JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M000040200 on April 6, 2000

J. Biol. Chem., Vol. 275, Issue 24, 18195-18200, June 16, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/24/18195    most recent
M000040200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chan, S. L.
Right arrow Articles by Mattson, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chan, S. L.
Right arrow Articles by Mattson, M. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Presenilin-1 Mutations Increase Levels of Ryanodine Receptors and Calcium Release in PC12 Cells and Cortical Neurons*

Sic L. ChanDagger §, Michael Mayne||, Clark P. Holden||, Jonathan D. Geiger||, and Mark P. MattsonDagger §**

From the Dagger  Sanders-Brown Research Center on Aging, University of Kentucky, Lexington, Kentucky 40536, the § Laboratory of Neurosciences, NIA, National Institutes of Health, Baltimore, Maryland 21224, and the || Department of Pharmacology and Therapeutics, University of Manitoba Faculty of Medicine, Winnipeg, Manitoba, Canada

Many cases of early-onset inherited Alzheimer's disease (AD) are caused by mutations in the presenilin-1 (PS1) gene. PS1 mutations may perturb cellular Ca2+ homeostasis and thereby render neurons vulnerable to excitotoxicity and apoptosis. We now report that PC12 cells expressing PS1 mutations and primary hippocampal neurons from PS1 mutant knockin mice exhibit greatly increased levels of ryanodine receptors (RyR) and enhanced Ca2+ release following stimulation with caffeine. Double-labeling immunostaining and co-immunoprecipitation analyses indicate that PS1 and RyR are colocalized and interact physically. Caffeine treatment sensitizes neurons expressing mutant PS1 to apoptosis induced by amyloid beta -peptide, a neurotic peptide linked to the pathogenesis of AD. When taken together with recent evidence for alterations in RyR in brains of AD patients, our data suggest that PS1 mutations may promote neuronal degeneration in AD by increasing transcription and translation of RyR and altering functional properties of ryanodine-sensitive Ca2+ pools.

* This work was supported by National Institutes of Health NIA Grant PO1AG10836.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

These authors contributed equally to this work.

** To whom all correspondence should be addressed: Laboratory of Neurosciences, GRC 4F01, NIA, National Institutes of Health, 5600 Nathan Shock Dr., Baltimore, MD 21224. Tel.: 410-558-8462; Fax: 410-558-8465; E-mail: mattsonm@grc.nia.nih.gov.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
V. Dror, T. B. Kalynyak, Y. Bychkivska, M. H. Z. Frey, M. Tee, K. D. Jeffrey, V. Nguyen, D. S. Luciani, and J. D. Johnson
Glucose and Endoplasmic Reticulum Calcium Channels Regulate HIF-1{beta} via Presenilin in Pancreatic {beta}-Cells
J. Biol. Chem., April 11, 2008; 283(15): 9909 - 9916.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
K. De Keersmaecker, I. Lahortiga, N. Mentens, C. Folens, L. Van Neste, S. Bekaert, P. Vandenberghe, M. D. Odero, P. Marynen, and J. Cools
In vitro validation of {gamma}-secretase inhibitors alone or in combination with other anti-cancer drugs for the treatment of T-cell acute lymphoblastic leukemia
Haematologica, April 1, 2008; 93(4): 533 - 542.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
G. Liang, Q. Wang, Y. Li, B. Kang, M. F. Eckenhoff, R. G. Eckenhoff, and H. Wei
A Presenilin-1 Mutation Renders Neurons Vulnerable to Isoflurane Toxicity
Anesth. Analg., February 1, 2008; 106(2): 492 - 500.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
G. E. Stutzmann
The Pathogenesis of Alzheimers Disease Is It a Lifelong "Calciumopathy"?
Neuroscientist, October 1, 2007; 13(5): 546 - 559.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. Bull, J. P. Finkelstein, A. Humeres, M. I. Behrens, and C. Hidalgo
Effects of ATP, Mg2+, and redox agents on the Ca2+ dependence of RyR channels from rat brain cortex
Am J Physiol Cell Physiol, July 1, 2007; 293(1): C162 - C171.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
G. E STUTZMANN, I. SMITH, A. CACCAMO, S. ODDO, I. PARKER, and F. LAFERLA
Enhanced Ryanodine-Mediated Calcium Release in Mutant PS1-Expressing Alzheimer's Mouse Models
Ann. N.Y. Acad. Sci., February 1, 2007; 1097(1): 265 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. S Parihar and G. J. Brewer
Mitoenergetic failure in Alzheimer disease
Am J Physiol Cell Physiol, January 1, 2007; 292(1): C8 - C23.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Supnet, J. Grant, H. Kong, D. Westaway, and M. Mayne
Amyloid-beta-(1-42) Increases Ryanodine Receptor-3 Expression and Function in Neurons of TgCRND8 Mice
J. Biol. Chem., December 15, 2006; 281(50): 38440 - 38447.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
G. E. Stutzmann, I. Smith, A. Caccamo, S. Oddo, F. M. LaFerla, and I. Parker
Enhanced ryanodine receptor recruitment contributes to Ca2+ disruptions in young, adult, and aged Alzheimer's disease mice.
J. Neurosci., May 10, 2006; 26(19): 5180 - 5189.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Camandola, R. G. Cutler, D. S. Gary, O. Milhavet, and M. P. Mattson
Suppression of Calcium Release from Inositol 1,4,5-Trisphosphate-sensitive Stores Mediates the Anti-apoptotic Function of Nuclear Factor-{kappa}B
J. Biol. Chem., June 10, 2005; 280(23): 22287 - 22296.
[Abstract] [Full Text] [PDF]

Home page
 NeuroscientistHome page
G. E. Stutzmann
Calcium Dysregulation, IP3 Signaling, and Alzheimer's Disease
Neuroscientist, April 1, 2005; 11(2): 110 - 115.
[Abstract] [PDF]

Home page
 Physiol. Rev.Home page
A. Verkhratsky
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Physiol Rev, January 1, 2005; 85(1): 201 - 279.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. A. Christensen, A. Shtifman, P. D. Allen, J. R. Lopez, and H. W. Querfurth
Calcium Dyshomeostasis in {beta}-Amyloid and Tau-bearing Skeletal Myotubes
J. Biol. Chem., December 17, 2004; 279(51): 53524 - 53532.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. L. Chan, W. Fu, P. Zhang, A. Cheng, J. Lee, K. Kokame, and M. P. Mattson
Herp Stabilizes Neuronal Ca2+ Homeostasis and Mitochondrial Function during Endoplasmic Reticulum Stress
J. Biol. Chem., July 2, 2004; 279(27): 28733 - 28743.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. O. Popescu, A. Cedazo-Minguez, E. Benedikz, T. Nishimura, B. Winblad, M. Ankarcrona, and R. F. Cowburn
{gamma}-Secretase Activity of Presenilin 1 Regulates Acetylcholine Muscarinic Receptor-mediated Signal Transduction
J. Biol. Chem., February 20, 2004; 279(8): 6455 - 6464.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-C. Suen, M.-S. Yu, K.-F. So, R. C.-C. Chang, and J. Hugon
Upstream Signaling Pathways Leading to the Activation of Double-stranded RNA-dependent Serine/Threonine Protein Kinase in {beta}-Amyloid Peptide Neurotoxicity
J. Biol. Chem., December 12, 2003; 278(50): 49819 - 49827.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. H. George, G. V. Higgs, J. J. Mackrill, and F. A. Lai
Dysregulated Ryanodine Receptors Mediate Cellular Toxicity: RESTORATION OF NORMAL PHENOTYPE BY FKBP12.6
J. Biol. Chem., August 1, 2003; 278(31): 28856 - 28864.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Cedazo-Minguez, B. O. Popescu, M. Ankarcrona, T. Nishimura, and R. F. Cowburn
The Presenilin 1 Delta E9 Mutation Gives Enhanced Basal Phospholipase C Activity and a Resultant Increase in Intracellular Calcium Concentrations
J. Biol. Chem., September 20, 2002; 277(39): 36646 - 36655.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. P. Mattson, S. L. Chan, and W. Duan
Modification of Brain Aging and Neurodegenerative Disorders by Genes, Diet, and Behavior
Physiol Rev, July 1, 2002; 82(3): 637 - 672.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Lu, S. L. Chan, W. Fu, and M. P. Mattson
The Lipid Peroxidation Product 4-Hydroxynonenal Facilitates Opening of Voltage-dependent Ca2+ Channels in Neurons by Increasing Protein Tyrosine Phosphorylation
J. Biol. Chem., June 28, 2002; 277(27): 24368 - 24375.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
J. P. BLASS
The Mitochondrial Spiral: An Adequate Cause of Dementia in the Alzheimer's Syndrome
Ann. N.Y. Acad. Sci., December 1, 2000; 924(1): 170 - 183.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Schneider, D. Reverse, I. Dewachter, L. Ris, N. Caluwaerts, C. Kuiperi, M. Gilis, H. Geerts, H. Kretzschmar, E. Godaux, et al.
Mutant Presenilins Disturb Neuronal Calcium Homeostasis in the Brain of Transgenic Mice, Decreasing the Threshold for Excitotoxicity and Facilitating Long-term Potentiation
J. Biol. Chem., April 6, 2001; 276(15): 11539 - 11544.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. W. Glazner, S. Camandola, J. D. Geiger, and M. P. Mattson
Endoplasmic Reticulum D-myo-Inositol 1,4,5-Trisphosphate-sensitive Stores Regulate Nuclear Factor-kappa B Binding Activity in a Calcium-independent Manner
J. Biol. Chem., June 15, 2001; 276(25): 22461 - 22467.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Siman, D. G. Flood, G. Thinakaran, and R. W. Neumar
Endoplasmic Reticulum Stress-induced Cysteine Protease Activation in Cortical Neurons. EFFECT OF AN ALZHEIMER'S DISEASE-LINKED PRESENILIN-1 KNOCK-IN MUTATION
J. Biol. Chem., November 21, 2001; 276(48): 44736 - 44743.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.