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Originally published In Press as doi:10.1074/jbc.C000207200 on June 2, 2000

J. Biol. Chem., Vol. 275, Issue 30, 22619-22622, July 28, 2000
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ACCELERATED PUBLICATION
Mitochondria Localization and Dimerization Are Required for CIDE-B to Induce Apoptosis*

Zhengming Chen, Ke Guo, Shen Yon Toh, Zhihong Zhou, and Peng LiDagger

From the Laboratory of Apoptosis Regulation, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore

Cell death-inducing DFF45-like effector (CIDE)-B is a member of the novel family of apoptosis-inducing factors that share homology with the N-terminal region of DFF, the DNA fragmentation factor. The molecular mechanism of CIDE-B-induced apoptosis is unclear. We have shown here that CIDE-B protein is localized in mitochondria and forms homodimers and heterodimers with other family members. Serial deletion analyses suggest that the mitochondria localization signal and dimerization interface are overlapped and localized to the 30 amino acid residues at the C-terminal region of CIDE-B. Mitochondria localization and dimerization are both required for CIDE-B-induced apoptosis. Our study has thus revealed a mechanism for CIDE-B-induced apoptosis by localization to mitochondria and the formation of a high affinity homo- or heterodimeric complex.

* This research was funded by the National Science and Technology Board of Singapore.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed. Tel.: 65-874-3375; Fax: 65-779-1117; E-mail: mcblip@imcb.nus.edu.sg.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
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