| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 275, Issue 21, 16091-16097, May 26, 2000
From the Fibroblast growth factors (FGFs) transmit their
signals through four transmembrane receptors that are designated
FGFR1-4. Alternative splicing in the extracellular region of FGFR1-3
generates receptor variants with different ligand binding affinities.
Thus two types of transmembrane receptors (IIIb and IIIc isoforms) have
been identified for FGFR2 and FGFR3, and the existence of analogous
variants has been postulated for FGFR1 based on its genomic structure.
However, only a single full-length transmembrane FGFR1 variant
(FGFR1-IIIc) has been identified so far. Here we describe the cloning
of a full-length cDNA encoding FGFR1-IIIb from a mouse skin wound
cDNA library. This receptor isoform was expressed at the highest
levels in a subset of sebaceous glands of the skin and in neurons of
the hippocampus and the cerebellum. FGFR1-IIIb was expressed in L6 rat
skeletal muscle myoblasts and used in cross-linking and receptor
binding studies. FGF-1 was found to bind the receptor with high
affinity, whereas FGF-2, -10, and -7 bound with significantly lower
affinities. Despite their apparently similar but low affinities, FGF-10
but not FGF-7 induced the activation of p44/42 mitogen-activated
protein kinase in FGFR1-IIIb-expressing L6 myoblasts and stimulated
mitogenesis in these cells, demonstrating that this new receptor
variant is a functional transmembrane receptor for FGF-10.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF176552.
Fibroblast Growth Factor (FGF) Receptor 1-IIIb Is a Naturally
Occurring Functional Receptor for FGFs That Is Preferentially Expressed
in the Skin and the Brain*
,,
,**
Institute of Cell Biology, Swiss Federal
Institute of Technology, CH-8093 Zürich, Switzerland, the
§ Department of Developmental Neurobiology, New Hunt's
House, King's College London, London SE1 9RT, United Kingdom, the
¶ Imperial Cancer Research Fund, London WC2A 3PX, United Kingdom,
and Human Genome Sciences, Inc., Rockville, Maryland 20850
*
This work was supported by the Human Frontier Science
Program (to S. W., C. D., and I. M.) and the
Bundesministerium für Bildung und Forschung (to S. W.).The costs of publication of this article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  Z. Liu, N. Neiss, S. Zhou, D. Henne-Bruns, M. Korc, M. Bachem, and M. Kornmann Identification of a Fibroblast Growth Factor Receptor 1 Splice Variant That Inhibits Pancreatic Cancer Cell Growth Cancer Res., March 15, 2007; 67(6): 2712 - 2719. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. D. Sun, M. Malabunga, J. R. Tonra, R. DiRenzo, F. E. Carrick, H. Zheng, H.-R. Berthoud, O. P. McGuinness, J. Shen, P. Bohlen, et al. Monoclonal antibody antagonists of hypothalamic FGFR1 cause potent but reversible hypophagia and weight loss in rodents and monkeys Am J Physiol Endocrinol Metab, March 1, 2007; 292(3): E964 - E976. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Zhang, O. A. Ibrahimi, S. K. Olsen, H. Umemori, M. Mohammadi, and D. M. Ornitz Receptor Specificity of the Fibroblast Growth Factor Family: THE COMPLETE MAMMALIAN FGF FAMILY J. Biol. Chem., June 9, 2006; 281(23): 15694 - 15700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Kessaris, F. Jamen, L. L. Rubin, and W. D. Richardson Cooperation between sonic hedgehog and fibroblast growth factor/MAPK signalling pathways in neocortical precursors Development, March 15, 2004; 131(6): 1289 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Alvarez, M. T. Alonso, V. Vendrell, L. C. Zelarayan, P. Chamero, T. Theil, M. R. Bosl, S. Kato, M. Maconochie, D. Riethmacher, et al. Requirements for FGF3 and FGF10 during inner ear formation Development, December 22, 2003; 130(25): 6329 - 6338. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Wright and S. L. Mansour Fgf3 and Fgf10 are required for mouse otic placode induction Development, August 1, 2003; 130(15): 3379 - 3390. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. P. Eswarakumar, E. Monsonego-Ornan, M. Pines, I. Antonopoulou, G. M. Morriss-Kay, and P. Lonai The IIIc alternative of Fgfr2 is a positive regulator of bone formation Development, March 10, 2003; 129(16): 3783 - 3793. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. K. Yeh, M. Igarashi, A. V. Eliseenkova, A. N. Plotnikov, I. Sher, D. Ron, S. A. Aaronson, and M. Mohammadi Structural basis by which alternative splicing confers specificity in fibroblast growth factor receptors PNAS, March 4, 2003; 100(5): 2266 - 2271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. J. Muh, R. H. Hovhannisyan, and R. P. Carstens A Non-sequence-specific Double-stranded RNA Structural Element Regulates Splicing of Two Mutually Exclusive Exons of Fibroblast Growth Factor Receptor 2 (FGFR2) J. Biol. Chem., December 13, 2002; 277(51): 50143 - 50154. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. B. Ware and M. A. Matthay Keratinocyte and hepatocyte growth factors in the lung: roles in lung development, inflammation, and repair Am J Physiol Lung Cell Mol Physiol, May 1, 2002; 282(5): L924 - L940. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
