JBC PeproTech; Our Business is Cytokines!

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M003880200 on July 24, 2000

J. Biol. Chem., Vol. 275, Issue 44, 34306-34313, November 3, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/44/34306    most recent
M003880200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Montano, M. M.
Right arrow Articles by Bianco, N. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Montano, M. M.
Right arrow Articles by Bianco, N. R.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Identification and Characterization of a Novel Factor That Regulates Quinone Reductase Gene Transcriptional Activity*

Monica M. MontanoDagger , Bryan M. Wittmann, and Nicole R. Bianco

From the Department of Pharmacology, Case Western Reserve University, Cleveland, Ohio 44122

The regulation of the quinone reductase (QR) gene as well as other genes involved in detoxification is known to be mediated by an electrophile/antioxidant response element (EpRE/ARE). We have previously observed that QR is up-regulated by the antiestrogen trans-hydroxytamoxifen in breast cancer cells. QR gene regulation by the antiestrogen-occupied estrogen receptor (ER) is mediated by the EpRE-containing region of the human QR gene, and the ER is one of the complex of proteins that binds to the EpRE. In an effort to further understand the mechanism for ER regulation of QR gene we identified other protein factors that regulate QR gene transcriptional activity in breast cancer cells. One of these protein factors, hPMC2 (human homolog of Xenopus gene which prevents mitotic catastrophe), directly binds to the EpRE and interacts with the ER in yeast genetic screening and in vitro assays. Interestingly hPMC2 interacts more strongly to ERbeta when compared with ERalpha . In transient transfection assays using reporter constructs containing the EpRE, hPMC2 alone can slightly activate reporter in ER-negative MDA-MB-231 breast cancer cells. The activation of QR gene activity by hPMC2 is enhanced in the presence of ERbeta .

* This work was supported by National Institutes of Health Grant CA80959 (to M. M. M.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Case Western Reserve University School of Medicine, Dept. of Pharmacology, H. G. Wood Bldg. W307, 2109 Adelbert Rd., Cleveland, OH 44122. Tel.: 216-368-3378; Fax: 216-368-3395; E-mail: mxm126@po.cwru.edu.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. ProteomicsHome page
Y. Coute, K. Kindbeiter, S. Belin, R. Dieckmann, L. Duret, L. Bezin, J.-C. Sanchez, and J.-J. Diaz
ISG20L2, a Novel Vertebrate Nucleolar Exoribonuclease Involved in Ribosome Biogenesis
Mol. Cell. Proteomics, March 1, 2008; 7(3): 546 - 559.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
S.-M. HO, Y.-K. LEUNG, and I. CHUNG
Estrogens and Antiestrogens as Etiological Factors and Therapeutics for Prostate Cancer
Ann. N.Y. Acad. Sci., November 1, 2006; 1089(1): 177 - 193.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. J. Krieg, E. M. Hammond, and A. J. Giaccia
Functional Analysis of p53 Binding under Differential Stresses.
Mol. Cell. Biol., October 1, 2006; 26(19): 7030 - 7045.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. J. Ansell, C. Espinosa-Nicholas, E. M. Curran, B. M. Judy, B. J. Philips, M. Hannink, and D. B. Lubahn
In Vitro and in Vivo Regulation of Antioxidant Response Element-Dependent Gene Expression by Estrogens
Endocrinology, January 1, 2004; 145(1): 311 - 317.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
L. C. Hodges, J. D. Cook, E. K. Lobenhofer, L. Li, L. Bennett, P. R. Bushel, C. M. Aldaz, C. A. Afshari, and C. L. Walker
Tamoxifen Functions As a Molecular Agonist Inducing Cell Cycle-Associated Genes in Breast Cancer Cells
Mol. Cancer Res., February 1, 2003; 1(4): 300 - 311.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H.-C. Huang, T. Nguyen, and C. B. Pickett
Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription
J. Biol. Chem., November 1, 2002; 277(45): 42769 - 42774.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
M. T. Holderman, K. P. Miller, L. J. Dangott, and K. S. Ramos
Identification of Albumin Precursor Protein, Phi AP3, and alpha -Smooth Muscle Actin as Novel Components of Redox Sensing Machinery in Vascular Smooth Muscle Cells
Mol. Pharmacol., May 1, 2002; 61(5): 1174 - 1183.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
K. C. Falkner, J. A. Pinaire, G.-H. Xiao, T. E. Geoghegan, and R. A. Prough
Regulation of the Rat Glutathione S-Transferase A2 Gene by Glucocorticoids: Involvement of Both the Glucocorticoid and Pregnane X Receptors
Mol. Pharmacol., September 1, 2001; 60(3): 611 - 619.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.