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J. Biol. Chem., Vol. 275, Issue 21, 15685-15690, May 26, 2000
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From the The ZNF202 gene resides in a chromosomal region
linked genetically to low high density lipoprotein
cholesterol in Utah families. Here we show that the ZNF202 gene product
is a transcriptional repressor that binds to elements found
predominantly in genes that participate in lipid metabolism. Among its
targets are structural components of lipoprotein particles
(apolipoproteins AIV, CIII, and E), enzymes involved in lipid
processing (lipoprotein lipase, lecithin cholesteryl ester
transferase), and several genes involved in processes related to energy
metabolism and vascular disease. Based on the linkage and apparent
transcriptional function of ZNF202, we propose that ZNF202 is a
candidate susceptibility gene for human dyslipidemia.
Myriad Genetics, Inc., Salt Lake City, Utah
84108 and ¶ Novartis Institute for Biomedical Research,
Summit, New Jersey 07901
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