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J. Biol. Chem., Vol. 275, Issue 22, 16404-16407, June 2, 2000

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ACCELERATED PUBLICATION
pH Dependence of the Inwardly Rectifying Potassium Channel, Kir5.1, and Localization in Renal Tubular Epithelia^*

Stephen J. Tucker^§, Paola Imbrici^¶, Lorena Salvatore^**, Maria Cristina D'Adamo^¶, and Mauro Pessia^¶

From the  University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom and the Departments of ^¶ Vascular Medicine and Pharmacology and ^** Molecular Pharmacology and Pathology, Istituto di Ricerche Farmacologiche "Mario Negri," Consorzio Mario Negri Sud, 66030 Santa Maria Imbaro (Chieti), Italy

The physiological role of the inwardly rectifying potassium channel, Kir5.1, is poorly understood, as is the molecular identity of many renal potassium channels. In this study we have used Kir5.1-specific antibodies to reveal abundant expression of Kir5.1 in renal tubular epithelial cells, where Kir4.1 is also expressed. Moreover, we also show that Kir5.1/Kir4.1 heteromeric channel activity is extremely sensitive to inhibition by intracellular acidification and that this novel property is conferred predominantly by the Kir5.1 subunit. These findings suggest that Kir5.1/Kir4.1 heteromeric channels are likely to exist in vivo and implicate an important and novel functional role for the Kir5.1 subunit.

The nucleotide sequence(s) reported in this paper has been submitted to the GenBank^TM/EMBL Data Bank with accession number(s) AF249676.

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