| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 275, Issue 26, 19906-19912, June 30, 2000
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the We have isolated and characterized a novel
iron-regulated gene that is homologous to the divalent metal
transporter 1 family of metal transporters. This gene, termed metal
transporter protein (mtp1), is expressed in tissues
involved in body iron homeostasis including the developing and mature
reticuloendothelial system, the duodenum, and the pregnant uterus. MTP1
is also expressed in muscle and central nervous system cells in the
embryo. At the subcellular level, MTP1 is localized to the basolateral
membrane of the duodenal epithelial cell and a cytoplasmic compartment of reticuloendothelial system cells. Overexpression of MTP1 in tissue
culture cells results in intracellular iron depletion. In the adult
mouse, MTP1 expression in the liver and duodenum are reciprocally
regulated. Iron deficiency induces MTP1 expression in the duodenum but
down-regulates expression in the liver. These data indicate that MTP1
is an iron-regulated membrane-spanning protein that is involved in
intracellular iron metabolism.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF215636, AF215637, and AF216834.
A Novel Mammalian Iron-regulated Protein Involved in
Intracellular Iron Metabolism*
and
Department of Pathology and the
§ Department of Medicine, University of Texas Health Science
Center, San Antonio, Texas 78229 and the Audie Murphy Veterans
Affairs Hospital, South Texas Veterans Health System,
San Antonio, Texas 78284
*
This work was supported by a grant from the American Heart
Association, Texas Affiliate, and Howard Hughes Medical Institute Pilot
Project Grant, and National Institutes of Health R01DK53079 and
R03DK96009.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed. Tel.:
210-567-4848; Fax: 210-567-1956; E-mail:
Haile@UTHSCSA.edu.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  K. E. Van Zandt, F. B. Sow, W. C. Florence, B. S. Zwilling, A. R. Satoskar, L. S. Schlesinger, and W. P. Lafuse The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome J. Leukoc. Biol., September 1, 2008; 84(3): 689 - 700. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E.-Y. Kim, S.-K. Ham, M. K. Shigenaga, and O. Han Bioactive Dietary Polyphenolic Compounds Reduce Nonheme Iron Transport across Human Intestinal Cell Monolayers J. Nutr., September 1, 2008; 138(9): 1647 - 1651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N. Paradkar, I. De Domenico, N. Durchfort, I. Zohn, J. Kaplan, and D. M. Ward Iron depletion limits intracellular bacterial growth in macrophages Blood, August 1, 2008; 112(3): 866 - 874. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. C. Andrews Forging a field: the golden age of iron biology Blood, July 15, 2008; 112(2): 219 - 230. [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Hamada, T.-N. Kono, Y. Moriguchi, M. Higuchi, and M. Fukagawa Alteration of mRNA expression of molecules related to iron metabolism in adenine-induced renal failure rats: a possible mechanism of iron deficiency in chronic kidney disease patients on treatment Nephrol. Dial. Transplant., June 1, 2008; 23(6): 1886 - 1891. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Aigner, I. Theurl, M. Theurl, D. Lederer, H. Haufe, O. Dietze, M. Strasser, C. Datz, and G. Weiss Pathways underlying iron accumulation in human nonalcoholic fatty liver disease Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1374 - 1383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. D. San Martin, C. Garri, F. Pizarro, T. Walter, E. C. Theil, and M. T. Nunez Caco-2 Intestinal Epithelial Cells Absorb Soybean Ferritin by {micro}2 (AP2)-Dependent Endocytosis J. Nutr., April 1, 2008; 138(4): 659 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. F. Collins, Z. Hu, P. N. Ranganathan, D. Feng, L. M. Garrick, M. D. Garrick, and R. W. Browne Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators Am J Physiol Gastrointest Liver Physiol, April 1, 2008; 294(4): G948 - G962. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T Chaston, B Chung, M Mascarenhas, J Marks, B Patel, S K Srai, and P Sharp Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells Gut, March 1, 2008; 57(3): 374 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Theurl, M. Theurl, M. Seifert, S. Mair, M. Nairz, H. Rumpold, H. Zoller, R. Bellmann-Weiler, H. Niederegger, H. Talasz, et al. Autocrine formation of hepcidin induces iron retention in human monocytes Blood, February 15, 2008; 111(4): 2392 - 2399. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Boult, K. Roberts, M. J. Brookes, S. Hughes, J. P. Bury, S. S. Cross, G. J. Anderson, R. Spychal, T. Iqbal, and C. Tselepis Overexpression of Cellular Iron Import Proteins Is Associated with Malignant Progression of Esophageal Adenocarcinoma Clin. Cancer Res., January 15, 2008; 14(2): 379 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. Allen, J. A. del Campo, J. Kropat, and S. S. Merchant FEA1, FEA2, and FRE1, Encoding Two Homologous Secreted Proteins and a Candidate Ferrireductase, Are Expressed Coordinately with FOX1 and FTR1 in Iron-Deficient Chlamydomonas reinhardtii Eukaryot. Cell, October 1, 2007; 6(10): 1841 - 1852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Frazer, S. J. Wilkins, and G. J. Anderson Elevated iron absorption in the neonatal rat reflects high expression of iron transport genes in the distal alimentary tract Am J Physiol Gastrointest Liver Physiol, September 1, 2007; 293(3): G525 - G531. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Wang, X. Di, R. B. D'Agostino Jr., S. V. Torti, and F. M. Torti Excess Capacity of the Iron Regulatory Protein System J. Biol. Chem., August 24, 2007; 282(34): 24650 - 24659. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Piccinelli and T. Samuelsson Evolution of the iron-responsive element RNA, July 1, 2007; 13(7): 952 - 966. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. De Domenico, D. M. Ward, C. Langelier, M. B. Vaughn, E. Nemeth, W. I. Sundquist, T. Ganz, G. Musci, and J. Kaplan The Molecular Mechanism of Hepcidin-mediated Ferroportin Down-Regulation Mol. Biol. Cell, July 1, 2007; 18(7): 2569 - 2578. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Gardenghi, M. F. Marongiu, P. Ramos, E. Guy, L. Breda, A. Chadburn, Y. Liu, N. Amariglio, G. Rechavi, E. A. Rachmilewitz, et al. Ineffective erythropoiesis in -thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin Blood, June 1, 2007; 109(11): 5027 - 5035. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Robach, G. Cairo, C. Gelfi, F. Bernuzzi, H. Pilegaard, A. Vigano, P. Santambrogio, P. Cerretelli, J. A. L. Calbet, S. Moutereau, et al. Strong iron demand during hypoxia-induced erythropoiesis is associated with down-regulation of iron-related proteins and myoglobin in human skeletal muscle Blood, June 1, 2007; 109(11): 4724 - 4731. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. E. Zohn, I. De Domenico, A. Pollock, D. M. Ward, J. F. Goodman, X. Liang, A. J. Sanchez, L. Niswander, and J. Kaplan The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease Blood, May 15, 2007; 109(10): 4174 - 4180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. FARAG, R. J. STOLTZFUS, S. S. KHALFAN, and J. M. TIELSCH HELICOBACTER PYLORI INFECTION IS ASSOCIATED WITH SEVERE ANEMIA OF PREGNANCY ON PEMBA ISLAND, ZANZIBAR Am J Trop Med Hyg, March 1, 2007; 76(3): 541 - 548. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Markel, P. R. Crisostomo, M. Wang, C. M. Herring, K. K. Meldrum, K. D. Lillemoe, and D. R. Meldrum The struggle for iron: gastrointestinal microbes modulate the host immune response during infection J. Leukoc. Biol., February 1, 2007; 81(2): 393 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ganz Molecular Control of Iron Transport J. Am. Soc. Nephrol., February 1, 2007; 18(2): 394 - 400. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Rodriguez, P. Pan, and S. Parkkila Expression Studies of Neogenin and Its Ligand Hemojuvelin in Mouse Tissues J. Histochem. Cytochem., January 1, 2007; 55(1): 85 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. I. Haurani Hepcidin and the anemia of chronic disease. Ann. Clin. Lab. Sci., December 1, 2006; 36(1): 3 - 6. [Full Text] [PDF]
|
|
|
|
|
|
M. Pak, M. A. Lopez, V. Gabayan, T. Ganz, and S. Rivera Suppression of hepcidin during anemia requires erythropoietic activity Blood, December 1, 2006; 108(12): 3730 - 3735. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Yoon, Y. D. Pastore, V. Divoky, E. Liu, A. E. Mlodnicka, K. Rainey, P. Ponka, G. L. Semenza, A. Schumacher, and J. T. Prchal Hypoxia-inducible Factor-1 Deficiency Results in Dysregulated Erythropoiesis Signaling and Iron Homeostasis in Mouse Development J. Biol. Chem., September 1, 2006; 281(35): 25703 - 25711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N.-B. Nguyen, K. D. Callaghan, A. J. Ghio, D. J. Haile, and F. Yang Hepcidin expression and iron transport in alveolar macrophages Am J Physiol Lung Cell Mol Physiol, September 1, 2006; 291(3): L417 - L425. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Constante, W. Jiang, D. Wang, V.-A. Raymond, M. Bilodeau, and M. M. Santos Distinct requirements for Hfe in basal and induced hepcidin levels in iron overload and inflammation Am J Physiol Gastrointest Liver Physiol, August 1, 2006; 291(2): G229 - G237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. W. Swinkels, M. C.H. Janssen, J. Bergmans, and J. J.M. Marx Hereditary Hemochromatosis: Genetic Complexity and New Diagnostic Approaches Clin. Chem., June 1, 2006; 52(6): 950 - 968. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Abouhamed, J. Gburek, W. Liu, B. Torchalski, A. Wilhelm, N. A. Wolff, E. I. Christensen, F. Thevenod, and C. P. Smith Divalent metal transporter 1 in the kidney proximal tubule is expressed in late endosomes/lysosomal membranes: implications for renal handling of protein-metal complexes Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1525 - F1533. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Chlosta, D. S. Fishman, L. Harrington, E. E. Johnson, M. D. Knutson, M. Wessling-Resnick, and B. J. Cherayil The Iron Efflux Protein Ferroportin Regulates the Intracellular Growth of Salmonella enterica. Infect. Immun., May 1, 2006; 74(5): 3065 - 3067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Chen, G. Huang, T. Su, H. Gao, Z. K. Attieh, A. T. McKie, G. J. Anderson, and C. D. Vulpe Decreased Hephaestin Activity in the Intestine of Copper-Deficient Mice Causes Systemic Iron Deficiency J. Nutr., May 1, 2006; 136(5): 1236 - 1241. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Donovan, C. N. Roy, and N. C. Andrews The Ins and Outs of Iron Homeostasis Physiology, April 1, 2006; 21(2): 115 - 123. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mok, A. E. Mlodnicka, M. W. Hentze, M. Muckenthaler, and A. Schumacher The Molecular Circuitry Regulating the Switch between Iron Deficiency and Overload in Mice J. Biol. Chem., March 24, 2006; 281(12): 7946 - 7951. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Z. Chang, Y. Ke, J.-R. Du, G. M. Halpern, K.-P. Ho, L. Zhu, X.-S. Gu, Y.-J. Xu, Q. Wang, L.-Z. Li, et al. Increased Divalent Metal Transporter 1 Expression Might Be Associated with the Neurotoxicity of L-DOPA Mol. Pharmacol., March 1, 2006; 69(3): 968 - 974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Moriya and M. C. Linder Vesicular transport and apotransferrin in intestinal iron absorption, as shown in the Caco-2 cell model Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G301 - G309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wessling-Resnick Iron Imports. III. Transfer of iron from the mucosa into circulation Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G1 - G6. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Canonne-Hergaux, A. Donovan, C. Delaby, H.-j. Wang, and P. Gros Comparative studies of duodenal and macrophage ferroportin proteins Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G156 - G163. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. S. Kalinowski and D. R. Richardson The Evolution of Iron Chelators for the Treatment of Iron Overload Disease and Cancer Pharmacol. Rev., December 1, 2005; 57(4): 547 - 583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nanami, T. Ookawara, Y. Otaki, K. Ito, R. Moriguchi, K. Miyagawa, Y. Hasuike, M. Izumi, H. Eguchi, K. Suzuki, et al. Tumor Necrosis Factor-{alpha}-Induced Iron Sequestration and Oxidative Stress in Human Endothelial Cells Arterioscler. Thromb. Vasc. Biol., December 1, 2005; 25(12): 2495 - 2501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Camaschella Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders Blood, December 1, 2005; 106(12): 3710 - 3717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Delaby, N. Pilard, A. S. Goncalves, C. Beaumont, and F. Canonne-Hergaux Presence of the iron exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and down-regulated by hepcidin Blood, December 1, 2005; 106(12): 3979 - 3984. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Kasvosve, Z. A. Gomo, K. J Nathoo, P. Matibe, B. Mudenge, M. Loyevsky, and V. R Gordeuk Effect of ferroportin Q248H polymorphism on iron status in African children Am. J. Clinical Nutrition, November 1, 2005; 82(5): 1102 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Ravia, R. M. Stephen, F. K. Ghishan, and J. F. Collins Menkes Copper ATPase (Atp7a) Is a Novel Metal-responsive Gene in Rat Duodenum, and Immunoreactive Protein Is Present on Brush-border and Basolateral Membrane Domains J. Biol. Chem., October 28, 2005; 280(43): 36221 - 36227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Galy, D. Ferring, B. Minana, O. Bell, H. G. Janser, M. Muckenthaler, K. Schumann, and M. W. Hentze Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2) Blood, October 1, 2005; 106(7): 2580 - 2589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Rivera, E. Nemeth, V. Gabayan, M. A. Lopez, D. Farshidi, and T. Ganz Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs Blood, September 15, 2005; 106(6): 2196 - 2199. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. K Roughead, C. A Zito, and J. R Hunt Inhibitory effects of dietary calcium on the initial uptake and subsequent retention of heme and nonheme iron in humans: comparisons using an intestinal lavage method Am. J. Clinical Nutrition, September 1, 2005; 82(3): 589 - 597. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. S. Cooperman, E. G. Meyron-Holtz, H. Olivierre-Wilson, M. C. Ghosh, J. P. McConnell, and T. A. Rouault Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2 Blood, August 1, 2005; 106(3): 1084 - 1091. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Drakesmith, L. M. Schimanski, E. Ormerod, A. T. Merryweather-Clarke, V. Viprakasit, J. P. Edwards, E. Sweetland, J. M. Bastin, D. Cowley, Y. Chinthammitr, et al. Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin Blood, August 1, 2005; 106(3): 1092 - 1097. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Yang, D. J. Haile, X. Wang, L. A. Dailey, J. G. Stonehuerner, and A. J. Ghio Apical location of ferroportin 1 in airway epithelia and its role in iron detoxification in the lung Am J Physiol Lung Cell Mol Physiol, July 1, 2005; 289(1): L14 - L23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. De Domenico, D. M. Ward, E. Nemeth, M. B. Vaughn, G. Musci, T. Ganz, and J. Kaplan The molecular basis of ferroportin-linked hemochromatosis PNAS, June 21, 2005; 102(25): 8955 - 8960. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Viatte, J.-C. Lesbordes-Brion, D.-Q. Lou, M. Bennoun, G. Nicolas, A. Kahn, F. Canonne-Hergaux, and S. Vaulont Deregulation of proteins involved in iron metabolism in hepcidin-deficient mice Blood, June 15, 2005; 105(12): 4861 - 4864. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. M. Schimanski, H. Drakesmith, A. T. Merryweather-Clarke, V. Viprakasit, J. P. Edwards, E. Sweetland, J. M. Bastin, D. Cowley, Y. Chinthammitr, K. J. H. Robson, et al. In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations Blood, May 15, 2005; 105(10): 4096 - 4102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. F. Collins, C. A. Franck, K. V. Kowdley, and F. K. Ghishan Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum Am J Physiol Gastrointest Liver Physiol, May 1, 2005; 288(5): G964 - G971. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
