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J Biol Chem, Vol. 275, Issue 2, 721-724, January 14, 2000
From the Connective Tissue Biology Laboratories, Cardiff School of
Biosciences, Cardiff University, Museum Avenue, Cardiff CF10
3US, United Kingdom
This study describes specific molecular
mechanisms by which supplementation with n-3 fatty acids
(i.e. those present in fish oils) can modulate the
expression and activity of degradative and inflammatory factors that
cause cartilage destruction during arthritis. Our data show that
incorporation of n-3 fatty acids (but not other
polyunsaturated or saturated fatty acids) into articular cartilage
chondrocyte membranes results in a dose-dependent reduction
in: (i) the expression and activity of proteoglycan degrading enzymes
(aggrecanases) and (ii) the expression of inflammation-inducible cytokines (interleukin (IL)-1 The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF192770 and AF192771.
ACCELERATED PUBLICATION
n-3 Fatty Acids Specifically Modulate Catabolic
Factors Involved in Articular Cartilage Degradation*
,
and tumor necrosis factor (TNF)-) and cyclooxygenase (COX-2), but not the constitutively expressed cyclooxygenase COX-1. These findings provide evidence that
n-3 fatty acid supplementation can specifically affect
regulatory mechanisms involved in chondrocyte gene transcription and
thus further advocate a beneficial role for dietary fish oil
supplementation in alleviation of several of the physiological
parameters that cause and propogate arthritic disease.
*
This work was funded by the Arthritis Research Campaign,
United Kingdom.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Arthritis Research Campaign Postdoctoral Research Fellow.
§
Arthritis Research Campaign Postdoctoral Research Fellow.
¶
To whom correspondence should be addressed: Connective Tissue
Biology Laboratories, Cardiff School of Biosciences, Cardiff University, Museum Ave., Biomedical Sciences Bldg., Cardiff CF10 3US,
Wales, UK. E-mail: caterson@Cardiff.ac.uk.
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