JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M000287200 on April 3, 2000

J. Biol. Chem., Vol. 275, Issue 22, 16690-16696, June 2, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/22/16690    most recent
M000287200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kanoh, Y.
Right arrow Articles by Farese, R. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kanoh, Y.
Right arrow Articles by Farese, R. V.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Thiazolidinedione Treatment Enhances Insulin Effects on Protein Kinase C-zeta /lambda Activation and Glucose Transport in Adipocytes of Nondiabetic and Goto-Kakizaki Type II Diabetic Rats*

Yoshinori Kanoh, Gautam Bandyopadhyay, Mini P. Sajan, Mary L. Standaert, and Robert V. FareseDagger

From the J. A. Haley Veterans Hospital Research Service and Department of Internal Medicine, University of South Florida College of Medicine Tampa, FL 33612

We evaluated effects of the thiazolidinedione, rosiglitazone, on insulin-induced activation of protein kinase C (PKC)-zeta /lambda and glucose transport in adipocytes of Goto-Kakizaki (GK)-diabetic and nondiabetic rats. Insulin effects on PKC-zeta /lambda and 2-deoxyglucose uptake were diminished by approximately 50% in GK adipocytes, as compared with control adipocytes. This defect in insulin-induced PKC-zeta /lambda activation was associated with diminished activation of IRS-1-dependent phosphatidylinositol (PI) 3-kinase, and was accompanied by diminished phosphorylation of threonine 410 in the activation loop of PKC-zeta ; in contrast, protein kinase B (PKB) activation and phosphorylation were not significantly altered. Rosiglitazone completely reversed defects in insulin-stimulated 2-deoxyglucose uptake, PKCzeta /lambda enzyme activity and PKC-zeta threonine 410 phosphorylation, but had no effect on PI 3-kinase activation or PKB activation/phosphorylation in GK adipocytes. Similarly, in adipocytes of nondiabetic rats, rosiglitazone provoked increases in insulin-stimulated 2-deoxyglucose uptake, PKC-zeta /lambda enzyme activity and phosphorylation of both threonine 410 activation loop and threonine 560 autophosphorylation sites in PKC-zeta , but had no effect on PI 3-kinase activation or PKB activation/phosphorylation. Our findings suggest that (a) decreased effects of insulin on glucose transport in adipocytes of GK-diabetic rats are due at least in part to diminished phosphorylation/activation of PKC-zeta /lambda , and (b) thiazolidinediones enhance glucose transport responses to insulin in adipocytes of both diabetic and nondiabetic rats through increases in phosphorylation/activation of PKC-zeta /lambda .

* This work was supported by funds from the Department of Veterans Affairs Merit Review Program and National Institutes of Health Research Grant 2R01DK38079-09A1.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Research Service (VAR 151), J. A. Haley Veterans Hospital, 13000 Bruce B. Downs Blvd., Tampa, FL 33612. Tel.: 813-972-7662; Fax: 813-972-7623; E-mail: rfarese@com1.med.usf.edu.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Exp. Biol. Med.Home page
R. V. Farese, M. P. Sajan, and M. L. Standaert
Insulin-Sensitive Protein Kinases (Atypical Protein Kinase C and Protein Kinase B/Akt): Actions and Defects in Obesity and Type II Diabetes
Experimental Biology and Medicine, October 1, 2005; 230(9): 593 - 605.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. P. Sajan, M. L. Standaert, A. Miura, C. R. Kahn, and R. V. Farese
Tissue-Specific Differences in Activation of Atypical Protein Kinase C and Protein Kinase B in Muscle, Liver, and Adipocytes of Insulin Receptor Substrate-1 Knockout Mice
Mol. Endocrinol., October 1, 2004; 18(10): 2513 - 2521.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. P. Sajan, M. L. Standaert, A. Miura, G. Bandyopadhyay, P. Vollenweider, D. M. Franklin, R. Lea-Currie, and R. V. Farese
Impaired Activation of Protein Kinase C-{zeta} by Insulin and Phosphatidylinositol-3,4,5-(PO4)3 in Cultured Preadipocyte-Derived Adipocytes and Myotubes of Obese Subjects
J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3994 - 3998.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. L. Standaert, M. P. Sajan, A. Miura, Y. Kanoh, H. C. Chen, R. V. Farese Jr., and R. V. Farese
Insulin-induced Activation of Atypical Protein Kinase C, but Not Protein Kinase B, Is Maintained in Diabetic (ob/ob and Goto-Kakazaki) Liver: CONTRASTING INSULIN SIGNALING PATTERNS IN LIVER VERSUS MUSCLE DEFINE PHENOTYPES OF TYPE 2 DIABETIC AND HIGH FAT-INDUCED INSULIN-RESISTANT STATES
J. Biol. Chem., June 11, 2004; 279(24): 24929 - 24934.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
E. Verrier, L. Wang, C. Wadham, N. Albanese, C. Hahn, J. R. Gamble, V. K. K. Chatterjee, M. A. Vadas, and P. Xia
PPAR{gamma} Agonists Ameliorate Endothelial Cell Activation via Inhibition of Diacylglycerol-Protein Kinase C Signaling Pathway: Role of Diacylglycerol Kinase
Circ. Res., June 11, 2004; 94(11): 1515 - 1522.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. M. Zabolotny, F. G. Haj, Y.-B. Kim, H.-J. Kim, G. I. Shulman, J. K. Kim, B. G. Neel, and B. B. Kahn
Transgenic Overexpression of Protein-tyrosine Phosphatase 1B in Muscle Causes Insulin Resistance, but Overexpression with Leukocyte Antigen-related Phosphatase Does Not Additively Impair Insulin Action
J. Biol. Chem., June 4, 2004; 279(23): 24844 - 24851.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
G. Vigliotta, C. Miele, S. Santopietro, G. Portella, A. Perfetti, M. A. Maitan, A. Cassese, F. Oriente, A. Trencia, F. Fiory, et al.
Overexpression of the ped/pea-15 Gene Causes Diabetes by Impairing Glucose-Stimulated Insulin Secretion in Addition to Insulin Action
Mol. Cell. Biol., June 1, 2004; 24(11): 5005 - 5015.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H. C. Chen, M. Rao, M. P. Sajan, M. Standaert, Y. Kanoh, A. Miura, R. V. Farese Jr., and R. V. Farese
Role of Adipocyte-Derived Factors in Enhancing Insulin Signaling in Skeletal Muscle and White Adipose Tissue of Mice Lacking Acyl CoA:Diacylglycerol Acyltransferase 1
Diabetes, June 1, 2004; 53(6): 1445 - 1451.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
G. Bandyopadhyay, M. L. Standaert, M. P. Sajan, Y. Kanoh, A. Miura, U. Braun, F. Kruse, M. Leitges, and R. V. Farese
Protein Kinase C-{lambda} Knockout in Embryonic Stem Cells and Adipocytes Impairs Insulin-Stimulated Glucose Transport
Mol. Endocrinol., February 1, 2004; 18(2): 373 - 383.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. Song, M. A. Knepper, X. Hu, J. G. Verbalis, and C. A. Ecelbarger
Rosiglitazone Activates Renal Sodium- and Water-Reabsorptive Pathways and Lowers Blood Pressure in Normal Rats
J. Pharmacol. Exp. Ther., February 1, 2004; 308(2): 426 - 433.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
M. Desrois, R. J Sidell, D. Gauguier, L. M King, G. K Radda, and K. Clarke
Initial steps of insulin signaling and glucose transport are defective in the type 2 diabetic rat heart
Cardiovasc Res, February 1, 2004; 61(2): 288 - 296.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
Y.-B. Kim, K. Kotani, T. P. Ciaraldi, R. R. Henry, and B. B. Kahn
Insulin-Stimulated Protein Kinase C {lambda}/{zeta} Activity Is Reduced in Skeletal Muscle of Humans With Obesity and Type 2 Diabetes: Reversal With Weight Reduction
Diabetes, August 1, 2003; 52(8): 1935 - 1942.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Kanoh, M. P. Sajan, G. Bandyopadhyay, A. Miura, M. L. Standaert, and R. V. Farese
Defective Activation of Atypical Protein Kinase C {zeta} and {lambda} by Insulin and Phosphatidylinositol-3,4,5-(PO4)3 in Skeletal Muscle of Rats Following High-Fat Feeding and Streptozotocin-Induced Diabetes
Endocrinology, March 1, 2003; 144(3): 947 - 954.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
M. M. Meyer, K. Levin, T. Grimmsmann, N. Perwitz, A. Eirich, H. Beck-Nielsen, and H. H. Klein
Troglitazone Treatment Increases Protein Kinase B Phosphorylation in Skeletal Muscle of Normoglycemic Subjects at Risk for the Development of Type 2 Diabetes
Diabetes, September 1, 2002; 51(9): 2691 - 2697.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-B. Kim, G. I. Shulman, and B. B. Kahn
Fatty Acid Infusion Selectively Impairs Insulin Action on Akt1 and Protein Kinase C lambda /zeta but Not on Glycogen Synthase Kinase-3
J. Biol. Chem., August 30, 2002; 277(36): 32915 - 32922.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
H. Hori, T. Sasaoka, H. Ishihara, T. Wada, S. Murakami, M. Ishiki, and M. Kobayashi
Association of SH2-Containing Inositol Phosphatase 2 With the Insulin Resistance of Diabetic db/db Mice
Diabetes, August 1, 2002; 51(8): 2387 - 2394.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
R. V. Farese
Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states
Am J Physiol Endocrinol Metab, July 1, 2002; 283(1): E1 - E11.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
M. L. Standaert, Y. Kanoh, M. P. Sajan, G. Bandyopadhyay, and R. V. Farese
Cbl, IRS-1, and IRS-2 Mediate Effects of Rosiglitazone on PI3K, PKC-{lambda}, and Glucose Transport in 3T3/L1 Adipocytes
Endocrinology, May 1, 2002; 143(5): 1705 - 1716.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. Letiges, M. Plomann, M. L. Standaert, G. Bandyopadhyay, M. P. Sajan, Y. Kanoh, and R. V. Farese
Knockout of PKC{alpha} Enhances Insulin Signaling Through PI3K
Mol. Endocrinol., April 1, 2002; 16(4): 847 - 858.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
J. Shao, H. Yamashita, L. Qiao, B. Draznin, and J. E. Friedman
Phosphatidylinositol 3-Kinase Redistribution Is Associated With Skeletal Muscle Insulin Resistance in Gestational Diabetes Mellitus
Diabetes, January 1, 2002; 51(1): 19 - 29.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
T. P. Ciaraldi, A. P.S. Kong, N. V. Chu, D. D. Kim, S. Baxi, M. Loviscach, R. Plodkowski, R. Reitz, M. Caulfield, S. Mudaliar, et al.
Regulation of Glucose Transport and Insulin Signaling by Troglitazone or Metformin in Adipose Tissue of Type 2 Diabetic Subjects
Diabetes, January 1, 2002; 51(1): 30 - 36.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Wakino, U. Kintscher, Z. Liu, S. Kim, F. Yin, M. Ohba, T. Kuroki, A. H. Schonthal, W. A. Hsueh, and R. E. Law
Peroxisome Proliferator-activated Receptor gamma Ligands Inhibit Mitogenic Induction of p21Cip1 by Modulating the Protein Kinase Cdelta Pathway in Vascular Smooth Muscle Cells
J. Biol. Chem., December 7, 2001; 276(50): 47650 - 47657.
[Abstract] [Full Text] [PDF]

Home page
 DiabetesHome page
A. L. Hevener, D. Reichart, A. Janez, and J. Olefsky
Thiazolidinedione Treatment Prevents Free Fatty Acid-Induced Insulin Resistance in Male Wistar Rats
Diabetes, October 1, 2001; 50(10): 2316 - 2322.
[Abstract] [Full Text]

Home page
 DiabetesHome page
F. Tremblay, C. Lavigne, H. Jacques, and A. Marette
Defective Insulin-Induced GLUT4 Translocation in Skeletal Muscle of High Fat-Fed Rats Is Associated With Alterations in Both Akt/Protein Kinase B and Atypical Protein Kinase C ({zeta}/{lambda}) Activities
Diabetes, August 1, 2001; 50(8): 1901 - 1910.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
C. J. Lynch, B. J. Patson, S. A. Goodman, D. Trapolsi, and S. R. Kimball
Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR
Am J Physiol Endocrinol Metab, July 1, 2001; 281(1): E25 - E34.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Kanoh, G. Bandyopadhyay, M. P. Sajan, M. L. Standaert, and R. V. Farese
Rosiglitazone, Insulin Treatment, and Fasting Correct Defective Activation of Protein Kinase C-{{zeta}}/{{lambda}} by Insulin in Vastus Lateralis Muscles and Adipocytes of Diabetic Rats
Endocrinology, April 1, 2001; 142(4): 1595 - 1605.
[Abstract] [Full Text]

Home page
 Exp. Biol. Med.Home page
R. V. Farese
Insulin-Sensitive Phospholipid Signaling Systems and Glucose Transport. Update II
Experimental Biology and Medicine, April 1, 2001; 226(4): 283 - 295.
[Abstract] [Full Text]

Home page
 Nucleic Acids ResHome page
L. A. Rafty and L. M. Khachigian
Sp1 phosphorylation regulates inducible expression of platelet-derived growth factor B-chain gene via atypical protein kinase C-{{zeta}}
Nucleic Acids Res., March 1, 2001; 29(5): 1027 - 1033.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.