JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M910179199 on March 22, 2000

J. Biol. Chem., Vol. 275, Issue 21, 16258-16266, May 26, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/21/16258    most recent
M910179199v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Vidal-Puig, A. J.
Right arrow Articles by Lowell, B. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vidal-Puig, A. J.
Right arrow Articles by Lowell, B. B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Energy Metabolism in Uncoupling Protein 3 Gene Knockout Mice*

Antonio J. Vidal-PuigDagger §, Danica GrujicDagger , Chen-Yu ZhangDagger , Thilo HagenDagger , Olivier BossDagger , Yasuo Ido, Alicja SzczepanikDagger , Jennifer WadeDagger , Vamsi MoothaDagger , Ronald Cortright||, Deborah M. Muoio||, and Bradford B. LowellDagger **

From the Dagger  Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, || Departments of Exercise and Sports Science Physiology and Biochemistry, School of Medicine, East Carolina University, Greenville, North Carolina 27858, and  Diabetes and Metabolism Unit, Boston Medical Center, Boston, Massachusetts 02118

Uncoupling protein 3 (UCP3) is a member of the mitochondrial anion carrier superfamily. Based upon its high homology with UCP1 and its restricted tissue distribution to skeletal muscle and brown adipose tissue, UCP3 has been suggested to play important roles in regulating energy expenditure, body weight, and thermoregulation. Other postulated roles for UCP3 include regulation of fatty acid metabolism, adaptive responses to acute exercise and starvation, and prevention of reactive oxygen species (ROS) formation. To address these questions, we have generated mice lacking UCP3 (UCP3 knockout (KO) mice). Here, we provide evidence that skeletal muscle mitochondria lacking UCP3 are more coupled (i.e. increased state 3/state 4 ratio), indicating that UCP3 has uncoupling activity. In addition, production of ROS is increased in mitochondria lacking UCP3. This study demonstrates that UCP3 has uncoupling activity and that its absence may lead to increased production of ROS. Despite these effects on mitochondrial function, UCP3 does not seem to be required for body weight regulation, exercise tolerance, fatty acid oxidation, or cold-induced thermogenesis. The absence of such phenotypes in UCP3 KO mice could not be attributed to up-regulation of other UCP mRNAs. However, alternative compensatory mechanisms cannot be excluded. The consequence of increased mitochondrial coupling in UCP3 KO mice on metabolism and the possible role of yet unidentified compensatory mechanisms, remains to be determined.

* This work was supported by National Institutes of Health Grant DK49569 (to B. B. L.), a grant from Lilly (to B. B. L.), Boston Obesity Nutrition Research Center (BONRC) Pilot Project Award P30 DK46200 (to A. V.-P.), BONRC Transgenic Core Grant P30 DK46200, and Human Frontier Science Program Grant LT 0020/1999 (to O. B.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ Present address: University of Cambridge, Depts. of Clinical Biochemistry and Medicine, Addenbrooke's Hospital, Box 232, Cambridge CB2 2QR, UK.

** To whom correspondence should be addressed: Beth Israel Deaconess Medical Center, Endocrine Division, Research North Rm., 99 Brookline Ave., Boston, MA 02215. Tel.: 617-667-5954; Fax: 617-667-2927; E-mail: blowell@caregroup.harvard.edu.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 DiabetesHome page
Z. Xie, J. Zhang, J. Wu, B. Viollet, and M.-H. Zou
Upregulation of Mitochondrial Uncoupling Protein-2 by the AMP-Activated Protein Kinase in Endothelial Cells Attenuates Oxidative Stress in Diabetes
Diabetes, December 1, 2008; 57(12): 3222 - 3230.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
C. S Wyrwoll, P. J Mark, T. A Mori, and B. J Waddell
Developmental programming of adult hyperinsulinemia, increased proinflammatory cytokine production, and altered skeletal muscle expression of SLC2A4 (GLUT4) and uncoupling protein 3
J. Endocrinol., September 1, 2008; 198(3): 571 - 579.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Lu and M. N. Sack
ATF-1 Is a Hypoxia-responsive Transcriptional Activator of Skeletal Muscle Mitochondrial-uncoupling Protein 3
J. Biol. Chem., August 22, 2008; 283(34): 23410 - 23418.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Hummasti and P. Tontonoz
Adopting New Orphans into the Family of Metabolic Regulators
Mol. Endocrinol., August 1, 2008; 22(8): 1743 - 1753.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Rey, L. G. Halsey, V. Dolmazon, J.-L. Rouanet, D. Roussel, Y. Handrich, P. J. Butler, and C. Duchamp
Long-term fasting decreases mitochondrial avian UCP-mediated oxygen consumption in hypometabolic king penguins
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2008; 295(1): R92 - R100.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Biol.Home page
B. Rey, B. Sibille, C. Romestaing, M. Belouze, D. Letexier, S. Servais, H. Barre, C. Duchamp, and Y. Voituron
Reptilian uncoupling protein: functionality and expression in sub-zero temperatures
J. Exp. Biol., May 1, 2008; 211(9): 1456 - 1462.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
N. Tsuboyama-Kasaoka, K. Sano, C. Shozawa, T. Osaka, and O. Ezaki
Studies of UCP2 transgenic and knockout mice reveal that liver UCP2 is not essential for the antiobesity effects of fish oil
Am J Physiol Endocrinol Metab, March 1, 2008; 294(3): E600 - E606.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
J.-a Kim, Y. Wei, and J. R. Sowers
Role of Mitochondrial Dysfunction in Insulin Resistance
Circ. Res., February 29, 2008; 102(4): 401 - 414.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
E. L. Sherman, J. D. Nkrumah, B. M. Murdoch, C. Li, Z. Wang, A. Fu, and S. S. Moore
Polymorphisms and haplotypes in the bovine neuropeptide Y, growth hormone receptor, ghrelin, insulin-like growth factor 2, and uncoupling proteins 2 and 3 genes and their associations with measures of growth, performance, feed efficiency, and carcass merit in beef cattle
J Anim Sci, January 1, 2008; 86(1): 1 - 16.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. J. Anderson, H. Yamazaki, and P. D. Neufer
Induction of Endogenous Uncoupling Protein 3 Suppresses Mitochondrial Oxidant Emission during Fatty Acid-supported Respiration
J. Biol. Chem., October 26, 2007; 282(43): 31257 - 31266.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
P. R. Cutillas and B. Vanhaesebroeck
Quantitative Profile of Five Murine Core Proteomes Using Label-free Functional Proteomics
Mol. Cell. Proteomics, September 1, 2007; 6(9): 1560 - 1573.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
S. Raichur, P. Lau, B. Staels, and G. E O Muscat
Retinoid-related orphan receptor {gamma} regulates several genes that control metabolism in skeletal muscle cells: links to modulation of reactive oxygen species production
J. Mol. Endocrinol., July 1, 2007; 39(1): 29 - 44.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
B. Faraut, B. Giannesini, V. Matarazzo, T. Marqueste, C. Dalmasso, G. Rougon, P. J. Cozzone, and D. Bendahan
Downregulation of uncoupling protein-3 in vivo is linked to changes in muscle mitochondrial energy metabolism as a result of capsiate administration
Am J Physiol Endocrinol Metab, May 1, 2007; 292(5): E1474 - E1482.
[Abstract] [Full Text] [PDF]

Home page
 Poult. Sci.Home page
A. Mujahid, Y. Akiba, and M. Toyomizu
Acute Heat Stress Induces Oxidative Stress and Decreases Adaptation in Young White Leghorn Cockerels by Downregulation of Avian Uncoupling Protein
Poult. Sci., February 1, 2007; 86(2): 364 - 371.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
V. Bezaire, E. L. Seifert, and M.-E. Harper
Uncoupling protein-3: clues in an ongoing mitochondrial mystery
FASEB J, February 1, 2007; 21(2): 312 - 324.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. A. Pearen, J. G. Ryall, M. A. Maxwell, N. Ohkura, G. S. Lynch, and G. E. O. Muscat
The Orphan Nuclear Receptor, NOR-1, Is a Target of {beta}-Adrenergic Signaling in Skeletal Muscle
Endocrinology, November 1, 2006; 147(11): 5217 - 5227.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
N. Pedraza, M. Rosell, J. Villarroya, R. Iglesias, F. J. Gonzalez, G. Solanes, and F. Villarroya
Developmental and Tissue-Specific Involvement of Peroxisome Proliferator-Activated Receptor-{alpha} in the Control of Mouse Uncoupling Protein-3 Gene Expression
Endocrinology, October 1, 2006; 147(10): 4695 - 4704.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
S. Boudina and E. D. Abel
Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.
Physiology, August 1, 2006; 21: 250 - 258.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. W. Cline
Tough love: left out in the cold, but not abandoned, by UCP3
J Appl Physiol, July 1, 2006; 101(1): 12 - 13.
[Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. L. Barger, B. M. Barnes, and B. B. Boyer
Regulation of UCP1 and UCP3 in arctic ground squirrels and relation with mitochondrial proton leak
J Appl Physiol, July 1, 2006; 101(1): 339 - 347.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
D. R. Gable, J. W. Stephens, J. A. Cooper, G. J. Miller, and S. E. Humphries
Variation in the UCP2-UCP3 Gene Cluster Predicts the Development of Type 2 Diabetes in Healthy Middle-Aged Men.
Diabetes, May 1, 2006; 55(5): 1504 - 1511.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. E. Silva
Thermogenic Mechanisms and Their Hormonal Regulation
Physiol Rev, April 1, 2006; 86(2): 435 - 464.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Mogensen, M. Bagger, P. K. Pedersen, M. Fernstrom, and K. Sahlin
Cycling efficiency in humans is related to low UCP3 content and to type I fibres but not to mitochondrial efficiency
J. Physiol., March 15, 2006; 571(3): 669 - 681.
[Abstract] [Full Text] [PDF]

Home page
 Diabetes CareHome page
G. Rudofsky Jr, A. Schroedter, A. Schlotterer, O. E. Voron'ko, M. Schlimme, J. Tafel, B. H. Isermann, P. M. Humpert, M. Morcos, A. Bierhaus, et al.
Functional Polymorphisms of UCP2 and UCP3 Are Associated With a Reduced Prevalence of Diabetic Neuropathy in Patients With Type 1 Diabetes
Diabetes Care, January 1, 2006; 29(1): 89 - 94.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
S. Boudina, S. Sena, B. T. O'Neill, P. Tathireddy, M. E. Young, and E. D. Abel
Reduced Mitochondrial Oxidative Capacity and Increased Mitochondrial Uncoupling Impair Myocardial Energetics in Obesity
Circulation, October 25, 2005; 112(17): 2686 - 2695.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
A. Couillard and C. Prefaut
From muscle disuse to myopathy in COPD: potential contribution of oxidative stress
Eur. Respir. J., October 1, 2005; 26(4): 703 - 719.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
L. Bevilacqua, J. J. Ramsey, K. Hagopian, R. Weindruch, and M.-E. Harper
Long-term caloric restriction increases UCP3 content but decreases proton leak and reactive oxygen species production in rat skeletal muscle mitochondria
Am J Physiol Endocrinol Metab, September 1, 2005; 289(3): E429 - E438.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. D. MacLellan, M. F. Gerrits, A. Gowing, P. J.S. Smith, M. B. Wheeler, and M.-E. Harper
Physiological Increases in Uncoupling Protein 3 Augment Fatty Acid Oxidation and Decrease Reactive Oxygen Species Production Without Uncoupling Respiration in Muscle Cells
Diabetes, August 1, 2005; 54(8): 2343 - 2350.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
Y.-J. Liu, P.-Y. Liu, J. Long, Y. Lu, L. Elze, R. R. Recker, and H.-W. Deng
Linkage and association analyses of the UCP3 gene with obesity phenotypes in Caucasian families
Physiol Genomics, July 14, 2005; 22(2): 197 - 203.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
W. C. Stanley, F. A. Recchia, and G. D. Lopaschuk
Myocardial Substrate Metabolism in the Normal and Failing Heart
Physiol Rev, July 1, 2005; 85(3): 1093 - 1129.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
G. Medina-Gomez, S. Virtue, C. Lelliott, R. Boiani, M. Campbell, C. Christodoulides, C. Perrin, M. Jimenez-Linan, M. Blount, J. Dixon, et al.
The Link Between Nutritional Status and Insulin Sensitivity Is Dependent on the Adipocyte-Specific Peroxisome Proliferator-Activated Receptor-{gamma}2 Isoform
Diabetes, June 1, 2005; 54(6): 1706 - 1716.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. M. Carroll, L. R. Haines, T. W. Pearson, P. G. Fallon, C. M. Walsh, C. M. Brennan, E. P. Breen, and R. K. Porter
Identification of a Functioning Mitochondrial Uncoupling Protein 1 in Thymus
J. Biol. Chem., April 22, 2005; 280(16): 15534 - 15543.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Shi, F. Wang, E. Stieren, and Q. Tong
SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes
J. Biol. Chem., April 8, 2005; 280(14): 13560 - 13567.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. A. Maxwell, M. E. Cleasby, A. Harding, A. Stark, G. J. Cooney, and G. E. O. Muscat
Nur77 Regulates Lipolysis in Skeletal Muscle Cells: EVIDENCE FOR CROSS-TALK BETWEEN THE {beta}-ADRENERGIC AND AN ORPHAN NUCLEAR HORMONE RECEPTOR PATHWAY
J. Biol. Chem., April 1, 2005; 280(13): 12573 - 12584.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
Y. Ishigaki, H. Katagiri, T. Yamada, T. Ogihara, J. Imai, K. Uno, Y. Hasegawa, J. Gao, H. Ishihara, T. Shimosegawa, et al.
Dissipating Excess Energy Stored in the Liver Is a Potential Treatment Strategy for Diabetes Associated With Obesity
Diabetes, February 1, 2005; 54(2): 322 - 332.
[Abstract] [Full Text] [PDF]

Home page
 J ANIM SCIHome page
M. Katsumata, M. Matsumoto, S. Kawakami, and Y. Kaji
Effect of heat exposure on uncoupling protein-3 mRNA abundance in porcine skeletal muscle
J Anim Sci, December 1, 2004; 82(12): 3493 - 3499.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. T. Putman, W. T. Dixon, J. A. Pearcey, I. M. MacLean, M. J. Jendral, M. Kiricsi, G. K. Murdoch, and D. Pette
Chronic low-frequency stimulation upregulates uncoupling protein-3 in transforming rat fast-twitch skeletal muscle
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2004; 287(6): R1419 - R1426.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
H. B. Suliman, K. E. Welty-Wolf, M. Carraway, L. Tatro, and C. A. Piantadosi
Lipopolysaccharide induces oxidative cardiac mitochondrial damage and biogenesis
Cardiovasc Res, November 1, 2004; 64(2): 279 - 288.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
V. Ljubicic, P. J. Adhihetty, and D. A. Hood
Role of UCP3 in state 4 respiration during contractile activity-induced mitochondrial biogenesis
J Appl Physiol, September 1, 2004; 97(3): 976 - 983.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
K. S. Nair, A. Jaleel, Y. W. Asmann, K. R. Short, and S. Raghavakaimal
Proteomic research: potential opportunities for clinical and physiological investigators
Am J Physiol Endocrinol Metab, June 1, 2004; 286(6): E863 - E874.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
P. Schrauwen and M. K.C. Hesselink
Oxidative Capacity, Lipotoxicity, and Mitochondrial Damage in Type 2 Diabetes
Diabetes, June 1, 2004; 53(6): 1412 - 1417.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. M. Vincent, J. A. Olzmann, M. Brownlee, W.I. Sivitz, and J. W. Russell
Uncoupling Proteins Prevent Glucose-Induced Neuronal Oxidative Stress and Programmed Cell Death
Diabetes, March 1, 2004; 53(3): 726 - 734.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
M. Fernstrom, M. Tonkonogi, and K. Sahlin
Effects of acute and chronic endurance exercise on mitochondrial uncoupling in human skeletal muscle
J. Physiol., February 1, 2004; 554(3): 755 - 763.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. A. Maassen, Leen. M. 't Hart, E. van Essen, R. J. Heine, G. Nijpels, R. S. Jahangir Tafrechi, A. K. Raap, G. M.C. Janssen, and H. H.P.J. Lemkes
Mitochondrial Diabetes: Molecular Mechanisms and Clinical Presentation
Diabetes, February 1, 2004; 53(90001): S103 - 109.
[Abstract] [Full Text]

Home page
 DiabetesHome page
S. Rousset, M.-C. Alves-Guerra, J. Mozo, B. Miroux, A.-M. Cassard-Doulcier, F. Bouillaud, and D. Ricquier
The Biology of Mitochondrial Uncoupling Proteins
Diabetes, February 1, 2004; 53(90001): S130 - 135.
[Abstract] [Full Text]

Home page
 Physiol. Rev.Home page
B. CANNON and J. NEDERGAARD
Brown Adipose Tissue: Function and Physiological Significance
Physiol Rev, January 1, 2004; 84(1): 277 - 359.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. P. Murphy, K. S. Echtay, F. H. Blaikie, J. Asin-Cayuela, H. M. Cocheme, K. Green, J. A. Buckingham, E. R. Taylor, F. Hurrell, G. Hughes, et al.
Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation: STUDIES USING A MITOCHONDRIA-TARGETED SPIN TRAP DERIVED FROM {alpha}-PHENYL-N-tert-BUTYLNITRONE
J. Biol. Chem., December 5, 2003; 278(49): 48534 - 48545.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
A. Porras, S. Zuluaga, A. Valladares, A. M. Alvarez, B. Herrera, I. Fabregat, and M. Benito
Long-Term Treatment with Insulin Induces Apoptosis in Brown Adipocytes: Role of Oxidative Stress
Endocrinology, December 1, 2003; 144(12): 5390 - 5401.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. L. Hildebrandt, H. Pilegaard, and P. D. Neufer
Differential transcriptional activation of select metabolic genes in response to variations in exercise intensity and duration
Am J Physiol Endocrinol Metab, November 1, 2003; 285(5): E1021 - E1027.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-C. Alves-Guerra, S. Rousset, C. Pecqueur, Z. Mallat, J. Blanc, A. Tedgui, F. Bouillaud, A.-M. Cassard-Doulcier, D. Ricquier, and B. Miroux
Bone Marrow Transplantation Reveals the in Vivo Expression of the Mitochondrial Uncoupling Protein 2 in Immune and Nonimmune Cells during Inflammation
J. Biol. Chem., October 24, 2003; 278(43): 42307 - 42312.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. A. Zaninovich, I. Rebagliati, M. Raices, C. Ricci, and K. Hagmuller
Mitochondrial respiration in muscle and liver from cold-acclimated hypothyroid rats
J Appl Physiol, October 1, 2003; 95(4): 1584 - 1590.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
G. Solanes, N. Pedraza, R. Iglesias, M. Giralt, and F. Villarroya
Functional Relationship between MyoD and Peroxisome Proliferator-Activated Receptor-Dependent Regulatory Pathways in the Control of the Human Uncoupling Protein-3 Gene Transcription
Mol. Endocrinol., October 1, 2003; 17(10): 1944 - 1958.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. M. Rodriguez, P. Roca, M. L. Bonet, C. Pico, P. Oliver, and A. Palou
Positive correlation of skeletal muscle UCP3 mRNA levels with overweight in male, but not in female, rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R880 - R888.
[Abstract] [Full Text] [PDF]

Home page