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J Biol Chem, Vol. 275, Issue 20, 15336-15342, May 19, 2000
From the We have isolated a novel member of the TNFR
family, designated TAJ, that is highly expressed during embryonic
development. TAJ possesses a unique cytoplasmic domain with no sequence
homology to the previously characterized members of the TNFR family.
TAJ interacts with the TRAF family members and activates the JNK
pathway when overexpressed in mammalian cells. Although it lacks a
death domain, TAJ is capable of inducing apoptosis by a
caspase-independent mechanism. Based on its unique expression profile
and signaling properties, TAJ may play an essential role in embryonic development.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF167552-AF167555.
TAJ, a Novel Member of the Tumor Necrosis Factor Receptor Family,
Activates the c-Jun N-terminal Kinase Pathway and Mediates
Caspase-independent Cell Death*
,,,¶
Hamon Center for Therapeutic Oncology
Research, University of Texas Southwestern Medical Center,
Dallas, Texas 75390-8593 and the § University of
Washington, Seattle, Washington 98195
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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