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J. Biol. Chem., Vol. 275, Issue 40, 30801-30805, October 6, 2000
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and
From the Molecular Endocrinology Laboratory, Imperial Cancer
Research Fund,London WC2A 3PX, United Kingdom
SRC1, initially identified as a nuclear receptor
coactivator, was found to interact with a member of the transcriptional
enhancer factor (TEF) family of transcription factors, TEF-4.
The interaction, which occurs in both intact cells and in a cell-free
system, is mediated by the highly conserved basic
helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) domain present in the N-terminal region of SRC1. Moreover, all three members of the p160 family of nuclear receptor coactivators, SRC1, TIF2, and RAC3, are able to potentiate transcription from a TEF
response element in transient transfection experiments, and this
activation requires the presence of the bHLH-PAS domain. These results
suggest that the p160 proteins could be bona fide coactivators of the TEF family of transcription factors.
Supported by the European Community Training and Mobility
of Researchers program.
§
To whom correspondence should be addressed. Tel.: 44-20-7269-3280;
Fax: 44-20-7269-3094; E-mail: m.parker@icrf.icnet.uk.
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