JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.C000567200 on October 25, 2000

J. Biol. Chem., Vol. 275, Issue 51, 39855-39859, December 22, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/51/39855    most recent
C000567200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Zhang, H.
Right arrow Articles by Treuter, E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Zhang, H.
Right arrow Articles by Treuter, E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

DAX-1 Functions as an LXXLL-containing Corepressor for Activated Estrogen Receptors*

Hui ZhangDagger , Jane S. Thomsen, Lotta Johansson, Jan-Åke Gustafsson, and Eckardt TreuterDagger §

From the Department of Biosciences at Novum, Karolinska Institute, S-14157 Huddinge, Sweden

We have discovered that the orphan receptor DAX-1 (NROB1) interacts with the estrogen receptors ERalpha and ERbeta . Interaction occurs with ligand-activated ERs in solution and on DNA and is mediated by the unique DAX-1 N-terminal repeat domain. Each of the three repeats contains a leucine-rich receptor-binding motif, known as the LXXLL motif, which is usually found in nuclear receptor coactivators. We have demonstrated that DAX-1 functions as an inhibitor of ER activation in mammalian cells and suggest a mechanism involving two sequential events, occupation of the ligand-induced coactivator-binding surface and subsequent recruitment of corepressors. Accordingly, we propose that DAX-1 itself acts as a corepressor for ERs. Because DAX-1 is coexpressed with ERs in reproductive tissues, these interactions could play significant roles by influencing estrogen signaling pathways. Our results point at functional similarities between DAX-1 and the orphan receptor SHP (NROB2) in that they have acquired features of transcriptional coregulators that are unique for members of the nuclear receptor family.

* This work was supported by the Karo Bio AB and the Swedish Cancer Society.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger These authors contributed equally to this work.

§ To whom correspondence should be addressed: Dept. of Biosciences at Novum, Karolinska Institute, S-14157 Huddinge, Sweden. Tel.: 46 8 608 9160; Fax: 46 6 774 5538; E-mail: eckardt.treuter@cbt.ki.se.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Mol. Endocrinol.Home page
J. Zhou, R. H. Oakley, and J. A. Cidlowski
DAX-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X-Chromosome, Gene 1) Selectively Inhibits Transactivation But Not Transrepression Mediated by the Glucocorticoid Receptor in a LXXLL-Dependent Manner
Mol. Endocrinol., July 1, 2008; 22(7): 1521 - 1534.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
H. Yasumoto, L. Meng, T. Lin, Q. Zhu, and R. Y. L. Tsai
GNL3L inhibits activity of estrogen-related receptor {gamma} by competing for coactivator binding
J. Cell Sci., August 1, 2007; 120(15): 2532 - 2543.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
N. Heldring, A. Pike, S. Andersson, J. Matthews, G. Cheng, J. Hartman, M. Tujague, A. Strom, E. Treuter, M. Warner, et al.
Estrogen Receptors: How Do They Signal and What Are Their Targets
Physiol Rev, July 1, 2007; 87(3): 905 - 931.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
A. A. Verrijn Stuart, G. Ozisik, M. A. de Vroede, J. C. Giltay, R. J. Sinke, T. J. Peterson, R. M. Harris, J. Weiss, and J. L. Jameson
An Amino-Terminal DAX1 (NROB1) Missense Mutation Associated with Isolated Mineralocorticoid Deficiency
J. Clin. Endocrinol. Metab., March 1, 2007; 92(3): 755 - 761.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Saxena, R. Escamilla-Hernandez, L. Little-Ihrig, and A. J. Zeleznik
Liver Receptor Homolog-1 and Steroidogenic Factor-1 Have Similar Actions on Rat Granulosa Cell Steroidogenesis
Endocrinology, February 1, 2007; 148(2): 726 - 734.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
D. Wilhelm, S. Palmer, and P. Koopman
Sex Determination and Gonadal Development in Mammals
Physiol Rev, January 1, 2007; 87(1): 1 - 28.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
G. Benoit, A. Cooney, V. Giguere, H. Ingraham, M. Lazar, G. Muscat, T. Perlmann, J.-P. Renaud, J. Schwabe, F. Sladek, et al.
International Union of Pharmacology. LXVI. Orphan Nuclear Receptors
Pharmacol. Rev., December 1, 2006; 58(4): 798 - 836.
[Abstract] [Full Text] [PDF]

Home page
 Mol Cancer ResHome page
M. Kinsey, R. Smith, and S. L. Lessnick
NR0B1 Is Required for the Oncogenic Phenotype Mediated by EWS/FLI in Ewing's Sarcoma
Mol. Cancer Res., November 1, 2006; 4(11): 851 - 859.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. K. Iyer, Y.-H. Zhang, and E. R. B. McCabe
Dosage-Sensitive Sex Reversal Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1 (DAX1) (NR0B1) and Small Heterodimer Partner (SHP) (NR0B2) Form Homodimers Individually, as Well as DAX1-SHP Heterodimers
Mol. Endocrinol., October 1, 2006; 20(10): 2326 - 2342.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
L. A. Helguero, M. Hedengran Faulds, C. Forster, J.-A. Gustafsson, and L.-A. Haldosen
DAX-1 Expression Is Regulated during Mammary Epithelial Cell Differentiation
Endocrinology, July 1, 2006; 147(7): 3249 - 3259.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. A. Arnold, E. Estebanez-Perpina, M. Togashi, N. Jouravel, A. Shelat, A. C. McReynolds, E. Mar, P. Nguyen, J. D. Baxter, R. J. Fletterick, et al.
Discovery of Small Molecule Inhibitors of the Interaction of the Thyroid Hormone Receptor with Transcriptional Coregulators
J. Biol. Chem., December 30, 2005; 280(52): 43048 - 43055.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
Y.-Y. Park, S.-W. Ahn, H.-J. Kim, J.-M. Kim, I.-K. Lee, H. Kang, and H.-S. Choi
An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERR{gamma}
Nucleic Acids Res., November 28, 2005; 33(21): 6756 - 6768.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
E. De Menis, F. Roncaroli, V. Calvari, V. Chiarini, P. Pauletto, G. Camerino, and N. Cremonini
Corticotroph adenoma of the pituitary in a patient with X-linked adrenal hypoplasia congenita due to a novel mutation of the DAX-1 gene
Eur. J. Endocrinol., August 1, 2005; 153(2): 211 - 215.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Y. Park, J. J. Meeks, G. Raverot, L. E. Pfaff, J. Weiss, G. D. Hammer, and J. L. Jameson
Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development
Development, May 15, 2005; 132(10): 2415 - 2423.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X. Meng, P. Webb, Y.-F. Yang, M. Shuen, A. F. Yousef, J. D. Baxter, J. S. Mymryk, and P. G. Walfish
E1A and a nuclear receptor corepressor splice variant (N-CoRI) are thyroid hormone receptor coactivators that bind in the corepressor mode
PNAS, May 3, 2005; 102(18): 6267 - 6272.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
R. Kumar, A. E. Gururaj, R. K. Vadlamudi, and S. K. Rayala
The Clinical Relevance of Steroid Hormone Receptor Corepressors
Clin. Cancer Res., April 15, 2005; 11(8): 2822 - 2831.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
J. M. R. Moore and R. K. Guy
Coregulator Interactions with the Thyroid Hormone Receptor
Mol. Cell. Proteomics, April 1, 2005; 4(4): 475 - 482.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
Y. Jo and D. M. Stocco
Regulation of Steroidogenesis and Steroidogenic Acute Regulatory Protein in R2C Cells by DAX-1 (Dosage-Sensitive Sex Reversal, Adrenal Hypoplasia Congenita, Critical Region on the X Chromosome, Gene-1)
Endocrinology, December 1, 2004; 145(12): 5629 - 5637.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
C M Klinge, S C Jernigan, K A Mattingly, K E Risinger, and J Zhang
Estrogen response element-dependent regulation of transcriptional activation of estrogen receptors {alpha} and {beta} by coactivators and corepressors
J. Mol. Endocrinol., October 1, 2004; 33(2): 387 - 410.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K.-H. Song, Y.-Y. Park, K. C. Park, C. Y. Hong, J. H. Park, M. Shong, K. Lee, and H.-S. Choi
The Atypical Orphan Nuclear Receptor DAX-1 Interacts with Orphan Nuclear Receptor Nur77 and Represses Its Transactivation
Mol. Endocrinol., August 1, 2004; 18(8): 1929 - 1940.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Hossain, C. Li, and G. F. Saunders
Generation of Two Distinct Functional Isoforms of Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita-Critical Region on the X Chromosome Gene 1 (DAX-1) by Alternative Splicing
Mol. Endocrinol., June 1, 2004; 18(6): 1428 - 1437.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y.-Y. Park, H.-J. Kim, J.-Y. Kim, M.-Y. Kim, K.-H. Song, K. Cheol Park, K.-Y. Yu, M. Shong, K.-H. Kim, and H.-S. Choi
Differential Role of the Loop Region between Helices H6 and H7 within the Orphan Nuclear Receptors Small Heterodimer Partner and DAX-1
Mol. Endocrinol., May 1, 2004; 18(5): 1082 - 1095.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Tujague, J. S. Thomsen, K. Mizuki, C. M. Sadek, and J.-A. Gustafsson
The Focal Adhesion Protein Vinexin {alpha} Regulates the Phosphorylation and Activity of Estrogen Receptor {alpha}
J. Biol. Chem., March 5, 2004; 279(10): 9255 - 9263.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
C. L. Smith and B. W. O'Malley
Coregulator Function: A Key to Understanding Tissue Specificity of Selective Receptor Modulators
Endocr. Rev., February 1, 2004; 25(1): 45 - 71.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
M. H. Faulds, H. Olsen, L. A. Helguero, J.-A. Gustafsson, and L.-A. Haldosen
Estrogen Receptor Functional Activity Changes during Differentiation of Mammary Epithelial Cells
Mol. Endocrinol., February 1, 2004; 18(2): 412 - 421.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Y. Lin, E. M. Resnick, and M. A. Shupnik
Truncated Estrogen Receptor Product-1 Stimulates Estrogen Receptor {alpha} Transcriptional Activity by Titration of Repressor Proteins
J. Biol. Chem., October 3, 2003; 278(40): 38125 - 38131.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
I. U. Agoulnik, W. C. Krause, W. E. Bingman III, H. T. Rahman, M. Amrikachi, G. E. Ayala, and N. L. Weigel
Repressors of Androgen and Progesterone Receptor Action
J. Biol. Chem., August 15, 2003; 278(33): 31136 - 31148.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Lalli and P. Sassone-Corsi
DAX-1, an Unusual Orphan Receptor at the Crossroads of Steroidogenic Function and Sexual Differentiation
Mol. Endocrinol., August 1, 2003; 17(8): 1445 - 1453.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
J. J. Meeks, T. A. Russell, B. Jeffs, I. Huhtaniemi, J. Weiss, and J. L. Jameson
Leydig Cell-Specific Expression of DAX1 Improves Fertility of the Dax1-Deficient Mouse
Biol Reprod, July 1, 2003; 69(1): 154 - 160.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
K. Kawajiri, T. Ikuta, T. Suzuki, M. Kusaka, M. Muramatsu, K. Fujieda, M. Tachibana, and K.-i. Morohashi
Role of the LXXLL-Motif and Activation Function 2 Domain in Subcellular Localization of Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1)
Mol. Endocrinol., June 1, 2003; 17(6): 994 - 1004.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H. Mizusaki, K. Kawabe, T. Mukai, E. Ariyoshi, M. Kasahara, H. Yoshioka, A. Swain, and K.-i. Morohashi
Dax-1 (Dosage-Sensitive Sex Reversal-Adrenal Hypoplasia Congenita Critical Region on the X Chromosome, Gene 1) Gene Transcription Is Regulated by Wnt4 in the Female Developing Gonad
Mol. Endocrinol., April 1, 2003; 17(4): 507 - 519.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
J. J. Meeks, S. E. Crawford, T. A. Russell, K.-i. Morohashi, J. Weiss, and J. L. Jameson
Dax1 regulates testis cord organization during gonadal differentiation
Development, March 1, 2003; 130(5): 1029 - 1036.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. Suzuki, M. Kasahara, H. Yoshioka, K.-i. Morohashi, and K. Umesono
LXXLL-Related Motifs in Dax-1 Have Target Specificity for the Orphan Nuclear Receptors Ad4BP/SF-1 and LRH-1
Mol. Cell. Biol., January 1, 2003; 23(1): 238 - 249.
[Abstract] [Full Text]

Home page
 J. Clin. Endocrinol. Metab.Home page
G. Ozisik, G. Mantovani, J. C. Achermann, L. Persani, A. Spada, J. Weiss, P. Beck-Peccoz, and J. L. Jameson
An Alternate Translation Initiation Site Circumvents an Amino-Terminal DAX1 Nonsense Mutation Leading to a Mild Form of X-Linked Adrenal Hypoplasia Congenita
J. Clin. Endocrinol. Metab., January 1, 2003; 88(1): 417 - 423.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-C. Hu, C.-R. Shyr, W. Che, X.-M. Mu, E. Kim, and C. Chang
Suppression of Estrogen Receptor-mediated Transcription and Cell Growth by Interaction with TR2 Orphan Receptor
J. Biol. Chem., September 6, 2002; 277(37): 33571 - 33579.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
H.-J. Huang, J. D. Norris, and D. P. McDonnell
Identification of a Negative Regulatory Surface within Estrogen Receptor {alpha} Provides Evidence in Support of a Role for Corepressors in Regulating Cellular Responses to Agonists and Antagonists
Mol. Endocrinol., August 1, 2002; 16(8): 1778 - 1792.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Lopez, M. D. Sanchez, W. Shea-Eaton, and M. P. McLean
Estrogen Activates the High-Density Lipoprotein Receptor Gene via Binding to Estrogen Response Elements and Interaction with Sterol Regulatory Element Binding Protein-1A
Endocrinology, June 1, 2002; 143(6): 2155 - 2168.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
E. Holter, N. Kotaja, S. Makela, L. Strauss, S. Kietz, O. A. Janne, J.-A. Gustafsson, J. J. Palvimo, and E. Treuter
Inhibition of Androgen Receptor (AR) Function by the Reproductive Orphan Nuclear Receptor DAX-1
Mol. Endocrinol., March 1, 2002; 16(3): 515 - 528.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
P. Koskimies, J. Levallet, P. Sipila, I. Huhtaniemi, and M. Poutanen
Murine Relaxin-Like Factor Promoter: Functional Characterization and Regulation by Transcription Factors Steroidogenic Factor 1 and DAX-1
Endocrinology, March 1, 2002; 143(3): 909 - 919.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
E. R. B. McCabe
Vulnerability within a Robust Complex System--DAX-1 Mutations and Steroidogenic Axis Development
J. Clin. Endocrinol. Metab., January 1, 2002; 87(1): 41 - 43.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
D. Lopez, W. Shea-Eaton, M. D. Sanchez, and M. P. McLean
DAX-1 Represses the High-Density Lipoprotein Receptor Through Interaction with Positive Regulators Sterol Regulatory Element-Binding Protein-1a and Steroidogenic Factor-1
Endocrinology, December 1, 2001; 142(12): 5097 - 5106.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Yuan, M. L. Lu, T. Li, and S. P. Balk
SRY Interacts with and Negatively Regulates Androgen Receptor Transcriptional Activity
J. Biol. Chem., November 30, 2001; 276(49): 46647 - 46654.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
B. Jeffs, J. J. Meeks, M. Ito, F. A. Martinson, M. M. Matzuk, J. L. Jameson, and L. D. Russell
Blockage of the Rete Testis and Efferent Ductules by Ectopic Sertoli and Leydig Cells Causes Infertility in Dax1-Deficient Male Mice
Endocrinology, October 1, 2001; 142(10): 4486 - 4495.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. Warnmark, T. Almlof, J. Leers, J.-A. Gustafsson, and E. Treuter
Differential Recruitment of the Mammalian Mediator Subunit TRAP220 by Estrogen Receptors ERalpha and ERbeta
J. Biol. Chem., June 22, 2001; 276(26): 23397 - 23404.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. K. Vadlamudi, R.-A. Wang, A. Mazumdar, Y.-s. Kim, J. Shin, A. Sahin, and R. Kumar
Molecular Cloning and Characterization of PELP1, a Novel Human Coregulator of Estrogen Receptor alpha
J. Biol. Chem., October 5, 2001; 276(41): 38272 - 38279.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y.-K. Lee and D. D. Moore
Dual Mechanisms for Repression of the Monomeric Orphan Receptor Liver Receptor Homologous Protein-1 by the Orphan Small Heterodimer Partner
J. Biol. Chem., January 18, 2002; 277(4): 2463 - 2467.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.