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J. Biol. Chem., Vol. 275, Issue 30, 22627-22630, July 28, 2000
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ACCELERATED PUBLICATION
Reprimo, a New Candidate Mediator of the p53-mediated Cell Cycle Arrest at the G2 Phase*

Rieko OhkiDagger §, Jiro NemotoDagger , Hideki MurasawaDagger , Eri OdaDagger , Johji Inazawa, Nobuyuki TanakaDagger , and Tadatsugu TaniguchiDagger ||

From the Dagger  Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan and the  Department of Molecular Cytogenetics, Division of Genetics, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan

A novel gene, Reprimo, in which induction in cells exposed to X-irradiation is dependent on p53 expression, has been isolated. Ectopic p53 expression results in the induction of its mRNA. Reprimo is a highly glycosylated protein and, when ectopically expressed, it is localized in the cytoplasm and induces G2 arrest of the cell cycle. In the arrested cells, both Cdc2 activity and nuclear translocation of cyclin B1 are inhibited, suggesting the involvement of Reprimo in the Cdc2·cyclin B1 regulation pathway. Thus, Reprimo may be a new member involved in the regulation of p53-dependent G2 arrest of the cell cycle.

* This work was supported in part by the Research for the Future Program (Grant 96L00307) and by the Japan Society for the Promotion of Science.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ A Japan Society for the Promotion of Science research associate.

|| To whom correspondence should be addressed. Tel.: 81-3-5800-3220; Fax: 81-3-5841-3450; E-mail: tada@m.u-tokyo.ac.jp.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
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