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J. Biol. Chem., Vol. 275, Issue 29, 21793-21796, July 21, 2000
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From the Dana-Farber Cancer Institute, Harvard Medical School,
Boston, Massachusetts 02115 and the Apoptosis is induced by the release of cytochrome
c from mitochondria to the cytoplasm. The present studies
demonstrate that the phorbol ester
12-O-tetradecanoylphorbol-13-acetate (TPA) induces translocation of protein kinase C (PKC)
ACCELERATED PUBLICATION
Mitochondrial Translocation of Protein Kinase C 
in Phorbol
Ester-induced Cytochrome c Release and Apoptosis*
,, Lovelace Respiratory
Research Institute, Albuquerque, New Mexico 87115
from the cytoplasm to mitochondria. The results also show that translocation of PKC results in release of cytochrome c. The functional
significance of this event is further supported by the demonstration
that PKC translocation is required for TPA-induced apoptosis. These
findings demonstrate that translocation of PKC to mitochondria is
responsible, at least in part, for inducing cytochrome c
release and apoptosis.
*
This work was supported by Public Health Service Grants
CA42802 (to D. K.) and GM58200 (to R. D.) awarded by the NCI,
DHHS and by Charlotte Geyer Foundation Grant 9219401 (to S. K.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
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