JBC Avanti Polar Lipids

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M907635199 on June 7, 2000

J. Biol. Chem., Vol. 275, Issue 37, 28750-28756, September 15, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/37/28750    most recent
M907635199v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Versteeg, H. H.
Right arrow Articles by Peppelenbosch, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Versteeg, H. H.
Right arrow Articles by Peppelenbosch, M. P.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Factor VIIa/Tissue Factor-induced Signaling via Activation of Src-like Kinases, Phosphatidylinositol 3-Kinase, and Rac*

Henri H. VersteegDagger §, Inge HoedemaekerDagger , Sander H. DiksDagger , Jord C. Stam, Marcel Spaargaren||, Paul M. P. van Bergen en Henegouwen, Sander J. H. van DeventerDagger , and Maikel P. PeppelenboschDagger **

From the Dagger  Laboratory for Experimental Internal Medicine, G2-130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands, the  Institute of Biomembranes, Department of Molecular Cell Biology, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands, and the || Department of Pathology, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands

Tissue factor (TF), apart from activating the extrinsic pathway of the blood coagulation, is a principal regulator of embryonic angiogenesis and oncogenic neoangiogenesis, but also influences inflammation, leukocyte diapedesis and tumor progression. The intracellular domain of TF lacks homology to other classes of receptors and hence the signaling mechanism is poorly understood. Here we demonstrate that factor VIIa (the natural ligand for TF) induces the activation of the Src family members c-Src, Lyn, and Yes, and subsequently phosphatidylinositol 3-kinase (PI3K), followed by stimulation of c-Akt/protein kinase B as well as the small GTPases Rac and Cdc42. In turn Rac mediates p38 mitogen-activated protein (MAP) kinase activation and cytoskeletal reorganization, whereas factor VIIa-induced p42/p44 MAP kinase stimulation required PI3K enzymatic activity but was not inhibited by dominant negative Rac proteins. We propose that this Src family member/PI3K/Rac-dependent signaling pathway is a major mediator of factor VIIa/TF effects in pathophysiology.

* This study was supported in part by a grant (UVA 98-1855) from the Dutch Cancer Society (Koningin Wilhelmina Fonds).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ Supported by an Ambrosius fellowship.

** To whom correspondence should be addressed: Tel.: 31-20-566-5910; Fax: 31-20-697-7192; E-mail: m.p.peppelenbosch@amc.uva.nl.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Am. J. Pathol.Home page
K. Borensztajn, J. Stiekema, S. Nijmeijer, P. H. Reitsma, M. P. Peppelenbosch, and C. A. Spek
Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation
Am. J. Pathol., February 1, 2008; 172(2): 309 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
A. Siegbahn, M. Johnell, A. Nordin, M. Aberg, and T. Velling
TF/FVIIa Transactivate PDGFR to Regulate PDGF-BB Induced Chemotaxis in Different Cell Types: Involvement of Src And PLC
Arterioscler. Thromb. Vasc. Biol., January 1, 2008; 28(1): 135 - 141.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. K. Mandal, U. R. Pendurthi, and L. V. M. Rao
Tissue factor trafficking in fibroblasts: involvement of protease-activated receptor-mediated cell signaling
Blood, July 1, 2007; 110(1): 161 - 170.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Dejmek, A. Safholm, C. Kamp Nielsen, T. Andersson, and K. Leandersson
Wnt-5a/Ca2+-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1{alpha} Signaling in Human Mammary Epithelial Cells.
Mol. Cell. Biol., August 1, 2006; 26(16): 6024 - 6036.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
E. K. Jackson, L. Gao, and C. Zhu
Mechanism of the Vascular Angiotensin II/{alpha}2-Adrenoceptor Interaction
J. Pharmacol. Exp. Ther., September 1, 2005; 314(3): 1109 - 1116.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
N. Nitori, Y. Ino, Y. Nakanishi, T. Yamada, K. Honda, K. Yanagihara, T. Kosuge, Y. Kanai, M. Kitajima, and S. Hirohashi
Prognostic Significance of Tissue Factor in Pancreatic Ductal Adenocarcinoma
Clin. Cancer Res., April 1, 2005; 11(7): 2531 - 2539.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
I. Ott, B. Weigand, R. Michl, I. Seitz, N. Sabbari-Erfani, F.-J. Neumann, and A. Schomig
Tissue Factor Cytoplasmic Domain Stimulates Migration by Activation of the GTPase Rac1 and the Mitogen-Activated Protein Kinase p38
Circulation, January 25, 2005; 111(3): 349 - 355.
[Abstract] [Full Text] [PDF]

Home page
 Arterioscler. Thromb. Vasc. Bio.Home page
L. V. M. Rao and U. R. Pendurthi
Tissue Factor-Factor VIIa Signaling
Arterioscler. Thromb. Vasc. Biol., January 1, 2005; 25(1): 47 - 56.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
H. H. Versteeg, C. A. Spek, S. H. Slofstra, S. H. Diks, D. J. Richel, and M. P. Peppelenbosch
FVIIa:TF Induces Cell Survival via G12/G13-Dependent Jak/STAT Activation and BclXL Production
Circ. Res., April 30, 2004; 94(8): 1032 - 1040.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
B. B. Sorensen, L. V. M. Rao, D. Tornehave, S. Gammeltoft, and L. C. Petersen
Antiapoptotic effect of coagulation factor VIIa
Blood, September 1, 2003; 102(5): 1708 - 1715.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
H. H. Versteeg, M. P. Peppelenbosch, and C. A. Spek
Tissue factor signal transduction in angiogenesis
Carcinogenesis, June 1, 2003; 24(6): 1009 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Qian, J. Luo, S. S. Leonard, G. K. Harris, L. Millecchia, D. C. Flynn, and X. Shi
Hydrogen Peroxide Formation and Actin Filament Reorganization by Cdc42 Are Essential for Ethanol-induced in Vitro Angiogenesis
J. Biol. Chem., April 25, 2003; 278(18): 16189 - 16197.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. C. M. Morel, C. C. Park, K. Zhu, P. Kumar, J. H. Ruth, and A. E. Koch
Signal Transduction Pathways Involved in Rheumatoid Arthritis Synovial Fibroblast Interleukin-18-induced Vascular Cell Adhesion Molecule-1 Expression
J. Biol. Chem., September 13, 2002; 277(38): 34679 - 34691.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. H. Versteeg, B. B. Sorensen, S. H. Slofstra, J. H. M. Van den Brande, J. C. Stam, P. M. P. van Bergen en Henegouwen, D. J. Richel, L. C. Petersen, and M. P. Peppelenbosch
VIIa/Tissue Factor Interaction Results in a Tissue Factor Cytoplasmic Domain-independent Activation of Protein Synthesis, p70, and p90 S6 Kinase Phosphorylation
J. Biol. Chem., July 19, 2002; 277(30): 27065 - 27072.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Wang, E. Gjernes, and H. Prydz
Factor VIIa Induces Tissue Factor-dependent Up-regulation of Interleukin-8 in a Human Keratinocyte Line
J. Biol. Chem., June 21, 2002; 277(26): 23620 - 23626.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
R. Liu, K. Aupperle, and R. Terkeltaub
Src family protein tyrosine kinase signaling mediates monosodium urate crystal-induced IL-8 expression by monocytic THP-1 cells
J. Leukoc. Biol., December 1, 2001; 70(6): 961 - 968.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Iakhiaev, U. R. Pendurthi, and L. V. M. Rao
Active Site Blockade of Factor VIIa Alters Its Intracellular Distribution
J. Biol. Chem., November 30, 2001; 276(49): 45895 - 45901.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
U. Kintscher, S. Wakino, S. Kim, E. Fleck, W. A. Hsueh, and R. E. Law
Angiotensin II Induces Migration and Pyk2/Paxillin Phosphorylation of Human Monocytes
Hypertension, February 1, 2001; 37(2): 587 - 593.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.