| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 275, Issue 29, 21883-21888, July 21, 2000
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the
-Catenin Inhibits 
-Catenin Signaling by Preventing
Formation of a -Catenin·T-cell Factor·DNA Complex*
,¶
Medical Research Council Laboratory for
Molecular Cell Biology, University College London, London WC1E 6BT and
the § Breakthrough Toby Robins Breast Cancer Research
Centre, Institute of Cancer Research, London, SW3
6JB, United Kingdom
-Catenin and 
-catenin link cadherins to the
cytoskeleton at adherens junctions. -Catenin also associates with
members of the T-cell factor (Tcf) family of transcription factors, and
mutations in -catenin lead to activation of
Tcf-dependent transcription and increased cell growth.
Although the loss of -catenin expression can also promote cell
growth, the role of endogenous -catenin in -catenin signaling is
unclear. Here we show that loss of -catenin expression in a colon
cancer cell line correlates with increased Tcf-dependent
transcription. The presence of -catenin in colon cancer cell nuclei
suggests that it inhibits transcription directly, and, in agreement
with this, ectopic expression of -catenin in the nucleus represses
Tcf-dependent transcription. Furthermore, recombinant
-catenin disrupts the interaction between the -catenin·Tcf complex and DNA. We conclude that -catenin inhibits -catenin signaling in the nucleus by interfering with the formation of a
-catenin·Tcf·DNA complex.
*
This work was supported in part by a Career Development
Fellowship from the Wellcome Trust (to R. K.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  W.-H. Lien, O. Klezovitch, M. Null, and V. Vasioukhin {alpha}E-catenin is not a significant regulator of {beta}-catenin signaling in the developing mammalian brain J. Cell Sci., May 1, 2008; 121(9): 1357 - 1362. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Shibata, H. Takano, M. Ito, H. Shioya, M. Hirota, H. Matsumoto, Y. Kakudo, C. Ishioka, T. Akiyama, Y. Kanegae, et al. {alpha}-Catenin is essential in intestinal adenoma formation PNAS, November 13, 2007; 104(46): 18199 - 18204. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Chen, H.-X. Yan, J. Chen, W. Yang, Q. Liu, B. Zhai, H.-F. Cao, S.-Q. Liu, M.-C. Wu, and H.-Y. Wang Negative Regulation of c-Myc Transcription by Pancreas Duodenum Homeobox-1 Endocrinology, May 1, 2007; 148(5): 2168 - 2180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Scott and A. S. Yap Cinderella no longer: {alpha}-catenin steps out of cadherin's shadow J. Cell Sci., November 15, 2006; 119(22): 4599 - 4605. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Willert and K. A. Jones Wnt signaling: is the party in the nucleus? Genes & Dev., June 1, 2006; 20(11): 1394 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S.-G. Hwang, S.-S. Yu, J.-H. Ryu, H.-B. Jeon, Y.-J. Yoo, S.-H. Eom, and J.-S. Chun Regulation of {beta}-Catenin Signaling and Maintenance of Chondrocyte Differentiation by Ubiquitin-independent Proteasomal Degradation of {alpha}-Catenin J. Biol. Chem., April 1, 2005; 280(13): 12758 - 12765. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Zhu, M. Mazor, Y. Kawano, M. M. Walker, H. Y. Leung, K. Armstrong, J. Waxman, and R. M. Kypta Analysis of Wnt Gene Expression in Prostate Cancer: Mutual Inhibition by WNT11 and the Androgen Receptor Cancer Res., November 1, 2004; 64(21): 7918 - 7926. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Gottardi and B. M. Gumbiner Distinct molecular forms of {beta}-catenin are targeted to adhesive or transcriptional complexes J. Cell Biol., October 25, 2004; 167(2): 339 - 349. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. H. Brembeck, T. Schwarz-Romond, J. Bakkers, S. Wilhelm, M. Hammerschmidt, and W. Birchmeier Essential role of BCL9-2 in the switch between {beta}-catenin's adhesive and transcriptional functions Genes & Dev., September 15, 2004; 18(18): 2225 - 2230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D. Merdek, N. T. Nguyen, and D. Toksoz Distinct Activities of the {alpha}-Catenin Family, {alpha}-Catulin and {alpha}-Catenin, on {beta}-Catenin-Mediated Signaling Mol. Cell. Biol., March 15, 2004; 24(6): 2410 - 2422. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Piedra, S. Miravet, J. Castano, H. G. Palmer, N. Heisterkamp, A. Garcia de Herreros, and M. Dunach p120 Catenin-Associated Fer and Fyn Tyrosine Kinases Regulate {beta}-Catenin Tyr-142 Phosphorylation and {beta}-Catenin-{alpha}-Catenin Interaction Mol. Cell. Biol., April 1, 2003; 23(7): 2287 - 2297. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Mareel and A. Leroy Clinical, Cellular, and Molecular Aspects of Cancer Invasion Physiol Rev, April 1, 2003; 83(2): 337 - 376. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Chung, S.-G. Hwang, P. Nguyen, S. Lee, J.-S. Kim, J. W. Kim, P. A. Henkart, D. P. Bottaro, L. Soon, P. Bonvini, et al. Regulation of leukemic cell adhesion, proliferation, and survival by beta -catenin Blood, July 18, 2002; 100(3): 982 - 990. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. C. S. Wong and M. Pignatelli {beta}-Catenin--A Linchpin in Colorectal Carcinogenesis? Am. J. Pathol., February 1, 2002; 160(2): 389 - 401. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
