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J. Biol. Chem., Vol. 275, Issue 31, 24089-24095, August 4, 2000
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From the Zentrum für Molekulare Neurobiologie Hamburg,
Hamburg University, Martinistrasse 85, D-20246 Hamburg, Germany
KCNQ2 and KCNQ3, both of which are mutated in a
type of human neonatal epilepsy, form heteromeric potassium channels
that are expressed in broad regions of the brain. The associated
current may be identical to the M-current, an important regulator of
neuronal excitability. We now show that the RNA encoding the novel
KCNQ5 channel is also expressed in brain and in sympathetic ganglia where it overlaps largely with KCNQ2 and KCNQ3. In addition, it is
expressed in skeletal muscle. KCNQ5 yields currents that activate slowly with depolarization and can form heteromeric channels with KCNQ3. Currents expressed from KCNQ5 have voltage dependences and
inhibitor sensitivities in common with M-currents. They are also
inhibited by M1 muscarinic receptor activation. A KCNQ5 splice variant
found in skeletal muscle displays altered gating kinetics. This
indicates a molecular diversity of channels yielding M-type currents
and suggests a role for KCNQ5 in the regulation of neuronal excitability.
The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF202977.
KCNQ5, a Novel Potassium Channel Broadly Expressed in Brain,
Mediates M-type Currents*
, and
*
This work was supported by grants from the Deutsche
Forschungsgemeinschaft and the Fonds der Chemischen Industrie.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Present address: Institut für Humangenetik,
Universität Bonn, Wilhelmstrasse 31, D-53111 Bonn, Germany.
§
To whom correspondence should be addressed. Tel.:
49-40-42803-4741; Fax: 49-40-42803-4839; E-mail:
Jentsch@plexus.uke.uni- hamburg.de.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
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