JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M004385200 on October 6, 2000

J. Biol. Chem., Vol. 275, Issue 50, 39324-39331, December 15, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/50/39324    most recent
M004385200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Bonini, J. A.
Right arrow Articles by Borowsky, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bonini, J. A.
Right arrow Articles by Borowsky, B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Identification and Characterization of Two G Protein-coupled Receptors for Neuropeptide FF*

James A. BoniniDagger , Kenneth A. Jones, Nika Adham, Carlos Forray, Roman Artymyshyn, Margaret M. Durkin, Kelli E. Smith, Joseph A. Tamm, Lakmal W. Boteju, Parul P. Lakhlani, Rita Raddatz, Wen-Jeng Yao, Kristine L. Ogozalek, Noel Boyle, Evguenia V. Kouranova, Yong Quan, Pierre J. Vaysse, John M. Wetzel, Theresa A. Branchek, Christophe Gerald, and Beth Borowsky

From the Synaptic Pharmaceutical Corporation, Paramus, New Jersey 07652

The central nervous system octapeptide, neuropeptide FF (NPFF), is believed to play a role in pain modulation and opiate tolerance. Two G protein-coupled receptors, NPFF1 and NPFF2, were isolated from human and rat central nervous system tissues. NPFF specifically bound to NPFF1 (Kd = 1.13 nM) and NPFF2 (Kd = 0.37 nM), and both receptors were activated by NPFF in a variety of heterologous expression systems. The localization of mRNA and binding sites of these receptors in the dorsal horn of the spinal cord, the lateral hypothalamus, the spinal trigeminal nuclei, and the thalamic nuclei supports a role for NPFF in pain modulation. Among the receptors with the highest amino acid sequence homology to NPFF1 and NPFF2 are members of the orexin, NPY, and cholecystokinin families, which have been implicated in feeding. These similarities together with the finding that BIBP3226, an anorexigenic Y1 receptor ligand, also binds to NPFF1 suggest a potential role for NPFF1 in feeding. The identification of NPFF1 and NPFF2 will help delineate their roles in these and other physiological functions.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF268898, AF268899, AF268900, and AF268901.

Dagger To whom correspondence should be addressed: Synaptic Pharmaceutical Corp., 215 College Rd., Paramus, NJ 07652. Tel.: 201-261-1331, ext. 733; Fax: 201-261-0623; E-mail: jbonini@synapticcorp.com.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Immunol.Home page
M.-G. Lee, X. Dong, Q. Liu, K. N. Patel, O. H. Choi, B. Vonakis, and B. J. Undem
Agonists of the Mas-Related Gene (Mrgs) Orphan Receptors as Novel Mediators of Mast Cell-Sensory Nerve Interactions
J. Immunol., February 15, 2008; 180(4): 2251 - 2255.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. H. Jhamandas, F. Simonin, J.-J. Bourguignon, and K. H. Harris
Neuropeptide FF and neuropeptide VF inhibit GABAergic neurotransmission in parvocellular neurons of the rat hypothalamic paraventricular nucleus
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2007; 292(5): R1872 - R1880.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. J. David, K. C. Klemenhagen, K. A. Holick, M. D. Saxe, I. Mendez, L. Santarelli, D. A. Craig, H. Zhong, C. J. Swanson, L. G. Hegde, et al.
Efficacy of the MCHR1 Antagonist N-[3-(1-{[4-(3,4-Difluorophenoxy)phenyl]methyl}(4-piperidyl))-4-methylphenyl]-2-methylpropanamide (SNAP 94847) in Mouse Models of Anxiety and Depression following Acute and Chronic Administration Is Independent of Hippocampal Neurogenesis
J. Pharmacol. Exp. Ther., April 1, 2007; 321(1): 237 - 248.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
D. A Bechtold and S. M Luckman
The role of RFamide peptides in feeding
J. Endocrinol., January 1, 2007; 192(1): 3 - 15.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
J. Brill, M. Lee, S. Zhao, R. D. Fernald, and J. R. Huguenard
Chronic valproic acid treatment triggers increased neuropeptide y expression and signaling in rat nucleus reticularis thalami.
J. Neurosci., June 21, 2006; 26(25): 6813 - 6822.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
F. Simonin, M. Schmitt, J.-P. Laulin, E. Laboureyras, J. H. Jhamandas, D. MacTavish, A. Matifas, C. Mollereau, P. Laurent, M. Parmentier, et al.
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia
PNAS, January 10, 2006; 103(2): 466 - 471.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
S. Tunaru, J. Lattig, J. Kero, G. Krause, and S. Offermanns
Characterization of Determinants of Ligand Binding to the Nicotinic Acid Receptor GPR109A (HM74A/PUMA-G)
Mol. Pharmacol., November 1, 2005; 68(5): 1271 - 1280.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Wettschureck and S. Offermanns
Mammalian G Proteins and Their Cell Type Specific Functions
Physiol Rev, October 1, 2005; 85(4): 1159 - 1204.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Pharmacol.Home page
C. Mollereau, H. Mazarguil, J.-M. Zajac, and M. Roumy
Neuropeptide FF (NPFF) Analogs Functionally Antagonize Opioid Activities in NPFF2 Receptor-Transfected SH-SY5Y Neuroblastoma Cells
Mol. Pharmacol., March 1, 2005; 67(3): 965 - 975.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
H Yin, K Ukena, T Ubuka, and K Tsutsui
A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica): identification, expression and binding activity
J. Endocrinol., January 1, 2005; 184(1): 257 - 266.
[Abstract] [Full Text] [PDF]

Home page
 Exp PhysiolHome page
G. J. Dockray
The expanding family of -RFamide peptides and their effects on feeding behaviour
Exp Physiol, May 1, 2004; 89(3): 229 - 235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. M. Nicklous and K. J. Simansky
Neuropeptide FF exerts pro- and anti-opioid actions in the parabrachial nucleus to modulate food intake
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2003; 285(5): R1046 - R1054.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. Engstrom, A. Brandt, S. Wurster, J.-M. Savola, and P. Panula
Prolactin Releasing Peptide Has High Affinity and Efficacy at Neuropeptide FF2 Receptors
J. Pharmacol. Exp. Ther., June 1, 2003; 305(3): 825 - 832.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
M. M. Berglund, P. A. Hipskind, and D. R. Gehlert
Recent Developments in Our Understanding of the Physiological Role of PP-Fold Peptide Receptor Subtypes
Experimental Biology and Medicine, March 1, 2003; 228(3): 217 - 244.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. P. Kukkonen, T. Holmqvist, S. Ammoun, and K. E. O. Akerman
Functions of the orexinergic/hypocretinergic system
Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1567 - C1591.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S.-K. Han, X. Dong, J.-I. Hwang, M. J. Zylka, D. J. Anderson, and M. I. Simon
Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway
PNAS, November 12, 2002; 99(23): 14740 - 14745.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. Lefrere, P. de Coppet, J.-C. Camelin, S. Le Lay, N. Mercier, N. Elshourbagy, A. Bril, I. Berrebi-Bertrand, B. Feve, and S. Krief
Neuropeptide AF and FF Modulation of Adipocyte Metabolism. PRIMARY INSIGHTS FROM FUNCTIONAL GENOMICS AND EFFECTS ON beta -ADRENERGIC RESPONSIVENESS
J. Biol. Chem., October 11, 2002; 277(42): 39169 - 39178.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Q. Liu, X.-M. Guan, W. J. Martin, T. P. McDonald, M. K. Clements, Q. Jiang, Z. Zeng, M. Jacobson, D. L. Williams Jr., H. Yu, et al.
Identification and Characterization of Novel Mammalian Neuropeptide FF-like Peptides That Attenuate Morphine-induced Antinociception
J. Biol. Chem., September 28, 2001; 276(40): 36961 - 36969.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.