HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

J. Biol. Chem., Vol. 275, Issue 48, 37870-37875, December 1, 2000

This Article Full Text Full Text (PDF) All Versions of this Article: 275/48/37870    most recent M007302200v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Soyez, D. Articles by Géraud, G. Search for Related Content PubMed PubMed Citation Articles by Soyez, D. Articles by Géraud, G. Social Bookmarking                      What's this?

L to D Amino Acid Isomerization in a Peptide Hormone Is a Late Post-translational Event Occurring in Specialized Neurosecretory Cells^*

Daniel Soyez^§, Jean-Yves Toullec, Cécile Ollivaux^¶, and Gérard Géraud

From the  Laboratoire Signaux Endocrines et Toxines d'Invertébrés, CNRS EP2028-Univ. Paris 6, Ecole Normale Supérieure, 46 rue d'Ulm, 75005 Paris and  Service d'Imagerie, Institut Jacques Monod, CNRS-Univ. Paris 6 and Univ. P7, 2 place Jussieu, 75251 Paris cedex 05, France.

Modification of the chirality of a single amino acid residue within a peptide chain appears to be novel additional mechanism leading to structural and functional diversification of eukaryotic bioactive peptides. This phenomenon has been studied at the cellular level in a neuroendocrine organ which elaborates a mixture of diastereoisomers of a 72-residue neuropeptide, crustacean hyperglycemic hormone. For the first time, amino acid isomerization has been shown to occur in the perikarya of fully specialized neurosecretory cells, as a late step of the maturation of the hyperglycemic hormone precursor and after propeptide cleavage. The specificity and efficiency of this phenomenon indicates the existence of a new enzyme family involved in the biogenesis of peptide hormones.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

				L. Serrano, E. Grousset, G. Charmantier, and C. Spanings-Pierrot Occurrence of L- and D-Crustacean Hyperglycemic Hormone Isoforms in the Eyestalk X-Organ/Sinus Gland Complex During the Ontogeny of the Crayfish Astacus leptodactylus J. Histochem. Cytochem., September 1, 2004; 52(9): 1129 - 1140. [Abstract] [Full Text] [PDF]

				L. Serrano, G. Blanvillain, D. Soyez, G. Charmantier, E. Grousset, F. Aujoulat, and C. Spanings-Pierrot Putative involvement of crustacean hyperglycemic hormone isoforms in the neuroendocrine mediation of osmoregulation in the crayfish Astacus leptodactylus J. Exp. Biol., March 15, 2003; 206(6): 979 - 988. [Abstract] [Full Text] [PDF]