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J Biol Chem, Vol. 275, Issue 4, 2607-2612, January 28, 2000
From the Lumican regulates collagenous matrix
assembly as a keratan sulfate proteoglycan in the cornea and is also
present in the connective tissues of other organs and embryonic corneal
stroma as a glycoprotein. In normal unwounded cornea, lumican is
expressed by stromal keratocytes. Our data show that injured mouse
corneal epithelium ectopically and transiently expresses lumican during
the early phase of wound healing, suggesting a potential lumican
functionality unrelated to regulation of collagen fibrillogenesis,
e.g. modulation of epithelial cell adhesion or migration.
An anti-lumican antibody was found to retard corneal epithelial wound
healing in cultured mouse eyes. Healing of a corneal epithelial injury
in Lum
Role of Lumican in the Corneal Epithelium during Wound
Healing*
,,,,,, and
Department of Ophthalmology, University of
Cincinnati Medical Center, Cincinnati, Ohio 45267-0527 and the
§ Department of Ophthalmology, University of Pittsburgh,
Pittsburgh, Pennsylvania 15213
/ mice was significantly delayed
compared with Lum+/ mice. These observations
indicate that lumican expressed in injured epithelium may modulate cell
behavior such as adhesion or migration, thus contributing to corneal
epithelial wound healing.
*
This work was supported by Grants EY10556 and EY11845 from
the National Institutes of Health and the Ohio Lion's Eye Research Foundation (Columbus, OH) (to W. W.-Y. K); Grant EY09368 from the
National Institutes of Health and Grant KS-96-GS-2 from the American
Heart Association, Kansas Affiliate (to J. L. F); the Ministry of
Education, Culture, and Science of Japan, the Nippon Eye Bank
Association Fund (Tokyo, Japan), and a Bausch-Lomb overseas research
fellowship award (Tokyo) (to S. S).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence and reprint requests should be
addressed: Dept. of Ophthalmology, University of Cincinnati Medical Center, Health Professions Bldg., Suite 350, ML0527, Eden and Bethesda
Aves., Cincinnati, OH 45267-0527. Tel.: 513-558-5151; Fax:
513-558-3108; E-mail: Winston.Kao@UC.EDU.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
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