|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 20, 14838-14845, May 19, 2000
From the We investigated whether microtubule-interfering
agents (MIAs: taxol, colchicine, nocodazole, vinblastine, vincristine,
17-
Microtubule-interfering Agents Stimulate the Transcription of
Cyclooxygenase-2
EVIDENCE FOR INVOLVEMENT OF ERK1/2 AND p38 MITOGEN-ACTIVATED
PROTEIN KINASE PATHWAYS*
§,,
Department of Medicine, New York
Presbyterian Hospital-Cornell and Strang Cancer Prevention Center and
¶ Breast Cancer Medicine Service, Memorial Sloan-Kettering Cancer
Center, New York, New York 10021
-estradiol, 2-methoxyestradiol) altered cyclooxygenase-2 (COX-2)
expression in human mammary epithelial cells. MIAs enhanced
prostaglandin E2 synthesis and increased levels of
COX-2 protein and mRNA. Nuclear run-off assays revealed increased
rates of COX-2 transcription after treatment with MIAs.
Calphostin C, an inhibitor of protein kinase C, blocked the induction
of COX-2 by MIAs. The stimulation of COX-2 promoter
activity by MIAs was inhibited by overexpressing dominant negative
forms of Rho and Raf-1. MIAs stimulated ERK, JNK, and p38
mitogen-activated protein kinases (MAPK); pharmacological inhibitors of
MAPK kinase and p38 MAPK blocked the induction of COX-2 by MIAs.
Overexpressing dominant negative forms of ERK1 or p38 MAPK inhibited
MIA-mediated activation of the COX-2 promoter. MIAs
stimulated the binding of the activator protein-1 transcription factor
complex to the cyclic AMP response element in the COX-2 promoter. A dominant negative form of c-Jun inhibited the activation of
the COX-2 promoter by MIAs. Additionally, cytochalasin D,
an agent that inhibits actin polymerization, stimulated
COX-2 transcription by the same signaling pathway as MIAs.
Thus, microtubule- or actin-interfering agents stimulated MAPK
signaling and activator protein-1 activity. This led, in turn, to
induction of COX-2 gene expression via the cyclic AMP
response element site in the COX-2 promoter.
*
This work was supported in part by S/G 2P01 CA68425 and the
James E. Olson Memorial Fund.The costs of publication of this article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D. Zhang, L. Qiu, X. Jin, Z. Guo, and C. Guo Nuclear Factor-{kappa}B Inhibition by Parthenolide Potentiates the Efficacy of Taxol in Non-Small Cell Lung Cancer In vitro and In vivo Mol. Cancer Res., July 1, 2009; 7(7): 1139 - 1149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. R. Healy, F. Zhu, J. D. Stull, and K. Konstantopoulos Elucidation of the signaling network of COX-2 induction in sheared chondrocytes: COX-2 is induced via a Rac/MEKK1/MKK7/JNK2/c-Jun-C/EBP{beta}-dependent pathway Am J Physiol Cell Physiol, May 1, 2008; 294(5): C1146 - C1157. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Arany, B. K. Wagner, Y. Ma, J. Chinsomboon, D. Laznik, and B. M. Spiegelman Gene expression-based screening identifies microtubule inhibitors as inducers of PGC-1{alpha} and oxidative phosphorylation PNAS, March 25, 2008; 105(12): 4721 - 4726. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hohla, A. V. Schally, C. A. Kanashiro, S. Buchholz, B. Baker, C. Kannadka, A. Moder, E. Aigner, C. Datz, and G. Halmos Growth inhibition of non-small-cell lung carcinoma by BN/GRP antagonist is linked with suppression of K-Ras, COX-2, and pAkt PNAS, November 20, 2007; 104(47): 18671 - 18676. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. M. Mhaidat, R. F. Thorne, X. D. Zhang, and P. Hersey Regulation of Docetaxel-Induced Apoptosis of Human Melanoma Cells by Different Isoforms of Protein Kinase C Mol. Cancer Res., October 1, 2007; 5(10): 1073 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. C. Azim, H. Cao, X. Gao, M. Joo, A. B. Malik, R. B. van Breemen, R. T. Sadikot, G. Park, and J. W. Christman Regulation of cyclooxygenase-2 expression by small GTPase Rac2 in bone marrow macrophages Am J Physiol Lung Cell Mol Physiol, September 1, 2007; 293(3): L668 - L673. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Islam, C. J. Amuzie, J. R. Harkema, and J. J. Pestka Neurotoxicity and Inflammation in the Nasal Airways of Mice Exposed to the Macrocyclic Trichothecene Mycotoxin Roridin A: Kinetics and Potentiation by Bacterial Lipopolysaccharide Coexposure Toxicol. Sci., August 1, 2007; 98(2): 526 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Xu and H.-K. G. Shu EGFR Activation Results in Enhanced Cyclooxygenase-2 Expression through p38 Mitogen-Activated Protein Kinase-Dependent Activation of the Sp1/Sp3 Transcription Factors in Human Gliomas Cancer Res., July 1, 2007; 67(13): 6121 - 6129. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yano, T. Matsumura, T. Senokuchi, N. Ishii, Y. Murata, K. Taketa, H. Motoshima, T. Taguchi, K. Sonoda, D. Kukidome, et al. Statins Activate Peroxisome Proliferator-Activated Receptor {gamma} Through Extracellular Signal-Regulated Kinase 1/2 and p38 Mitogen-Activated Protein Kinase-Dependent Cyclooxygenase-2 Expression in Macrophages Circ. Res., May 25, 2007; 100(10): 1442 - 1451. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. M. Mhaidat, X. D. Zhang, C. C. Jiang, and P. Hersey Docetaxel-Induced Apoptosis of Human Melanoma Is Mediated by Activation of c-Jun NH2-Terminal Kinase and Inhibited by the Mitogen-Activated Protein Kinase Extracellular Signal-Regulated Kinase 1/2 Pathway Clin. Cancer Res., February 15, 2007; 13(4): 1308 - 1314. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Zou, M. Adachi, K. Imai, M. Hareyama, K. Yoshioka, S. Zhao, and Y. Shinomura 2-Methoxyestradiol, an Endogenous Mammalian Metabolite, Radiosensitizes Colon Carcinoma Cells through c-Jun NH2-Terminal Kinase Activation. Clin. Cancer Res., November 1, 2006; 12(21): 6532 - 6539. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Csiki and D. H. Johnson Did Targeted Therapy Fail Cyclooxygenase Too? J. Clin. Oncol., October 20, 2006; 24(30): 4798 - 4800. [Full Text] [PDF]
|
|
|
|
 |
|
 M. Hirao, N. Tamai, N. Tsumaki, H. Yoshikawa, and A. Myoui Oxygen Tension Regulates Chondrocyte Differentiation and Function during Endochondral Ossification J. Biol. Chem., October 13, 2006; 281(41): 31079 - 31092. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Hohla, A. V. Schally, K. Szepeshazi, J. L. Varga, S. Buchholz, F. Koster, E. Heinrich, G. Halmos, F. G. Rick, C. Kannadka, et al. Synergistic inhibition of growth of lung carcinomas by antagonists of growth hormone-releasing hormone in combination with docetaxel PNAS, September 26, 2006; 103(39): 14513 - 14518. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. P. V. Dantas and K. Sandberg Does 2-Methoxyestradiol Represent the New and Improved Hormone Replacement Therapy for Atherosclerosis? Circ. Res., August 4, 2006; 99(3): 234 - 237. [Full Text] [PDF]
|
|
|
|
|
|
F. Barchiesi, E. K. Jackson, J. Fingerle, D. G. Gillespie, B. Odermatt, and R. K. Dubey 2-Methoxyestradiol, an Estradiol Metabolite, Inhibits Neointima Formation and Smooth Muscle Cell Growth via Double Blockade of the Cell Cycle Circ. Res., August 4, 2006; 99(3): 266 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-Y. Tang, A. Shih, H. J. Cao, F. B. Davis, P. J. Davis, and H.-Y. Lin Resveratrol-induced cyclooxygenase-2 facilitates p53-dependent apoptosis in human breast cancer cells. Mol. Cancer Ther., August 1, 2006; 5(8): 2034 - 2042. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Croft and S. A. Przyborski Formation of neurons by non-neural adult stem cells: potential mechanism implicates an artifact of growth in culture. Stem Cells, August 1, 2006; 24(8): 1841 - 1851. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Wang, C.-Y. Ko, L.-C. Chen, W.-L. Wang, and W.-C. Chang Functional role of NF-IL6{beta} and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene Nucleic Acids Res., January 5, 2006; 34(1): 217 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. V. Grishin, J. Wang, D. A. Potoka, D. J. Hackam, J. S. Upperman, P. Boyle, R. Zamora, and H. R. Ford Lipopolysaccharide Induces Cyclooxygenase-2 in Intestinal Epithelium via a Noncanonical p38 MAPK Pathway J. Immunol., January 1, 2006; 176(1): 580 - 588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Csiki, J. D. Morrow, A. Sandler, Y. Shyr, J. Oates, M. K. Williams, T. Dang, D. P. Carbone, and D. H. Johnson Targeting Cyclooxygenase-2 in Recurrent Non-Small Cell Lung Cancer: A Phase II Trial of Celecoxib and Docetaxel Clin. Cancer Res., September 15, 2005; 11(18): 6634 - 6640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Li, Y. Mao, P. W. Brandt-Rauf, A. C. Williams, and R. L. Fine Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathway Mol. Cancer Ther., June 1, 2005; 4(6): 901 - 909. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. K. Altorki, J. L. Port, F. Zhang, D. Golijanin, H. T. Thaler, A. J. Duffield-Lillico, K. Subbaramaiah, and A. J. Dannenberg Chemotherapy Induces the Expression of Cyclooxygenase-2 in Non-Small Cell Lung Cancer Clin. Cancer Res., June 1, 2005; 11(11): 4191 - 4197. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Daikoku, D. Wang, S. Tranguch, J. D. Morrow, S. Orsulic, R. N. DuBois, and S. K. Dey Cyclooxygenase-1 Is a Potential Target for Prevention and Treatment of Ovarian Epithelial Cancer Cancer Res., May 1, 2005; 65(9): 3735 - 3744. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. J. Kim, I. A. Murray, A. M. Burns, F. J. Gonzalez, G. H. Perdew, and J. M. Peters Peroxisome Proliferator-activated Receptor-{beta}/{delta} Inhibits Epidermal Cell Proliferation by Down-regulation of Kinase Activity J. Biol. Chem., March 11, 2005; 280(10): 9519 - 9527. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. L. Gauthier, C. R. Pickering, C. J. Miller, C. A. Fordyce, K. L. Chew, H. K. Berman, and T. D. Tlsty p38 Regulates Cyclooxygenase-2 in Human Mammary Epithelial Cells and Is Activated in Premalignant Tissue Cancer Res., March 1, 2005; 65(5): 1792 - 1799. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. W. Yim, H.-S. Jong, T. Y. Kim, H. H. Choi, S. G. Kim, S. H. Song, J. Kim, S.-G. Ko, J. W. Lee, T.-Y. Kim, et al. Cyclooxygenase-2 Inhibits Novel Ginseng Metabolite-Mediated Apoptosis Cancer Res., March 1, 2005; 65(5): 1952 - 1960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. V. Bava, V. T. Puliappadamba, A. Deepti, A. Nair, D. Karunagaran, and R. J. Anto Sensitization of Taxol-induced Apoptosis by Curcumin Involves Down-regulation of Nuclear Factor-{kappa}B and the Serine/Threonine Kinase Akt and Is Independent of Tubulin Polymerization J. Biol. Chem., February 25, 2005; 280(8): 6301 - 6308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Qian, K. J. Liu, Y. Chen, D. C. Flynn, V. Castranova, and X. Shi Cdc42 Regulates Arsenic-induced NADPH Oxidase Activation and Cell Migration through Actin Filament Reorganization J. Biol. Chem., February 4, 2005; 280(5): 3875 - 3884. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-H. Kim, Y.-H. Kim, K.-J. Shin, Y.-S. Oh, C. S. Lee, K.-O. Kang, S. H. Ryu, and P.-G. Suh 2,2',4,6,6'-Pentachlorobiphenyl-Induced Apoptosis Is Limited by Cyclooxygenase-2 Induction Toxicol. Sci., February 1, 2005; 83(2): 397 - 404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.-C. Wang, W.-N. Lin, C.-W. Lee, C.-C. Lin, S.-F. Luo, J.-S. Wang, and C.-M. Yang Involvement of p42/p44 MAPK, p38 MAPK, JNK, and NF-{kappa}B in IL-1{beta}-induced VCAM-1 expression in human tracheal smooth muscle cells Am J Physiol Lung Cell Mol Physiol, February 1, 2005; 288(2): L227 - L237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Zaric and C. Ruegg Integrin-mediated Adhesion and Soluble Ligand Binding Stabilize COX-2 Protein Levels in Endothelial Cells by Inducing Expression and Preventing Degradation J. Biol. Chem., January 14, 2005; 280(2): 1077 - 1085. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Dannenberg, S. M. Lippman, J. R. Mann, K. Subbaramaiah, and R. N. DuBois Cyclooxygenase-2 and Epidermal Growth Factor Receptor: Pharmacologic Targets for Chemoprevention J. Clin. Oncol., January 10, 2005; 23(2): 254 - 266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun and F. A. Sinicrope Selective inhibitors of MEK1/ERK44/42 and p38 mitogen-activated protein kinases potentiate apoptosis induction by sulindac sulfide in human colon carcinoma cells Mol. Cancer Ther., January 1, 2005; 4(1): 51 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Hinz, R. Ramer, K. Eichele, U. Weinzierl, and K. Brune Up-Regulation of Cyclooxygenase-2 Expression Is Involved in R(+)-Methanandamide-Induced Apoptotic Death of Human Neuroglioma Cells Mol. Pharmacol., December 1, 2004; 66(6): 1643 - 1651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. A. Rossen, J. Bouma, R. H. C. Raatgeep, H. A. Buller, and A. W. C. Einerhand Inhibition of Cyclooxygenase Activity Reduces Rotavirus Infection at a Postbinding Step J. Virol., September 15, 2004; 78(18): 9721 - 9730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Galindo, A. A. Fadl, J. Sha, C. Gutierrez Jr., V. L. Popov, I. Boldogh, B. B. Aggarwal, and A. K. Chopra Aeromonas hydrophila Cytotoxic Enterotoxin Activates Mitogen-activated Protein Kinases and Induces Apoptosis in Murine Macrophages and Human Intestinal Epithelial Cells J. Biol. Chem., September 3, 2004; 279(36): 37597 - 37612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Sirois, K. Sayasith, K. A. Brown, A. E. Stock, N. Bouchard, and M. Dore Cyclooxygenase-2 and its role in ovulation: a 2004 account Hum. Reprod. Update, September 1, 2004; 10(5): 373 - 385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Biarc, I. S. Nguyen, A. Pini, F. Gosse, S. Richert, D. Thierse, A. Van Dorsselaer, E. Leize-Wagner, F. Raul, J.-P. Klein, et al. Carcinogenic properties of proteins with pro-inflammatory activity from Streptococcus infantarius (formerly S.bovis) Carcinogenesis, August 1, 2004; 25(8): 1477 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Brown and R. N. DuBois Cyclooxygenase-2 in Lung Carcinogenesis and Chemoprevention: Roger S. Mitchell Lecture Chest, May 1, 2004; 125(5_suppl): 134S - 140S. [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Norvell, S. M. Ponik, D. K. Bowen, R. Gerard, and F. M. Pavalko Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules J Appl Physiol, March 1, 2004; 96(3): 957 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Faisal, S. Kleiner, and Y. Nagamine Non-redundant Role of Shc in Erk Activation by Cytoskeletal Reorganization J. Biol. Chem., January 30, 2004; 279(5): 3202 - 3211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. S. Zoubiane, A. Valentijn, E. T. Lowe, N. Akhtar, S. Bagley, A. P. Gilmore, and C. H. Streuli A role for the cytoskeleton in prolactin-dependent mammary epithelial cell differentiation J. Cell Sci., January 15, 2004; 117(2): 271 - 280. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. G. Tessner, F. Muhale, S. Schloemann, S. M. Cohn, A. R. Morrison, and W. F. Stenson Ionizing radiation up-regulates cyclooxygenase-2 in I407 cells through p38 mitogen-activated protein kinase Carcinogenesis, January 1, 2004; 25(1): 37 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Ott, D. Iwanciw, A. Graness, K. Giehl, and M. Goppelt-Struebe Modulation of the Expression of Connective Tissue Growth Factor by Alterations of the Cytoskeleton J. Biol. Chem., November 7, 2003; 278(45): 44305 - 44311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S.-J. Kim, S.-G. Hwang, I.-C. Kim, and J.-S. Chun Actin Cytoskeletal Architecture Regulates Nitric Oxide-induced Apoptosis, Dedifferentiation, and Cyclooxygenase-2 Expression in Articular Chondrocytes via Mitogen-activated Protein Kinase and Protein Kinase C Pathways J. Biol. Chem., October 24, 2003; 278(43): 42448 - 42456. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. S. De Lorenzo, K. Yamaguchi, K. Subbaramaiah, and A. J. Dannenberg Bryostatin-1 Stimulates the Transcription of Cyclooxygenase-2: Evidence for an Activator Protein-1-Dependent Mechanism Clin. Cancer Res., October 15, 2003; 9(13): 5036 - 5043. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Castelao, R. D. Bart III, C. A. DiPerna, E. M. Sievers, and R. M. Bremner Lung cancer and cyclooxygenase-2 Ann. Thorac. Surg., October 1, 2003; 76(4): 1327 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Subbaramaiah, T. P. Marmo, D. A. Dixon, and A. J. Dannenberg Regulation of Cyclooxgenase-2 mRNA Stability by Taxanes: EVIDENCE FOR INVOLVEMENT OF p38, MAPKAPK-2, and HuR J. Biol. Chem., September 26, 2003; 278(39): 37637 - 37647. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Dmitrovsky Combining Cytotoxic Chemotherapy With Cyclooxygenase-2 Inhibition J. Clin. Oncol., July 15, 2003; 21(14): 2631 - 2632. [Full Text] [PDF]
|
|
|
|
|
|
N.K. Altorki, R.S. Keresztes, J.L. Port, D.M. Libby, R.J. Korst, D.B. Flieder, C.A. Ferrara, D.F. Yankelevitz, K. Subbaramaiah, M.W. Pasmantier, et al. Celecoxib, a Selective Cyclo-Oxygenase-2 Inhibitor, Enhances the Response to Preoperative Paclitaxel and Carboplatin in Early-Stage Non-Small-Cell Lung Cancer J. Clin. Oncol., July 15, 2003; 21(14): 2645 - 2650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Reshkin, A. Bellizzi, R. A. Cardone, M. Tommasino, V. Casavola, and A. Paradiso Paclitaxel Induces Apoptosis via Protein Kinase A- and p38 Mitogen-activated Protein-dependent Inhibition of the Na+/H+ Exchanger (NHE) NHE Isoform 1 in Human Breast Cancer Cells Clin. Cancer Res., June 1, 2003; 9(6): 2366 - 2373. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shimada, M. Nakamura, E. Ishida, M. Kishi, and N. Konishi Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis Carcinogenesis, June 1, 2003; 24(6): 1067 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. N. DuBois Evaluation of the Whole Prostaglandin Biosynthetic Pathway in Lung Cancer Clin. Cancer Res., May 1, 2003; 9(5): 1577 - 1578. [Full Text] [PDF]
|
|
|
|
 |
|
 K. Deacon, P. Mistry, J. Chernoff, J. L. Blank, and R. Patel p38 Mitogen-Activated Protein Kinase Mediates Cell Death and p21-Activated Kinase Mediates Cell Survival during Chemotherapeutic Drug-induced Mitotic Arrest Mol. Biol. Cell, May 1, 2003; 14(5): 2071 - 2087. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Chauhan, G. Li, D. Auclair, T. Hideshima, P. Richardson, K. Podar, N. Mitsiades, C. Mitsiades, C. Li, R. S. Kim, et al. Identification of genes regulated by 2-methoxyestradiol (2ME2) in multiple myeloma cells using oligonucleotide arrays Blood, May 1, 2003; 101(9): 3606 - 3614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Giuliano High-Content Profiling of Drug-Drug Interactions: Cellular Targets Involved in the Modulation of Microtubule Drug Action by the Antifungal Ketoconazole J Biomol Screen, April 1, 2003; 8(2): 125 - 135. [Abstract] [PDF]
|
|
|
|
 |
|
 S. A. Milne and H. N. Jabbour Prostaglandin (PG) F2{alpha} Receptor Expression and Signaling in Human Endometrium: Role of PGF2{alpha} in Epithelial Cell Proliferation J. Clin. Endocrinol. Metab., April 1, 2003; 88(4): 1825 - 1832. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Gupta, L. V. Tejada, B. J. Tong, S. K. Das, J. D. Morrow, S. K. Dey, and R. N. DuBois Cyclooxygenase-1 is Overexpressed and Promotes Angiogenic Growth Factor Production in Ovarian Cancer Cancer Res., March 1, 2003; 63(5): 906 - 911. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y.-J. Jung, J. S. Isaacs, S. Lee, J. Trepel, and L. Neckers Microtubule Disruption Utilizes an NFkappa B-dependent Pathway to Stabilize HIF-1alpha Protein J. Biol. Chem., February 21, 2003; 278(9): 7445 - 7452. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. G. Tessner, F. Muhale, S. Schloemann, S. M. Cohn, A. Morrison, and W. F. Stenson Basic fibroblast growth factor upregulates cyclooxygenase-2 in I407 cells through p38 MAP kinase Am J Physiol Gastrointest Liver Physiol, February 1, 2003; 284(2): G269 - G279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. H. Yoo, M. P. Piechocki, J. F. Ensley, T. Nguyen, J. Oliver, H. Meng, D. Kewson, T. Y. Shibuya, F. Lonardo, and M. A. Tainsky Docetaxel Induced Gene Expression Patterns in Head and Neck Squamous Cell Carcinoma Using cDNA Microarray and PowerBlot Clin. Cancer Res., December 1, 2002; 8(12): 3910 - 3921. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Monick, P. K. Robeff, N. S. Butler, D. M. Flaherty, A. B. Carter, M. W. Peterson, and G. W. Hunninghake Phosphatidylinositol 3-Kinase Activity Negatively Regulates Stability of Cyclooxygenase 2 mRNA J. Biol. Chem., August 30, 2002; 277(36): 32992 - 33000. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Han, S. Tsui, and T. J. Smith Up-regulation of Prostaglandin E2 Synthesis by Interleukin-1beta in Human Orbital Fibroblasts Involves Coordinate Induction of Prostaglandin-Endoperoxide H Synthase-2 and Glutathione-dependent Prostaglandin E2 Synthase Expression J. Biol. Chem., May 3, 2002; 277(19): 16355 - 16364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Cassidy, P. J. Moos, R. C. Kelly, and F. A. Fitzpatrick Cyclooxygenase-2 Induction by Paclitaxel, Docetaxel, and Taxane Analogues in Human Monocytes and Murine Macrophages: Structure-Activity Relationships and Their Implications Clin. Cancer Res., March 1, 2002; 8(3): 846 - 855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Samarakoon and P. J. Higgins MEK/ERK pathway mediates cell-shape-dependent plasminogen activator inhibitor type 1 gene expression upon drug-induced disruption of the microfilament and microtubule networks J. Cell Sci., January 8, 2002; 115(15): 3093 - 3103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Sawyer, S. M. Norvell, S. M. Ponik, and F. M. Pavalko Regulation of PGE2 and PGI2 release from human umbilical vein endothelial cells by actin cytoskeleton Am J Physiol Cell Physiol, September 1, 2001; 281(3): C1038 - C1045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. HALLSWORTH, L. M. MOIR, D. LAI, and S. J. HIRST Inhibitors of Mitogen-activated Protein Kinases Differentially Regulate Eosinophil-activating Cytokine Release from Human Airway Smooth Muscle Am. J. Respir. Crit. Care Med., August 15, 2001; 164(4): 688 - 697. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Jorquera and R. M. Tanguay Fumarylacetoacetate, the metabolite accumulating in hereditary tyrosinemia, activates the ERK pathway and induces mitotic abnormalities and genomic instability Hum. Mol. Genet., August 1, 2001; 10(17): 1741 - 1752. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hyun Song, H.-S. Jong, H. H. Choi, H. Inoue, T. Tanabe, N. K. Kim, and Y.-J. Bang Transcriptional Silencing of Cyclooxygenase-2 by Hyper-methylation of the 5' CpG Island in Human Gastric Carcinoma Cells Cancer Res., June 1, 2001; 61(11): 4628 - 4635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Bourgarel-Rey, S. Vallee, O. Rimet, S. Champion, D. Braguer, A. Desobry, C. Briand, and Y. Barra Involvement of Nuclear Factor kappa B in c-Myc Induction by Tubulin Polymerization Inhibitors Mol. Pharmacol., April 16, 2001; 59(5): 1165 - 1170. [Abstract] [Full Text]
|
|
|
|
|
|
V. Subbarayan, A. L. Sabichi, N. Llansa, S. M. Lippman, and D. G. Menter Differential Expression of Cyclooxygenase-2 and Its Regulation by Tumor Necrosis Factor-{{alpha}} in Normal and Malignant Prostate Cells Cancer Res., March 1, 2001; 61(6): 2720 - 2726. [Abstract] [Full Text]
|
|
|
|
|
|
S. Kulkarni, J. S. Rader, F. Zhang, H. Liapis, A. T. Koki, J. L. Masferrer, K. Subbaramaiah, and A. J. Dannenberg Cyclooxygenase-2 Is Overexpressed in Human Cervical Cancer Clin. Cancer Res., February 1, 2001; 7(2): 429 - 434. [Abstract] [Full Text]
|
|
|
|
|
|
K. Subbaramaiah, D. T. Lin, J. C. Hart, and A. J. Dannenberg Peroxisome Proliferator-activated Receptor gamma Ligands Suppress the Transcriptional Activation of Cyclooxygenase-2. EVIDENCE FOR INVOLVEMENT OF ACTIVATOR PROTEIN-1 AND CREB-BINDING PROTEIN/p300 J. Biol. Chem., April 6, 2001; 276(15): 12440 - 12448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-i. Okano and A. K. Rustgi Paclitaxel Induces Prolonged Activation of the Ras/MEK/ERK Pathway Independently of Activating the Programmed Cell Death Machinery J. Biol. Chem., May 25, 2001; 276(22): 19555 - 19564. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. de Gregorio, M. A. Iniguez, M. Fresno, and S. Alemany Cot Kinase Induces Cyclooxygenase-2 Expression in T Cells through Activation of the Nuclear Factor of Activated T Cells J. Biol. Chem., July 13, 2001; 276(29): 27003 - 27009. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Guzman-Verri, E. Chaves-Olarte, C. von Eichel-Streiber, I. Lopez-Goni, M. Thelestam, S. Arvidson, J.-P. Gorvel, and E. Moreno GTPases of the Rho Subfamily Are Required for Brucella abortus Internalization in Nonprofessional Phagocytes. DIRECT ACTIVATION OF Cdc42 J. Biol. Chem., November 21, 2001; 276(48): 44435 - 44443. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |