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J. Biol. Chem., Vol. 275, Issue 27, 20450-20457, July 7, 2000
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§¶,
,
,
,
§**, and
From the The role of phosphoinositide signaling in
olfactory transduction is still being resolved. Compelling functional
evidence for the transduction of odor signals via phosphoinositide
pathways in olfactory transduction comes from invertebrate olfactory
systems, in particular lobster olfactory receptor neurons. We now
provide molecular evidence for two components of the phosphoinositide signaling pathway in lobster olfactory receptor neurons, a G protein
Whitney Laboratory, University of Florida,
St. Augustine, Florida 32086, and the Departments of
§ Neuroscience,
Microbiology and Cell Science, and
** Zoology, University of Florida, Gainesville, Florida 32610
subunit of the Gq family and an inositol
1,4,5-trisphosphate-gated channel or an inositol 1,4,5-trisphosphate
(IP3) receptor. Both proteins localize to the site of
olfactory transduction, the outer dendrite of the olfactory receptor
neurons. Furthermore, the IP3 receptor localizes to
membranes in the ciliary transduction compartment of these cells at
both the light microscopic and electron microscopic levels. Given the
absence of intracellular organelles in the sub-micron diameter
olfactory cilia, this finding indicates that the IP3 receptor is associated with the plasma membrane and provides the first
definitive evidence for plasma membrane localization of an
IP3R in neurons. The association of the IP3
receptor with the plasma membrane may be a novel mechanism for
regulating intracellular cations in restricted cellular compartments of neurons.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AAC61691 and AF201328.
¶ To whom correspondence should be addressed: Dept. Anatomy and Neurobiology, University of Maryland School of Medicine, Health Sciences Facility, Rm. 232, 685 W. Baltimore St., Baltimore, MD 21201. Tel.: 410-706-5851; Fax: 410-706-2512; E-mail: smunger@mail.com.This article has been cited by other articles:
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