|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 275, Issue 36, 27566-27575, September 8, 2000
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the Centre for Molecular Inflammation and Vascular Research,
Department of Medicine and Therapeutics, Mater Misericordiae Hospital
and the Conway Institute of Biomolecular and Biomedical Research,
University College Dublin, 41 Eccles St.,
Dublin 7, Ireland
The lipoxygenase-derived eicosanoids
leukotrienes and lipoxins are well defined regulators of hemeodynamics
and leukocyte recruitment in inflammatory conditions. Here, we describe
a novel bioaction of lipoxin A4
(LXA4), namely inhibition of leukotriene D4 (LTD4)-induced human renal mesangial
cell proliferation, and investigate the signal transduction
mechanisms involved. LXA4 blocked
LTD4-stimulated phosphatidylinositol 3-kinase (PI 3-kinase) activity in parallel to inhibition of LTD4-induced
mesangial cell proliferation. Screening of a human mesangial
cell cDNA library revealed expression of the recently described
cys-leukotriene1/LTD4 receptor.
LTD4-induced mesangial cell proliferation required both extracellular-related signal regulated kinase (erk) and PI 3-kinase activation and may involve platelet-derived growth factor receptor transactivation. LTD4-stimulated the MAP kinases erk and
p38 via a pertussis toxin (PTX)-sensitive pathway dependent on PI
3-kinase and protein kinase C activation. On screening a cDNA
library, mesangial cells were found to express the previously described LXA4 receptor. In contrast to LTD4,
LXA4 showed differential activation of erk and p38.
LXA4 activation of erk was insensitive to PTX and PI
3-kinase inhibition, whereas LXA4 activation of p38 was sensitive to PTX and could be blocked by the LTD4 receptor
antagonist SKF 104353. These data suggest that LXA4
stimulation of the MAP kinase superfamily involves two distinct
receptors: one shared with LTD4 and coupled to a
PTX-sensitive G protein (Gi) and a second coupled via an
alternative G protein, such as Gq or G12, to
erk activation. These data expand on the spectrum of LXA4
bioactions within an inflammatory milieu.
Lipoxin A4 Antagonizes the Mitogenic Effects of
Leukotriene D4 in Human Renal Mesangial Cells
DIFFERENTIAL ACTIVATION OF MAP KINASES THROUGH DISTINCT
RECEPTORS*
,
*
This work was funded by grants from The Health Research
Board, Forbairt (Enterprise Ireland), and The Wellcome Trust.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Current address: Imperial Cancer Research Fund Medical
Oncology Unit, Western General Hospital National Health Service Trust, Edinburgh EH4 2XU, United Kingdom.
§
Current address: Sir Patrick Dun's Research Laboratories, Trinity
College Medical School, St. James Hospital, Dublin 8, Ireland.
¶
To whom correspondence should be addressed. Tel.:
353-1-803-2188; Fax: 353-1-830-8404; E-mail: cgodson@mater.ie.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  V. Martins, S. S. Valenca, F. A. Farias-Filho, R. Molinaro, R. L. Simoes, T. P. T. Ferreira, P. M. R. e Silva, C. M. Hogaboam, S. L. Kunkel, I. M. Fierro, et al. ATLa, an Aspirin-Triggered Lipoxin A4 Synthetic Analog, Prevents the Inflammatory and Fibrotic Effects of Bleomycin-Induced Pulmonary Fibrosis J. Immunol., May 1, 2009; 182(9): 5374 - 5381. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Baker, S. J. O'Meara, M. Scannell, P. Maderna, and C. Godson Lipoxin A4: Anti-Inflammatory and Anti-Angiogenic Impact on Endothelial Cells J. Immunol., March 15, 2009; 182(6): 3819 - 3826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. El Kebir, L. Jozsef, and J. G. Filep Opposing regulation of neutrophil apoptosis through the formyl peptide receptor-like 1/lipoxin A4 receptor: implications for resolution of inflammation J. Leukoc. Biol., September 1, 2008; 84(3): 600 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. El Kebir, L. Jozsef, T. Khreiss, W. Pan, N. A. Petasis, C. N. Serhan, and J. G. Filep Aspirin-Triggered Lipoxins Override the Apoptosis-Delaying Action of Serum Amyloid A in Human Neutrophils: A Novel Mechanism for Resolution of Inflammation J. Immunol., July 1, 2007; 179(1): 616 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Mitchell, S. J. O'Meara, A. Gaffney, J. K. G. Crean, B. T. Kinsella, and C. Godson The Lipoxin A4 Receptor Is Coupled to SHP-2 Activation: IMPLICATIONS FOR REGULATION OF RECEPTOR TYROSINE KINASES J. Biol. Chem., May 25, 2007; 282(21): 15606 - 15618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Chiang, C. N. Serhan, S.-E. Dahlen, J. M. Drazen, D. W. P. Hay, G. E. Rovati, T. Shimizu, T. Yokomizo, and C. Brink The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo Pharmacol. Rev., September 1, 2006; 58(3): 463 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bonnans, K. Fukunaga, R. Keledjian, N. A. Petasis, and B. D. Levy Regulation of phosphatidylinositol 3-kinase by polyisoprenyl phosphates in neutrophil-mediated tissue injury J. Exp. Med., April 17, 2006; 203(4): 857 - 863. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Fu, J. Karlsson, J. Bylund, C. Movitz, A. Karlsson, and C. Dahlgren Ligand recognition and activation of formyl peptide receptors in neutrophils J. Leukoc. Biol., February 1, 2006; 79(2): 247 - 256. [Full Text] [PDF]
|
|
|
|
 |
|
 S.-H. Wu, X.-H. Wu, C. Lu, L. Dong, and Z.-Q. Chen Lipoxin A4 Inhibits Proliferation of Human Lung Fibroblasts Induced by Connective TissueGrowth Factor Am. J. Respir. Cell Mol. Biol., January 1, 2006; 34(1): 65 - 72. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Rodgers, B. McMahon, D. Mitchell, D. Sadlier, and C. Godson Lipoxin A4 Modifies Platelet-Derived Growth Factor-Induced Profibrotic Gene Expression in Human Renal Mesangial Cells Am. J. Pathol., September 1, 2005; 167(3): 683 - 694. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Nascimento-Silva, M. A. Arruda, C. Barja-Fidalgo, C. G. Villela, and I. M. Fierro Novel lipid mediator aspirin-triggered lipoxin A4 induces heme oxygenase-1 in endothelial cells Am J Physiol Cell Physiol, September 1, 2005; 289(3): C557 - C563. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. L. Simoes and I. M. Fierro Involvement of the Rho-Kinase/Myosin Light Chain Kinase Pathway on Human Monocyte Chemotaxis Induced by ATL-1, an Aspirin-Triggered Lipoxin A4 Synthetic Analog J. Immunol., August 1, 2005; 175(3): 1843 - 1850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Maderna, S. Yona, M. Perretti, and C. Godson Modulation of Phagocytosis of Apoptotic Neutrophils by Supernatant from Dexamethasone-Treated Macrophages and Annexin-Derived Peptide Ac2-26 J. Immunol., March 15, 2005; 174(6): 3727 - 3733. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Ohse, T. Ota, N. Kieran, C. Godson, K. Yamada, T. Tanaka, T. Fujita, and M. Nangaku Modulation of Interferon-Induced Genes by Lipoxin Analogue in Anti-Glomerular Basement Membrane Nephritis J. Am. Soc. Nephrol., April 1, 2004; 15(4): 919 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Mitchell, K. Rodgers, J. Hanly, B. McMahon, H. R. Brady, F. Martin, and C. Godson Lipoxins Inhibit Akt/PKB Activation and Cell Cycle Progression in Human Mesangial Cells Am. J. Pathol., March 1, 2004; 164(3): 937 - 946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. McMahon and C. Godson Lipoxins: endogenous regulators of inflammation Am J Physiol Renal Physiol, February 1, 2004; 286(2): F189 - F201. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ariel, N. Chiang, M. Arita, N. A. Petasis, and C. N. Serhan Aspirin-Triggered Lipoxin A4 and B4 Analogs Block Extracellular Signal-Regulated Kinase-Dependent TNF-{alpha} Secretion from Human T Cells J. Immunol., June 15, 2003; 170(12): 6266 - 6272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kucharzik, A. T. Gewirtz, D. Merlin, J. L. Madara, and I. R. Williams Lateral membrane LXA4 receptors mediate LXA4's anti-inflammatory actions on intestinal epithelium Am J Physiol Cell Physiol, April 1, 2003; 284(4): C888 - C896. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Brink, S.-E. Dahlen, J. Drazen, J. F. Evans, D. W. P. Hay, S. Nicosia, C. N. Serhan, T. Shimizu, and T. Yokomizo International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors Pharmacol. Rev., March 1, 2003; 55(1): 195 - 227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. J. Schottelius, C. Giesen, K. Asadullah, I. M. Fierro, S. P. Colgan, J. Bauman, W. Guilford, H. D. Perez, and J. F. Parkinson An Aspirin-Triggered Lipoxin A4 Stable Analog Displays a Unique Topical Anti-Inflammatory Profile J. Immunol., December 15, 2002; 169(12): 7063 - 7070. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Mitchell, G. Thomas, K. Harvey, D. Cottell, K. Reville, G. Berlasconi, N. A. Petasis, L. Erwig, A. J. Rees, J. Savill, et al. Lipoxins, Aspirin-Triggered Epi-Lipoxins, Lipoxin Stable Analogues, and the Resolution of Inflammation: Stimulation of Macrophage Phagocytosis of Apoptotic Neutrophils In Vivo J. Am. Soc. Nephrol., October 1, 2002; 13(10): 2497 - 2507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. W. Vaughn, R. J. Proske, and D. L. Haviland Identification, Cloning, and Functional Characterization of a Murine Lipoxin A4 Receptor Homologue Gene J. Immunol., September 15, 2002; 169(6): 3363 - 3369. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bonnans, I. Vachier, C. Chavis, P. Godard, J. Bousquet, and P. Chanez Lipoxins Are Potential Endogenous Antiinflammatory Mediators in Asthma Am. J. Respir. Crit. Care Med., June 1, 2002; 165(11): 1531 - 1535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. O. Leonard, K. Hannan, M. J. Burne, D. W. P. Lappin, P. Doran, P. Coleman, C. Stenson, C. T. Taylor, F. Daniels, C. Godson, et al. 15-Epi-16-(Para-Fluorophenoxy)-Lipoxin A4-Methyl Ester, a Synthetic Analogue of 15-epi-Lipoxin A4, Is Protective in Experimental Ischemic Acute Renal Failure J. Am. Soc. Nephrol., June 1, 2002; 13(6): 1657 - 1662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Fierro, J. L. Kutok, and C. N. Serhan Novel Lipid Mediator Regulators of Endothelial Cell Proliferation and Migration: Aspirin-Triggered-15R-Lipoxin A4 and Lipoxin A4 J. Pharmacol. Exp. Ther., February 1, 2002; 300(2): 385 - 392. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Goh, A. W. Baird, C. O'Keane, R. W. G. Watson, D. Cottell, G. Bernasconi, N. A. Petasis, C. Godson, H. R. Brady, and P. MacMathuna Lipoxin A4 and Aspirin-Triggered 15-Epi-Lipoxin A4 Antagonize TNF-{alpha}-Stimulated Neutrophil-Enterocyte Interactions In Vitro and Attenuate TNF-{alpha}-Induced Chemokine Release and Colonocyte Apoptosis in Human Intestinal Mucosa Ex Vivo J. Immunol., September 1, 2001; 167(5): 2772 - 2780. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. T. Hii, N. Moghadammi, A. Dunbar, and A. Ferrante Activation of the Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B Signaling Pathway in Arachidonic Acid-stimulated Human Myeloid and Endothelial Cells. INVOLVEMENT OF THE ErbB RECEPTOR FAMILY J. Biol. Chem., July 13, 2001; 276(29): 27246 - 27255. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |