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J. Biol. Chem., Vol. 275, Issue 45, 35320-35327, November 10, 2000

This Article Full Text Full Text (PDF) All Versions of this Article: 275/45/35320    most recent M005025200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Recheis, B. Articles by Nimpf, J. Search for Related Content PubMed PubMed Citation Articles by Recheis, B. Articles by Nimpf, J. Social Bookmarking                      What's this?

Chicken Coagulation Factor XIIIA Is Produced by the Theca Externa and Stabilizes the Ovarian Follicular Wall^*

Burgi Recheis, Andreas Osanger, Sabine Haubenwallner, Wolfgang J. Schneider, and Johannes Nimpf

From The Institute of Medical Biochemistry, Department of Molecular Genetics, Biocenter and University of Vienna, Vienna A-1030, Austria

Development of the follicle in egg-laying species such as the chicken is regulated by systemic factors as well as by the highly orchestrated interplay of differentially expressed genes within this organ. Differential mRNA display analysis of defined phases of follicle development resulted in the characterization of coagulation factor XIIIA. It is expressed and produced by cells of the theca externa in a highly regulated manner during distinct growth phases of the follicle. Transcripts for factor XIIIA are already detectable at the beginning of follicle development and peak at the end of phase 2. Protein levels, however, still increase during phase 3, peak shortly after ovulation, and persist until the postovulatory tissue is completely resorbed. Factor XIIIA is secreted as a monomer into the extracellular matrix of the theca externa and is not associated with factor XIIIB as is the case in plasma. Our data suggest that, due to its transglutaminase activity, factor XIIIA stabilizes the follicular wall by cross-linking matrix components. Thus, coagulation factor XIIIA might play a key role in coping with the massive mechanical stress exerted by the large amount of yolk accumulating during the rapid growth phase of the oocyte.

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