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J. Biol. Chem., Vol. 275, Issue 51, 40120-40127, December 22, 2000
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From the Department of Pharmacology, University of Texas
Southwestern Medical Center, Dallas, Texas 75390-9041
Mitogen-activated protein (MAP) kinase cascades
are involved in transmitting signals that are generated at the cell
surface into the cytosol and nucleus and consist of three sequentially acting enzymes: a MAP kinase, an upstream MAP/extracellular
signal-regulated protein kinase (ERK) kinase (MEK), and a MEK kinase
(MEKK). Protein-protein interactions within these cascades provide a
mechanism to control the localization and function of the proteins.
MEKK1 is implicated in activation of the c-Jun N-terminal
kinase/stress-activated protein kinase (JNK/SAPK) and ERK1/2 MAP kinase
pathways. We showed previously that MEKK1 binds directly to JNK/SAPK.
In this study we demonstrate that endogenous MEKK1 binds to endogenous
ERK2, MEK1, and another MEKK level kinase, Raf-1, suggesting that it can assemble all three proteins of the ERK2 MAP kinase module.
MEKK1 Binds Raf-1 and the ERK2 Cascade Components*
,
*
This work was supported by Grants GM56498 and DK34128 from
the National Institutes of Health.The costs of publication of this article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Supported in part by a fellowship from the Perot Family Foundation.
§
Present address: Salk Institute; La Jolla, CA.
¶
To whom correspondence should be addressed: Dept. of
Pharmacology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9041. E-mail:
mcobb@mednet.swmed. edu.
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