| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 4, 2251-2254, January 28, 2000
,,¶
From the Taxol, an antitumor agent derived from a plant,
mimics the action of lipopolysaccharide (LPS) in mice but not in
humans. Although Taxol is structurally unrelated to LPS, Taxol and LPS
are presumed to share a receptor or signaling molecule. The LPS-mimetic
activity of Taxol is not observed in LPS-hyporesponsive C3H/HeJ mice,
which possess a point mutation in Toll-like receptor 4 (TLR4);
therefore, TLR4 appears to be involved in both Taxol and LPS signaling.
In addition, TLR4 was recently shown to physically associate with MD-2,
a molecule that confers LPS responsiveness on TLR4. To determine whether TLR4·MD-2 complex mediates a Taxol-induced signal, we constructed transformants of the mouse pro-B cell line, Ba/F3, expressing mouse TLR4 alone, both mouse TLR4 and mouse MD-2, and both
mouse MD-2 and mouse TLR4 lacking the cytoplasmic portion, and then
examined whether Taxol induced NF Department of Biochemistry and Cell Biology,
National Institute of Infectious Diseases, Toyama, 1-23-1, Shinjyuku-ku, Tokyo 162-8640, Japan and the § Department of
Immunology, Saga Medical School, Nabeshima, Saga 849-8501, Japan
B activation in these transfectants. Noticeable NFB activation by Taxol was detected in
Ba/F3 expressing mouse TLR4 and mouse MD-2 but not in the other transfectants. Coexpression of human TLR4 and human MD-2 did not confer
Taxol responsiveness on Ba/F3 cells, suggesting that the TLR4·MD-2
complex is responsible for the species specificity with respect to
Taxol responsiveness. Furthermore, Taxol-induced NFB activation via
TLR4·MD-2 was blocked by an LPS antagonist that blocks LPS-induced
NFB activation via TLR4·MD-2. These results demonstrated that
coexpression of mouse TLR4 and mouse MD-2 is required for Taxol
responsiveness and that the TLR4·MD-2 complex is the shared molecule
in Taxol and LPS signal transduction in mice.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Rallabhandi, A. Awomoyi, K. E. Thomas, A. Phalipon, Y. Fujimoto, K. Fukase, S. Kusumoto, N. Qureshi, M. B. Sztein, and S. N. Vogel Differential Activation of Human TLR4 by Escherichia coli and Shigella flexneri 2a Lipopolysaccharide: Combined Effects of Lipid A Acylation State and TLR4 Polymorphisms on Signaling J. Immunol., January 15, 2008; 180(2): 1139 - 1147. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Lohmann, M. L. Vandenplas, M. H. Barton, C. E. Bryant, and J. N. Moore The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist Innate Immunity, August 1, 2007; 13(4): 235 - 242. [Abstract] [PDF]
|
|
|
|
 |
|
 S. M Zimmer, S. M Zughaier, Y.-L. Tzeng, and D. S Stephens Human MD-2 discrimination of meningococcal lipid A structures and activation of TLR4 Glycobiology, August 1, 2007; 17(8): 847 - 856. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Linde, D. Mosier, F. Blecha, and T. Melgarejo Innate immunity and inflammation - New frontiers in comparative cardiovascular pathology Cardiovasc Res, January 1, 2007; 73(1): 26 - 36. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Du, F. Zhang, J. E. Capo-Aponte, S. D. Tachado, J. Zhang, F.-S. X. Yu, R. A. Sack, H. Koziel, and P. S. Reinach AsialoGM1-Mediated IL-8 Release by Human Corneal Epithelial Cells Requires Coexpression of TLR5 Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4810 - 4818. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, I. Sabroe, J. D. Hasday, and S. N. Vogel Invited review: Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease Innate Immunity, June 1, 2006; 12(3): 133 - 150. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Viriyakosol, P. S. Tobias, and T. N. Kirkland Mutational Analysis of Membrane and Soluble Forms of Human MD-2 J. Biol. Chem., April 28, 2006; 281(17): 11955 - 11964. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Okemoto, K. Kawasaki, K. Hanada, M. Miura, and M. Nishijima A Potent Adjuvant Monophosphoryl Lipid A Triggers Various Immune Responses, but Not Secretion of IL-1{beta} or Activation of Caspase-1 J. Immunol., January 15, 2006; 176(2): 1203 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. O. Omueti, J. M. Beyer, C. M. Johnson, E. A. Lyle, and R. I. Tapping Domain Exchange between Human Toll-like Receptors 1 and 6 Reveals a Region Required for Lipopeptide Discrimination J. Biol. Chem., November 4, 2005; 280(44): 36616 - 36625. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Wahl, N. J. Goetsch, H. J. Young, R. J. Van Maanen, J. D. Johnson, A. S. Pea, and A. Brittingham Murine Macrophages Produce Endothelin-1 After Microbial Stimulation Experimental Biology and Medicine, October 1, 2005; 230(9): 652 - 658. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Emens and E. M. Jaffee Leveraging the Activity of Tumor Vaccines with Cytotoxic Chemotherapy Cancer Res., September 15, 2005; 65(18): 8059 - 8064. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L A Emens, R T Reilly, and E M Jaffee Breast cancer vaccines: maximizing cancer treatment by tapping into host immunity Endocr. Relat. Cancer, March 1, 2005; 12(1): 1 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawasaki, R. K. Ernst, and S. I. Miller Purification and characterization of deacylated and/or palmitoylated lipid A species unique to Salmonella enterica serovar Typhimurium Innate Immunity, February 1, 2005; 11(1): 57 - 61. [Abstract] [PDF]
|
|
|
|
 |
|
 K. Takeda and S. Akira Toll-like receptors in innate immunity Int. Immunol., January 1, 2005; 17(1): 1 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawasaki, R. K. Ernst, and S. I. Miller Deacylation and palmitoylation of lipid A by Salmonellae outer membrane enzymes modulate host signaling through Toll-like receptor 4 Innate Immunity, December 1, 2004; 10(6): 439 - 444. [Abstract] [PDF]
|
|
|
|
|
|
T. Fujimoto, S. Yamazaki, A. Eto-Kimura, K. Takeshige, and T. Muta The Amino-terminal Region of Toll-like Receptor 4 Is Essential for Binding to MD-2 and Receptor Translocation to the Cell Surface J. Biol. Chem., November 12, 2004; 279(46): 47431 - 47437. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-C. Oliveira, J. R. Peixoto, L. B. de Arruda, M. A. Campos, R. T. Gazzinelli, D. T. Golenbock, S. Akira, J. O. Previato, L. Mendonca-Previato, A. Nobrega, et al. Expression of Functional TLR4 Confers Proinflammatory Responsiveness to Trypanosoma cruzi Glycoinositolphospholipids and Higher Resistance to Infection with T. cruzi J. Immunol., November 1, 2004; 173(9): 5688 - 5696. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. J. Chong, A. Shimamoto, C. R. Hampton, H. Takayama, D. J. Spring, C. L. Rothnie, M. Yada, T. H. Pohlman, and E. D. Verrier Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart J. Thorac. Cardiovasc. Surg., August 1, 2004; 128(2): 170 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Gruber, M. Mancek, H. Wagner, C. J. Kirschning, and R. Jerala Structural Model of MD-2 and Functional Role of Its Basic Amino Acid Clusters Involved in Cellular Lipopolysaccharide Recognition J. Biol. Chem., July 2, 2004; 279(27): 28475 - 28482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawasaki, R. K. Ernst, and S. I. Miller 3-O-Deacylation of Lipid A by PagL, a PhoP/PhoQ-regulated Deacylase of Salmonella typhimurium, Modulates Signaling through Toll-like Receptor 4 J. Biol. Chem., May 7, 2004; 279(19): 20044 - 20048. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Okamoto, G. Oh-e, T. Oshikawa, S. Furuichi, T. Tano, S. U. Ahmed, S. Akashi, K. Miyake, O. Takeuchi, S. Akira, et al. Toll-Like Receptor 4 Mediates the Antitumor Host Response Induced by a 55-Kilodalton Protein Isolated from Aeginetia indica L., a Parasitic Plant Clin. Vaccine Immunol., May 1, 2004; 11(3): 483 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Basu and M. J. Fenton Toll-like receptors: function and roles in lung disease Am J Physiol Lung Cell Mol Physiol, May 1, 2004; 286(5): L887 - L892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Anders, B. Banas, and D. Schlondorff Signaling Danger: Toll-Like Receptors and their Potential Roles in Kidney Disease J. Am. Soc. Nephrol., April 1, 2004; 15(4): 854 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Oshiumi, M. Sasai, K. Shida, T. Fujita, M. Matsumoto, and T. Seya TIR-containing Adapter Molecule (TICAM)-2, a Bridging Adapter Recruiting to Toll-like Receptor 4 TICAM-1 That Induces Interferon-{beta} J. Biol. Chem., December 12, 2003; 278(50): 49751 - 49762. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawasaki, K. Gomi, Y. Kawai, M. Shiozaki, and M. Nishijima Molecular basis for lipopolysaccharide mimetic action of TaxolTM and flavolipin Innate Immunity, October 1, 2003; 9(5): 301 - 307. [Abstract] [PDF]
|
|
|
|
|
|
J. Zhang, K. Xu, B. Ambati, and F.-S. X. Yu Toll-like Receptor 5-Mediated Corneal Epithelial Inflammatory Responses to Pseudomonas aeruginosa Flagellin Invest. Ophthalmol. Vis. Sci., October 1, 2003; 44(10): 4247 - 4254. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Pinhal-Enfield, M. Ramanathan, G. Hasko, S. N. Vogel, A. L. Salzman, G.-J. Boons, and S. J. Leibovich An Angiogenic Switch in Macrophages Involving Synergy between Toll-Like Receptors 2, 4, 7, and 9 and Adenosine A2A Receptors Am. J. Pathol., August 1, 2003; 163(2): 711 - 721. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. C. Malcolm and G. S. Worthen Lipopolysaccharide Stimulates p38-dependent Induction of Antiviral Genes in Neutrophils Independently of Paracrine Factors J. Biol. Chem., April 25, 2003; 278(18): 15693 - 15701. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dunne and L. A. J. O'Neill The Interleukin-1 Receptor/Toll-Like Receptor Superfamily: Signal Transduction During Inflammation and Host Defense Sci. Signal., February 25, 2003; 2003(171): re3 - re3. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Okamoto, T. Oshikawa, T. Tano, G. Ohe, S. Furuichi, H. Nishikawa, S. U. Ahmed, S. Akashi, K. Miyake, O. Takeuchi, et al. Involvement of Toll-Like Receptor 4 Signaling in Interferon-{gamma} Production and Antitumor Effect by Streptococcal Agent OK-432 J Natl Cancer Inst, February 19, 2003; 95(4): 316 - 326. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Liwu Li, R. Jacinto, B. Yoza, and C. E. McCall Distinct post-receptor alterations generate gene- and signal-selective adaptation and cross-adaptation of TLR4 and TLR2 in human leukocytes Innate Immunity, February 1, 2003; 9(1): 39 - 44. [Abstract] [PDF]
|
|
|
|
|
|
A. E. Medvedev and S. N. Vogel Overexpression of CD14, TLR4, and MD-2 in HEK 293T cells does not prevent induction of in vitro endotoxin tolerance Innate Immunity, February 1, 2003; 9(1): 60 - 64. [Abstract] [PDF]
|
|
|
|
|
|
Y. I. Miller, S. Viriyakosol, C. J. Binder, J. R. Feramisco, T. N. Kirkland, and J. L. Witztum Minimally Modified LDL Binds to CD14, Induces Macrophage Spreading via TLR4/MD-2, and Inhibits Phagocytosis of Apoptotic Cells J. Biol. Chem., January 10, 2003; 278(3): 1561 - 1568. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawasaki, H. Nogawa, and M. Nishijima Identification of Mouse MD-2 Residues Important for Forming the Cell Surface TLR4-MD-2 Complex Recognized by Anti-TLR4-MD-2 Antibodies, and for Conferring LPS and Taxol Responsiveness on Mouse TLR4 by Alanine-Scanning Mutagenesis J. Immunol., January 1, 2003; 170(1): 413 - 420. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, A. Lentschat, L. M. Wahl, D. T. Golenbock, and S. N. Vogel Dysregulation of LPS-Induced Toll-Like Receptor 4-MyD88 Complex Formation and IL-1 Receptor-Associated Kinase 1 Activation in Endotoxin-Tolerant Cells J. Immunol., November 1, 2002; 169(9): 5209 - 5216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Muroi, T. Ohnishi, and K.-i. Tanamoto MD-2, a Novel Accessory Molecule, Is Involved in Species-Specific Actions of Salmonella Lipid A Infect. Immun., July 1, 2002; 70(7): 3546 - 3550. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M A Moscarello, B Mak, T A Nguyen, D D Wood, F Mastronardi, and S K Ludwin Paclitaxel (Taxol) attenuates clinical disease in a spontaneously demyelinating transgenic mouse and induces remyelination Multiple Sclerosis, April 1, 2002; 8(2): 130 - 138. [Abstract] [PDF]
|
|
|
|
|
|
K. Gomi, K. Kawasaki, Y. Kawai, M. Shiozaki, and M. Nishijima Toll-Like Receptor 4-MD-2 Complex Mediates the Signal Transduction Induced by Flavolipin, an Amino Acid-Containing Lipid Unique to Flavobacterium meningosepticum J. Immunol., March 15, 2002; 168(6): 2939 - 2943. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Vasselon and P. A. Detmers Toll Receptors: a Central Element in Innate Immune Responses Infect. Immun., March 1, 2002; 70(3): 1033 - 1041. [Full Text] [PDF]
|
|
|
|
|
|
K. A. Zarember and P. J. Godowski Tissue Expression of Human Toll-Like Receptors and Differential Regulation of Toll-Like Receptor mRNAs in Leukocytes in Response to Microbes, Their Products, and Cytokines J. Immunol., January 15, 2002; 168(2): 554 - 561. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Termeer, F. Benedix, J. Sleeman, C. Fieber, U. Voith, T. Ahrens, K. Miyake, M. Freudenberg, C. Galanos, and J. C. Simon Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4 J. Exp. Med., January 7, 2002; 195(1): 99 - 111. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Akashi, Y. Nagai, H. Ogata, M. Oikawa, K. Fukase, S. Kusumoto, K. Kawasaki, M. Nishijima, S. Hayashi, M. Kimoto, et al. Human MD-2 confers on mouse Toll-like receptor 4 species-specific lipopolysaccharide recognition Int. Immunol., December 1, 2001; 13(12): 1595 - 1599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kawai, O. Takeuchi, T. Fujita, J.-i. Inoue, P. F. Muhlradt, S. Sato, K. Hoshino, and S. Akira Lipopolysaccharide Stimulates the MyD88-Independent Pathway and Results in Activation of IFN-Regulatory Factor 3 and the Expression of a Subset of Lipopolysaccharide-Inducible Genes J. Immunol., November 15, 2001; 167(10): 5887 - 5894. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. I. Song, T. A. Abraham, Y. Park, A. S. Zivony, B. Harten, H. F. Edelhauser, S. L. Ward, C. A. Armstrong, and J. C. Ansel The Expression of Functional LPS Receptor Proteins CD14 And Toll-Like Receptor 4 in Human Corneal Cells Invest. Ophthalmol. Vis. Sci., November 1, 2001; 42(12): 2867 - 2877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B W Jones, K A Heldwein, T K Means, J J Saukkonen, and M J Fenton Differential roles of Toll-like receptors in the elicitation of proinflammatory responses by macrophages Ann Rheum Dis, November 1, 2001; 60(90003): iii6 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Medvedev, P. Henneke, A. Schromm, E. Lien, R. Ingalls, M. J. Fenton, D. T. Golenbock, and S. N. Vogel Induction of Tolerance to Lipopolysaccharide and Mycobacterial Components in Chinese Hamster Ovary/CD14 Cells Is Not Affected by Overexpression of Toll-Like Receptors 2 or 4 J. Immunol., August 15, 2001; 167(4): 2257 - 2267. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Alexander and E. Th. Rietschel Invited review: Bacterial lipopolysaccharides and innate immunity Innate Immunity, June 1, 2001; 7(3): 167 - 202. [Abstract] [PDF]
|
|
|
|
|
|
T. K. Means, B. W. Jones, A. B. Schromm, B. A. Shurtleff, J. A. Smith, J. Keane, D. T. Golenbock, S. N. Vogel, and M. J. Fenton Differential Effects of a Toll-Like Receptor Antagonist on Mycobacterium tuberculosis-Induced Macrophage Responses J. Immunol., March 15, 2001; 166(6): 4074 - 4082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. S. George, H. Jin, C. L. Wohlford-Lenane, M. E. O'Neill, J. C. Phipps, P. O'Shaughnessy, J. N. Kline, P. S. Thorne, and D. A. Schwartz Endotoxin responsiveness and subchronic grain dust-induced airway disease Am J Physiol Lung Cell Mol Physiol, February 1, 2001; 280(2): L203 - L213. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Kawasaki, K. Gomi, and M. Nishijima Cutting Edge: Gln22 of Mouse MD-2 Is Essential for Species-Specific Lipopolysaccharide Mimetic Action of Taxol J. Immunol., January 1, 2001; 166(1): 11 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-Y. Perera, T. N. Mayadas, O. Takeuchi, S. Akira, M. Zaks-Zilberman, S. M. Goyert, and S. N. Vogel CD11b/CD18 Acts in Concert with CD14 and Toll-Like Receptor (TLR) 4 to Elicit Full Lipopolysaccharide and Taxol-Inducible Gene Expression J. Immunol., January 1, 2001; 166(1): 574 - 581. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Cario and D. K. Podolsky Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease Infect. Immun., December 1, 2000; 68(12): 7010 - 7017. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Viriyakosol, P. S. Tobias, R. L. Kitchens, and T. N. Kirkland MD-2 Binds to Bacterial Lipopolysaccharide J. Biol. Chem., October 5, 2001; 276(41): 38044 - 38051. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
