Advertisement
JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M907962199 on April 4, 2000

J. Biol. Chem., Vol. 275, Issue 24, 18061-18069, June 16, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/24/18061    most recent
M907962199v1
Right arrow Submit a Letter to Editor
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cichy, J.
Right arrow Articles by Puré, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cichy, J.
Right arrow Articles by Puré, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Oncostatin M and Transforming Growth Factor-beta 1 Induce Post-translational Modification and Hyaluronan Binding to CD44 in Lung-derived Epithelial Tumor Cells*

Joanna CichyDagger § and Ellen PuréDagger

From the Dagger  Wistar Institute, Philadelphia, Pennsylvania 19104, the § Institute of Molecular Biology, Jagiellonian University, 31-120 Kraków, Poland, and the  Ludwig Institute for Cancer Research, New York, New York 10158

CD44, a receptor for hyaluronan (HA), has been implicated in tumor growth and metastasis. Most CD44-positive cells fail to exhibit constitutive HA receptor function but CD44-mediated HA binding on hematopoetic cells can be induced by antibody cross-linking of the receptor and by physiologic stimuli, including cytokines. We now demonstrate that oncostatin M (OSM) and transforming growth factor-beta 1, cytokines known to regulate the growth of tumor cells, stimulate HA binding in lung epithelial-derived tumor cells. In lung epithelial-derived tumor cells, cytokine-induced binding resulted from post-translational modification of the receptor. OSM-induced HA binding was associated with a reduction in N-linked carbohydrate content of CD44. In addition, OSM induced HA binding via a novel mechanism requiring sulfation of chondroitin sulfate chains linked to CD44. The mechanism underlying transforming growth factor-beta 1 induced HA binding was distinct from the effects of OSM. The data presented indicate that modulation of the glycosylation and sulfation of CD44 by cytokines provides mechanisms for regulating cell adhesion during tumor growth and metastasis.

* This work was supported by a fellowship from the Cancer Research Institute (to J. C.) and a grant from the Arthritis Foundation (to E. P.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
A. Iwase, R. Shen, D. Navarro, and D. M. Nanus
Direct Binding of Neutral Endopeptidase 24.11 to Ezrin/Radixin/Moesin (ERM) Proteins Competes with the Interaction of CD44 with ERM Proteins
J. Biol. Chem., March 19, 2004; 279(12): 11898 - 11905.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
J. Cichy and E. Pure
The liberation of CD44
J. Cell Biol., June 9, 2003; 161(5): 839 - 843.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Cichy, R. Bals, J. Potempa, A. Mani, and E. Pure
Proteinase-mediated Release of Epithelial Cell-associated CD44. EXTRACELLULAR CD44 COMPLEXES WITH COMPONENTS OF CELLULAR MATRICES
J. Biol. Chem., November 8, 2002; 277(46): 44440 - 44447.
[Abstract] [Full Text] [PDF]

Home page
 GlycobiologyHome page
M. Delcommenne, R. Kannagi, and P. Johnson
TNF-{alpha} increases the carbohydrate sulfation of CD44: induction of 6-sulfo N-acetyl lactosamine on N- and O-linked glycans
Glycobiology, October 1, 2002; 12(10): 613 - 622.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. L. Brown, A. Maiti, and P. Johnson
Role of Sulfation in CD44-Mediated Hyaluronan Binding Induced by Inflammatory Mediators in Human CD14+ Peripheral Blood Monocytes
J. Immunol., November 1, 2001; 167(9): 5367 - 5374.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
T. D. Camenisch and J. A. McDonald
Hyaluronan . Is Bigger Better?
Am. J. Respir. Cell Mol. Biol., October 1, 2000; 23(4): 431 - 433.
[Full Text]

Home page
 J. Biol. Chem.Home page
J. M. Chong and D. W. Speicher
Determination of Disulfide Bond Assignments and N-Glycosylation Sites of the Human Gastrointestinal Carcinoma Antigen GA733-2 (CO17-1A, EGP, KS1-4, KSA, and Ep-CAM)
J. Biol. Chem., February 16, 2001; 276(8): 5804 - 5813.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.
Advertisement
spacer
Advertisement
Advertisement