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J. Biol. Chem., Vol. 275, Issue 48, 38005-38011, December 1, 2000

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Roles of Two Homotetrameric Kinesins in Sea Urchin Embryonic Cell Division^*

Kitty K. Chui, Gregory C. Rogers, Anna M. Kashina, Karen P. Wedaman, David J. Sharp, Duy T. Nguyen, Fred Wilt, and Jonathan M. Scholey^§

From the Section of Molecular and Cellular Biology, University of California, Davis, California 95616 and the  Department of Molecular and Cellular Biology, University of California, Berkeley, California 94720-3200

To improve our understanding of the roles of microtubule cross-linking motors in mitosis, we analyzed two sea urchin embryonic kinesin-related proteins. It is striking to note that both of these proteins behave as homotetramers, but one behaves as a more compact molecule than the other. These observations suggest that these two presumptive motors could cross-link microtubules into bundles with different spacing. Both motors localize to mitotic spindles, and antibody microinjection experiments suggest that they have mitotic functions. Thus, one of these kinesin-related proteins may cross-link spindle microtubules into loose bundles that are "tightened" by the other.

The nucleotide sequence(s) reported in this paper has been submitted to the GenBank^TM/EMBL Data Bank with accession number(s) AF292394 and AF292395.

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