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Originally published In Press as doi:10.1074/jbc.M005457200 on September 7, 2000

J. Biol. Chem., Vol. 275, Issue 49, 38347-38354, December 8, 2000
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Eos and Pegasus, Two Members of the Ikaros Family of Proteins with Distinct DNA Binding Activities*

José PerdomoDagger §, Melissa Holmes, Beng Chong, and Merlin CrossleyDagger ||

From the Dagger  Department of Biochemistry, G08, University of Sydney, Sydney, New South Wales 2006, Australia and the  Centre of Thrombosis and Vascular Research, School of Pathology, University of New South Wales, Sydney, New South Wales 2052, Australia

Members of the Ikaros family of transcription factors, Ikaros, Aiolos, and Helios, are expressed in lymphocytes and have been implicated in controlling lymphoid development. These proteins contain two characteristic clusters of zinc fingers, an N-terminal domain important for DNA recognition, and a C-terminal domain that mediates homo- and heterotypic associations between family members. The conservation of these domains is such that all three proteins recognize related DNA sequences, and all are capable of dimerizing with other family members. Here we describe two additional Ikaros family proteins, Eos and Pegasus. Eos is most highly related to Helios and shares its DNA binding and protein association properties. Pegasus is related to other Ikaros proteins in its C-terminal dimerization domain but contains a divergent N-terminal zinc finger domain. Pegasus self-associates and binds to other family members but recognizes distinct DNA-binding sites. Eos and Pegasus repress the expression of reporter genes containing their recognition elements. Our results suggest that these proteins may associate with previously described Ikaros family proteins in lymphoid cells and play additional roles in other tissues.

* This work was supported by a grant from the University of Sydney Cancer Research Fund (to M. C.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ Supported by an Australian Post-graduate Award.

|| To whom correspondence should be addressed: Dept. of Biochemistry, G08, University of Sydney, NSW 2006, Australia. Tel.: 61-2-9351-2233, Fax: 61-2-9351-4726; E-mail: M.Crossley@ biochem.usyd.edu.au.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
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