| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 20, 15166-15173, May 19, 2000
From the Departments of While molecular mechanisms for iron entry and
storage within cells have been elucidated, no system to mediate iron
efflux has been heretofore identified. We now describe an ATP requiring iron transporter in mammalian cells. 55Fe is
transported into microsomal vesicles in a Mg-ATP-dependent fashion. The transporter is specific for ferrous iron, is temperature- and time-dependent, and detected only with hydrolyzable
nucleotides. It differs from all known ATPases and appears to be a
P-type ATPase. The Fe-ATPase is localized together with heme
oxygenase-1 to microsomal membranes with both proteins greatly enriched
in the spleen. Iron treatment markedly induces
ATP-dependent iron transport in RAW 264.7 macrophage cells
with an initial phase that is resistant to cycloheximide and
actinomycin D and a later phase that is inhibited by these agents. Iron
release, elicited in intact rats by glycerol-induced rhabdomyolysis,
induces ATP-dependent iron transport in the kidney. Mice
with genomic deletion of heme oxygenase-1 have selective tissue iron
accumulation and display augmented ATP-dependent iron transport in those tissues that accumulate iron.
A Mammalian Iron ATPase Induced by Iron*
,§,,,¶
, and**
Neuroscience,
¶ Pharmacology and Molecular Sciences, and Psychiatry and
Behavioral Sciences, and ** Department of Medicine, Division of
Gastroenterology, The Johns Hopkins University School of Medicine,
Baltimore, Maryland 21205
*
This work was supported by United States Public Health
Service Grant MH-18501 and Research Scientist Awards DA-00074 (to
S. H. S.) and DA-05900 (to D. E. B.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Howard Hughes Fellowship for Physicians. To whom correspondence
should be addressed. Tel.: 410-955-2380; Fax: 410-955-3623; E-mail:
cferris@jhmi.edu.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  J. l. Sullivan Macrophage Iron, Hepcidin, and Atherosclerotic Plaque Stability Experimental Biology and Medicine, September 1, 2007; 232(8): 1014 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. E. Milbury, B. Graf, J. M. Curran-Celentano, and J. B. Blumberg Bilberry (Vaccinium myrtillus) Anthocyanins Modulate Heme Oxygenase-1 and Glutathione S-Transferase-pi Expression in ARPE-19 Cells Invest. Ophthalmol. Vis. Sci., May 1, 2007; 48(5): 2343 - 2349. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, D. Morse, and A. M. K. Choi Carbon Monoxide and Bilirubin: Potential Therapies for Pulmonary/Vascular Injury and Disease Am. J. Respir. Cell Mol. Biol., February 1, 2007; 36(2): 175 - 182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Tracz, J. Alam, and K. A. Nath Physiology and Pathophysiology of Heme: Implications for Kidney Disease J. Am. Soc. Nephrol., February 1, 2007; 18(2): 414 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jantaro, Q. Ali, S. Lone, and Q. He Suppression of the Lethality of High Light to a Quadruple HLI Mutant by the Inactivation of the Regulatory Protein PfsR in Synechocystis PCC 6803 J. Biol. Chem., October 13, 2006; 281(41): 30865 - 30874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Juncos, J. P. Grande, N. Murali, A. J. Croatt, L. A. Juncos, R. P. Hebbel, Z. S. Katusic, and K. A. Nath Anomalous Renal Effects of Tin Protoporphyrin in a Murine Model of Sickle Cell Disease Am. J. Pathol., July 1, 2006; 169(1): 21 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. Ryter, J. Alam, and A. M. K. Choi Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications Physiol Rev, April 1, 2006; 86(2): 583 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wu and R. Wang Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications Pharmacol. Rev., December 1, 2005; 57(4): 585 - 630. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Sarady-Andrews, F. Liu, D. Gallo, A. Nakao, M. Overhaus, R. Ollinger, A. M. Choi, and L. E. Otterbein Biliverdin administration protects against endotoxin-induced acute lung injury in rats Am J Physiol Lung Cell Mol Physiol, December 1, 2005; 289(6): L1131 - L1137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. O. Berberat, Z. Dambrauskas, A. Gulbinas, T. Giese, N. Giese, B. Kunzli, F. Autschbach, S. Meuer, M. W. Buchler, and H. Friess Inhibition of Heme Oxygenase-1 Increases Responsiveness of Pancreatic Cancer Cells to Anticancer Treatment Clin. Cancer Res., May 15, 2005; 11(10): 3790 - 3798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Boehning, D. B. van Rossum, R. L. Patterson, and S. H. Snyder A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor binding blocks intrinsic and extrinsic cell death pathways PNAS, February 1, 2005; 102(5): 1466 - 1471. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Boehning, L. Sedaghat, T. W. Sedlak, and S. H. Snyder Heme Oxygenase-2 Is Activated by Calcium-Calmodulin J. Biol. Chem., July 23, 2004; 279(30): 30927 - 30930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. P. KIM, X. WANG, F. GALBIATI, S. W. RYTER, and A. M. K. CHOI Caveolae compartmentalization of heme oxygenase-1 in endothelial cells FASEB J, July 1, 2004; 18(10): 1080 - 1089. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. W. Sedlak and S. H. Snyder Bilirubin Benefits: Cellular Protection by a Biliverdin Reductase Antioxidant Cycle Pediatrics, June 1, 2004; 113(6): 1776 - 1782. [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Soares, M. P. Seldon, I. P. Gregoire, T. Vassilevskaia, P. O. Berberat, J. Yu, T.-Y. Tsui, and F. H. Bach Heme Oxygenase-1 Modulates the Expression of Adhesion Molecules Associated with Endothelial Cell Activation J. Immunol., March 15, 2004; 172(6): 3553 - 3563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. C. Watkins, D. Boehning, A. I. Kaplin, M. Rao, C. D. Ferris, and S. H. Snyder Carbon monoxide mediates vasoactive intestinal polypeptide-associated nonadrenergic/noncholinergic neurotransmission PNAS, February 24, 2004; 101(8): 2631 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. A. D. T. G. Wagener, H.-D. Volk, D. Willis, N. G. Abraham, M. P. Soares, G. J. Adema, and C. G. Figdor Different Faces of the Heme-Heme Oxygenase System in Inflammation Pharmacol. Rev., September 1, 2003; 55(3): 551 - 571. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. K. R. Kanakiriya, A. J. Croatt, J. J. Haggard, J. R. Ingelfinger, S.-S. Tang, J. Alam, and K. A. Nath Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms Am J Physiol Renal Physiol, March 1, 2003; 284(3): F546 - F554. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. J. Kress, K. E. Dineley, and I. J. Reynolds The Relationship between Intracellular Free Iron and Cell Injury in Cultured Neurons, Astrocytes, and Oligodendrocytes J. Neurosci., July 15, 2002; 22(14): 5848 - 5855. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. E. Baranano and S. H. Snyder Neural roles for heme oxygenase: Contrasts to nitric oxide synthase PNAS, September 25, 2001; 98(20): 10996 - 11002. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. E. Otterbein and A. M. K. Choi Heme oxygenase: colors of defense against cellular stress Am J Physiol Lung Cell Mol Physiol, December 1, 2000; 279(6): L1029 - L1037. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Brittenham, G. Weiss, P. Brissot, F. Laine, A. Guillygomarc'h, D. Guyader, R. Moirand, and Y. Deugnier Clinical Consequences of New Insights in the Pathophysiology of Disorders of Iron and Heme Metabolism Hematology, January 1, 2000; 2000(1): 39 - 50. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
