|
|
|
|||||||
|
|||||||||
J. Biol. Chem., Vol. 275, Issue 36, 28291-28300, September 8, 2000
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
From the The liver-specific vitellogenin B1 promoter is
efficiently activated by estrogen within a nucleosomal environment
after microinjection into Xenopus laevis oocytes,
consistent with the hypothesis that significant nucleosome remodeling
over this promoter is not a prerequisite for the activation by the
estrogen receptor (ER
Determinants of Vitellogenin B1 Promoter Architecture
HNF3 AND ESTROGEN RESPONSIVE TRANSCRIPTION WITHIN CHROMATIN*
§¶
,**
Institut de Biologie animale,
Université de Lausanne, Bâtiment de Biologie, CH-1015
Lausanne, Switzerland and the § Laboratory of Molecular
Embryology, NICHD, National Institutes of Health,
Bethesda, Maryland 20892-5431
). This observation lead us to investigate
determinants other than ER of chromatin structure and
transcriptional activation of the vitellogenin B1 promoter in this
system and in vitro. We find that the liver-enriched
transcription factor HNF3 has an important organizational role for
chromatin structure as demonstrated by DNase I-hypersensitive site
mapping. Both HNF3 and the estrogen receptor activate transcription
synergistically and are able to interact with chromatin reconstituted
in vitro with three positioned nucleosomes. We propose that
HNF3 is the cellular determinant which establishes a promoter
environment favorable to a rapid transcriptional activation by the
estrogen receptor.
*
This work was supported by the Etat de Vaud, Swiss National
Science Foundation, "Fondation du 450e Anniversaire," and the National Institutes of Health.The costs of publication of this article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Present address: Dept. of Biological Chemistry, Molecular
Biology Inst., University of California, Los Angeles, CA 90095.
**
To whom correspondence should be addressed. Tel.: 41-21-692-41-10;
Fax: 41-21-692-41-15; E-mail walter.wahli@iba.unil.ch.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  M A Thorat, C Marchio, A Morimiya, K Savage, H Nakshatri, J S Reis-Filho, and S Badve Forkhead box A1 expression in breast cancer is associated with luminal subtype and good prognosis J. Clin. Pathol., March 1, 2008; 61(3): 327 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Krieg, E. M. Hammond, and A. J. Giaccia Functional Analysis of p53 Binding under Differential Stresses. Mol. Cell. Biol., October 1, 2006; 26(19): 7030 - 7045. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Laganiere, G. Deblois, C. Lefebvre, A. R. Bataille, F. Robert, and V. Giguere From the Cover: Location analysis of estrogen receptor {alpha} target promoters reveals that FOXA1 defines a domain of the estrogen response PNAS, August 16, 2005; 102(33): 11651 - 11656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Gao, J. Zhang, M. A. Rao, T. C. Case, J. Mirosevich, Y. Wang, R. Jin, A. Gupta, P. S. Rennie, and R. J. Matusik The Role of Hepatocyte Nuclear Factor-3{alpha} (Forkhead Box A1) and Androgen Receptor in Transcriptional Regulation of Prostatic Genes Mol. Endocrinol., August 1, 2003; 17(8): 1484 - 1507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. D. Marsden and R. E. K. Fournier Chromosomal Elements Regulate Gene Activity and Chromatin Structure of the Human Serpin Gene Cluster at 14q32.1 Mol. Cell. Biol., May 15, 2003; 23(10): 3516 - 3526. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Gauthier, V. M. Schwitzgebel, M. Zaiko, A. Mamin, B. Ritz-Laser, and J. Philippe Hepatic Nuclear Factor-3 (HNF-3 or Foxa2) Regulates Glucagon Gene Transcription by Binding to the G1 and G2 Promoter Elements Mol. Endocrinol., January 1, 2002; 16(1): 170 - 183. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gegonne, J. D. Weissman, and D. S. Singer TAFII55 binding to TAFII250 inhibits its acetyltransferase activity PNAS, October 5, 2001; (2001) 211444798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. West, C. Blanchette, H. Dressman, E. Huang, S. Ishida, R. Spang, H. Zuzan, J. A. Olson Jr., J. R. Marks, and J. R. Nevins Predicting the clinical status of human breast cancer by using gene expression profiles PNAS, September 13, 2001; (2001) 201162998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. West, C. Blanchette, H. Dressman, E. Huang, S. Ishida, R. Spang, H. Zuzan, J. A. Olson Jr., J. R. Marks, and J. R. Nevins Predicting the clinical status of human breast cancer by using gene expression profiles PNAS, September 25, 2001; 98(20): 11462 - 11467. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gegonne, J. D. Weissman, and D. S. Singer TAFII55 binding to TAFII250 inhibits its acetyltransferase activity PNAS, October 23, 2001; 98(22): 12432 - 12437. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |