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J. Biol. Chem., Vol. 275, Issue 35, 27172-27176, September 1, 2000
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From the Department of Psychology, McGill University,
Montreal, QC H3A 1B1 Canada
Dynein and kinesin are the main
microtubule-dependent motors that mediate intracellular
movement in eukaryotic organisms. We have cloned a full-length cDNA
encoding rat dynein light chain protein,
robl/LC7-like (class 1), from visual cortex. We
found that rat robl/LC7-like gene is highly
expressed in neocortex and displays the unusual feature of being
rapidly down-regulated by sensory stimulation. This effect was seen at
both mRNA and protein levels in visual cortex, being detectable in
as little as 45 min after the onset of visual stimulation.
Down-regulation by sensory stimulation was also found within ocular
dominance columns of area V1 in monocularly deprived monkeys. Our
results suggest a high turnover rate of the
robl/LC7-like protein and the presence of a
repressor mechanism in neurons that is tightly coupled to synaptic stimulation.
Light-induced Down-regulation of the Rat Class 1 Dynein-associated Protein robl/LC7-like Gene in
Visual Cortex*
,, and
*
This work was supported by grants from the Medical Research
Council of Canada and Natural Sciences and Engineering Research Council
of Canada (to A. C.).The costs of publication of this article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Contributed equally to the results of this work.
§
To whom correspondence should be addressed: Dept. of Psychology,
McGill University 1205 Dr. Penfield Ave., Montreal, QC H3A 1B1 Canada.
Tel.: 514-398-6088; Fax: 514-398-4896; E-mail: avi@hebb. psych.mcgill.ca.
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