic Cancer Cells Involves Sp1 and Sp4 Proteins Endocrinology, December 1, 2004; 145(12): 5774 - 5785. [Abstract] [Full Text] [PDF]

				T. J. O'Farrell, P. Ghosh, N. Dobashi, C. Y. Sasaki, and D. L. Longo Comparison of the Effect of Mutant and Wild-Type p53 on Global Gene Expression Cancer Res., November 15, 2004; 64(22): 8199 - 8207. [Abstract] [Full Text] [PDF]

				S. Ammanamanchi and M. G. Brattain Restoration of Transforming Growth Factor-{beta} Signaling through Receptor RI Induction by Histone Deacetylase Activity Inhibition in Breast Cancer Cells J. Biol. Chem., July 30, 2004; 279(31): 32620 - 32625. [Abstract] [Full Text] [PDF]

				N. Miki, M. Ikuta, and T. Matsui Hypoxia-induced Activation of the Retinoic Acid Receptor-related Orphan Receptor {alpha}4 Gene by an Interaction between Hypoxia-inducible Factor-1 and Sp1 J. Biol. Chem., April 9, 2004; 279(15): 15025 - 15031. [Abstract] [Full Text] [PDF]

				J.-F. Mouillet, C. Sonnenberg-Hirche, X. Yan, and Y. Sadovsky p300 Regulates the Synergy of Steroidogenic Factor-1 and Early Growth Response-1 in Activating Luteinizing Hormone-{beta} Subunit Gene J. Biol. Chem., February 27, 2004; 279(9): 7832 - 7839. [Abstract] [Full Text] [PDF]

				Y.-N. Wang and W.-C. Chang Induction of Disease-associated Keratin 16 Gene Expression by Epidermal Growth Factor Is Regulated through Cooperation of Transcription Factors Sp1 and c-Jun J. Biol. Chem., November 14, 2003; 278(46): 45848 - 45857. [Abstract] [Full Text] [PDF]

				M. Suzuki, N. Ueno, and A. Kuroiwa Hox Proteins Functionally Cooperate with the GC Box-binding Protein System through Distinct Domains J. Biol. Chem., August 8, 2003; 278(32): 30148 - 30156. [Abstract] [Full Text] [PDF]

				C. Zhang, M. M. Kavurma, A. Lai, and L. M. Khachigian Ets-1 Protects Vascular Smooth Muscle Cells from Undergoing Apoptosis by Activating p21WAF1/Cip1: ETS-1 REGULATES BASAL AND INDUCIBLE p21WAF1/Cip1 TRANSCRIPTION VIA DISTINCT CIS-ACTING ELEMENTS IN THE p21WAF1/Cip1 PROMOTER J. Biol. Chem., July 18, 2003; 278(30): 27903 - 27909. [Abstract] [Full Text] [PDF]

				J. L. Merchant, L. Bai, and M. Okada ZBP-89 Mediates Butyrate Regulation of Gene Expression J. Nutr., July 1, 2003; 133(7): 2456S - 2460. [Abstract] [Full Text] [PDF]

				J. R. Davie Inhibition of Histone Deacetylase Activity by Butyrate J. Nutr., July 1, 2003; 133(7): 2485S - 2493. [Abstract] [Full Text] [PDF]

				L. Zeng, Y. Zhang, S. Chien, X. Liu, and J. Y.-J. Shyy The Role of p53 Deacetylation in p21Waf1 Regulation by Laminar Flow J. Biol. Chem., June 27, 2003; 278(27): 24594 - 24599. [Abstract] [Full Text] [PDF]

				W.-G. Zhu, K. Srinivasan, Z. Dai, W. Duan, L. J. Druhan, H. Ding, L. Yee, M. A. Villalona-Calero, C. Plass, and G. A. Otterson Methylation of Adjacent CpG Sites Affects Sp1/Sp3 Binding and Activity in the p21Cip1 Promoter Mol. Cell. Biol., June 15, 2003; 23(12): 4056 - 4065. [Abstract] [Full Text] [PDF]

				A. Rascle, J. A. Johnston, and B. Amati Deacetylase Activity Is Required for Recruitment of the Basal Transcription Machinery and Transactivation by STAT5 Mol. Cell. Biol., June 15, 2003; 23(12): 4162 - 4173. [Abstract] [Full Text] [PDF]

				D. Hadaschik, K. Hinterkeuser, M. Oldak, H. J. Pfister, and S. Smola-Hess The Papillomavirus E2 Protein Binds to and Synergizes with C/EBP Factors Involved in Keratinocyte Differentiation J. Virol., May 1, 2003; 77(9): 5253 - 5265. [Abstract] [Full Text] [PDF]

				F. Nakatani, K. Tanaka, R. Sakimura, Y. Matsumoto, T. Matsunobu, X. Li, M. Hanada, T. Okada, and Y. Iwamoto Identification of p21WAF1/CIP1 as a Direct Target of EWS-Fli1 Oncogenic Fusion Protein J. Biol. Chem., April 18, 2003; 278(17): 15105 - 15115. [Abstract] [Full Text] [PDF]

				G. Lagger, A. Doetzlhofer, B. Schuettengruber, E. Haidweger, E. Simboeck, J. Tischler, S. Chiocca, G. Suske, H. Rotheneder, E. Wintersberger, et al. The Tumor Suppressor p53 and Histone Deacetylase 1 Are Antagonistic Regulators of the Cyclin-Dependent Kinase Inhibitor p21/WAF1/CIP1 Gene Mol. Cell. Biol., April 15, 2003; 23(8): 2669 - 2679. [Abstract] [Full Text] [PDF]

				T. Nowling, C. Bernadt, L. Johnson, M. Desler, and A. Rizzino The Co-activator p300 Associates Physically with and Can Mediate the Action of the Distal Enhancer of the FGF-4 Gene J. Biol. Chem., April 11, 2003; 278(16): 13696 - 13705. [Abstract] [Full Text] [PDF]

				S.-Y. Kim, M.-S. Woo, W.-K. Kim, E.-C. Choi, J. W. Henson, and H.-S. Kim Glial Cell-Specific Regulation of the JC Virus Early Promoter by Histone Deacetylase Inhibitors J. Virol., March 15, 2003; 77(6): 3394 - 3401. [Abstract] [Full Text] [PDF]

				N. Camarero, A. Nadal, M. J. Barrero, D. Haro, and P. F. Marrero Histone deacetylase inhibitors stimulate mitochondrial HMG-CoA synthase gene expression via a promoter proximal Sp1 site Nucleic Acids Res., March 15, 2003; 31(6): 1693 - 1703. [Abstract] [Full Text] [PDF]

				G. S. Kapoor, C. Golden, B. Atkins, and K. D. Mehta pp90RSK- and protein kinase C-dependent pathway regulates p42/44MAPK-induced LDL receptor transcription in HepG2 cells J. Lipid Res., March 1, 2003; 44(3): 584 - 593. [Abstract] [Full Text] [PDF]

				T. Fujii, J. C. Hogg, N. Keicho, R. Vincent, S. F. Van Eeden, and S. Hayashi Adenoviral E1A modulates inflammatory mediator expression by lung epithelial cells exposed to PM10 Am J Physiol Lung Cell Mol Physiol, February 1, 2003; 284(2): L290 - L297. [Abstract] [Full Text] [PDF]

				Y. Zhou, K. R. Mehta, A. P. Choi, S. Scolavino, and X. Zhang DNA Damage-induced Inhibition of Securin Expression Is Mediated by p53 J. Biol. Chem., January 3, 2003; 278(1): 462 - 470. [Abstract] [Full Text] [PDF]

				S.-I. Jang and P. M. Steinert Loricrin Expression in Cultured Human Keratinocytes Is Controlled by a Complex Interplay between Transcription Factors of the Sp1, CREB, AP1, and AP2 Families J. Biol. Chem., October 25, 2002; 277(44): 42268 - 42279. [Abstract] [Full Text] [PDF]

				D. Friedman, Z. Hu, E. A. Kolb, B. Gorfajn, and K. W. Scotto Ecteinascidin-743 Inhibits Activated but not Constitutive Transcription Cancer Res., June 1, 2002; 62(12): 3377 - 3381. [Abstract] [Full Text] [PDF]

				J. Tsubaki, V. Hwa, S. M. Twigg, and R. G. Rosenfeld Differential Activation of the IGF Binding Protein-3 Promoter by Butyrate in Prostate Cancer Cells Endocrinology, May 1, 2002; 143(5): 1778 - 1788. [Abstract] [Full Text] [PDF]

				A. R. Nawrocki, C. E. Goldring, R. M. Kostadinova, F. J. Frey, and B. M. Frey In Vivo Footprinting of the Human 11beta -Hydroxysteroid Dehydrogenase Type 2 Promoter. EVIDENCE FOR CELL-SPECIFIC REGULATION BY Sp1 AND Sp3 J. Biol. Chem., April 19, 2002; 277(17): 14647 - 14656. [Abstract] [Full Text] [PDF]

				J. Yoo, M.-J. Jeong, B.-M. Kwon, M.-W. Hur, Y.-M. Park, and M. Y. Han Activation of Dynamin I Gene Expression by Sp1 and Sp3 Is Required for Neuronal Differentiation of N1E-115 Cells J. Biol. Chem., March 29, 2002; 277(14): 11904 - 11909. [Abstract] [Full Text] [PDF]

				I. Lacroix, C. Lipcey, J. Imbert, and B. Kahn-Perles Sp1 Transcriptional Activity Is Up-regulated by Phosphatase 2A in Dividing T Lymphocytes J. Biol. Chem., March 8, 2002; 277(11): 9598 - 9605. [Abstract] [Full Text] [PDF]

				G. Steger, C. Schnabel, and H.-M. Schmidt The hinge region of the human papillomavirus type 8 E2 protein activates the human p21WAF1/CIP1 promoter via interaction with Sp1 J. Gen. Virol., March 1, 2002; 83(3): 503 - 510. [Abstract] [Full Text] [PDF]

				Q. Li, H. Xiao, and K.-i. Isobe Histone Acetyltransferase Activities of cAMP-Regulated Enhancer-Binding Protein and p300 in Tissues of Fetal, Young, and Old Mice J. Gerontol. A Biol. Sci. Med. Sci., March 1, 2002; 57(3): B93 - 98. [Abstract] [Full Text] [PDF]

				R. H. Kim, K. C. Flanders, S. B. Reffey, L. A. Anderson, C. S. Duckett, N. D. Perkins, and A. B. Roberts SNIP1 Inhibits NF-kappa B Signaling by Competing for Its Binding to the C/H1 Domain of CBP/p300 Transcriptional Co-activators J. Biol. Chem., November 30, 2001; 276(49): 46297 - 46304. [Abstract] [Full Text] [PDF]

				G. E. Walker, E. M. Wilson, D. Powell, and Y. Oh Butyrate, a Histone Deacetylase Inhibitor, Activates the Human IGF Binding Protein-3 Promoter in Breast Cancer Cells: Molecular Mechanism Involves an Sp1/Sp3 Multiprotein Complex Endocrinology, September 1, 2001; 142(9): 3817 - 3827. [Abstract] [Full Text] [PDF]

				T. Ragoczy and G. Miller Autostimulation of the Epstein-Barr Virus BRLF1 Promoter Is Mediated through Consensus Sp1 and Sp3 Binding Sites J. Virol., June 1, 2001; 75(11): 5240 - 5251. [Abstract] [Full Text]

				L. Bai and J. L. Merchant Transcription Factor ZBP-89 Cooperates with Histone Acetyltransferase p300 during Butyrate Activation of p21waf1 Transcription in Human Cells J. Biol. Chem., September 22, 2000; 275(39): 30725 - 30733. [Abstract] [Full Text] [PDF]

				F. Liang, F. Schaufele, and D. G. Gardner Functional Interaction of NF-Y and Sp1 Is Required for Type A Natriuretic Peptide Receptor Gene Transcription J. Biol. Chem., January 5, 2001; 276(2): 1516 - 1522. [Abstract] [Full Text] [PDF]

				B. Han, N. Liu, X. Yang, H. B. Sun, and Y.-C. Yang MRG1 Expression in Fibroblasts Is Regulated by Sp1/Sp3 and an Ets Transcription Factor J. Biol. Chem., March 9, 2001; 276(11): 7937 - 7942. [Abstract] [Full Text] [PDF]

				J. Song, H. Ugai, I. Kanazawa, K. Sun, and K. K. Yokoyama Independent Repression of a GC-rich Housekeeping Gene by Sp1 and MAZ Involves the Same cis-Elements J. Biol. Chem., June 1, 2001; 276(23): 19897 - 19904. [Abstract] [Full Text] [PDF]

M. Nicolas, V. Noe, K. B. Jensen, and C. J. Ciudad Cloning and Characterization of the 5'-Flanking Region of the Human Transcription Factor Sp1 Gene J. Biol. Chem.,