JBC Anatrace, Inc.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.M004821200 on September 26, 2000

J. Biol. Chem., Vol. 275, Issue 52, 40782-40787, December 29, 2000
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
275/52/40782    most recent
M004821200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wei, L.-N.
Right arrow Articles by Farooqui, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wei, L.-N.
Right arrow Articles by Farooqui, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Receptor-interacting Protein 140 Directly Recruits Histone Deacetylases for Gene Silencing*

Li-Na WeiDagger §, Xinli HuDagger , Dhyan ChandraDagger , Edward Seto, and Maria FarooquiDagger

From the Dagger  Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota 55455 and the  Molecular Oncology Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612

Receptor-interacting protein 140 (RIP140) encodes a histone deacetylase (HDAC) inhibitor-sensitive repressive activity. Direct interaction of RIP140 with HDAC1 and HDAC3 occurs in vitro and in vivo as demonstrated in co-immunoprecipitation and glutathione S-transferase pull-down experiments. The HDAC-interacting domain of RIP140 is mapped to its N-terminal domain, between amino acids 78 and 303 based upon glutathione S-transferase pull-down experiments. In chromatin immunoprecipitation assays, it is demonstrated that histone deacetylation occurs at the chromatin region of the Gal4 binding sites as a result of Gal4 DNA binding domain-tethered RIP expression. The immunocomplexes of RIP140 from cells transfected with RIP140 and HDAC are able to deacetylate histone proteins in vitro. This study presents the first evidence for RIP140 as a negative coregulator for nuclear receptor actions by directly recruiting histone deacetylases and categorizes RIP140 as a novel negative coregulator that is able to directly interact with HDACs.

* This work was supported by Grant DK54733 from the National Institutes of Health and Grant RPG-99-237-010CNE from the American Cancer Society (to L. N. W).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ To whom correspondence should be addressed: Dept. of Pharmacology, University of Minnesota, 6-120 Jackson Hall, 321 Church St. SE, Minneapolis, MN 55455-0217. Tel.: 612 6259402; Fax: 612 6258408; E-mail: weixx009@maroon.tc.umn.edu.

Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
M. M. Rytinki and J. J. Palvimo
SUMOylation Modulates the Transcription Repressor Function of RIP140
J. Biol. Chem., April 25, 2008; 283(17): 11586 - 11595.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. Herzog, M. Hallberg, A. Seth, A. Woods, R. White, and M. G. Parker
The Nuclear Receptor Cofactor, Receptor-Interacting Protein 140, Is Required for the Regulation of Hepatic Lipid and Glucose Metabolism by Liver X Receptor
Mol. Endocrinol., November 1, 2007; 21(11): 2687 - 2697.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. W. O'Malley
Coregulators: From Whence Came These "Master Genes"
Mol. Endocrinol., May 1, 2007; 21(5): 1009 - 1013.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
P. Gupta, S. W. Park, M. Farooqui, and L.-N. Wei
Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1
Nucleic Acids Res., April 1, 2007; 35(7): 2269 - 2282.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
J. Lopez-Garcia, M. Periyasamy, R. S. Thomas, M. Christian, M. Leao, P. Jat, K. B. Kindle, D. M. Heery, M. G. Parker, L. Buluwela, et al.
ZNF366 is an estrogen receptor corepressor that acts through CtBP and histone deacetylases
Nucleic Acids Res., December 4, 2006; 34(21): 6126 - 6136.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Carascossa, J. Gobinet, V. Georget, A. Lucas, E. Badia, A. Castet, R. White, J.-C. Nicolas, V. Cavailles, and S. Jalaguier
Receptor-Interacting Protein 140 Is a Repressor of the Androgen Receptor Activity
Mol. Endocrinol., July 1, 2006; 20(7): 1506 - 1518.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
A. Castet, A. Herledan, S. Bonnet, S. Jalaguier, J.-M. Vanacker, and V. Cavailles
Receptor-Interacting Protein 140 Differentially Regulates Estrogen Receptor-Related Receptor Transactivation Depending on Target Genes
Mol. Endocrinol., May 1, 2006; 20(5): 1035 - 1047.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Jiang, R. Meyer, K. Kang, C. K. Osborne, J. Wong, and S. Oesterreich
Scaffold Attachment Factor SAFB1 Suppresses Estrogen Receptor {alpha}-Mediated Transcription in Part via Interaction with Nuclear Receptor Corepressor
Mol. Endocrinol., February 1, 2006; 20(2): 311 - 320.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
P. Gupta, M. D. M. Huq, S. A. Khan, N.-P. Tsai, and L.-N. Wei
Regulation of Co-repressive Activity of and HDAC Recruitment to RIP140 by Site-specific Phosphorylation
Mol. Cell. Proteomics, November 1, 2005; 4(11): 1776 - 1784.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. ProteomicsHome page
M. D. M. Huq and L.-N. Wei
Post-translational Modification of Nuclear Co-repressor Receptor-interacting Protein 140 by Acetylation
Mol. Cell. Proteomics, July 1, 2005; 4(7): 975 - 983.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
J. H Steel, R. White, and M. G Parker
Role of the RIP140 corepressor in ovulation and adipose biology
J. Endocrinol., April 1, 2005; 185(1): 1 - 9.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. A. White, M. M. Yore, D. Deng, and M. J. Spinella
Limiting Effects of RIP140 in Estrogen Signaling: POTENTIAL MEDIATION OF ANTI-ESTROGENIC EFFECTS OF RETINOIC ACID
J. Biol. Chem., March 4, 2005; 280(9): 7829 - 7835.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
T. Nakajima, S. Fujino, G. Nakanishi, Y.-S. Kim, and A. M. Jetten
TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4
Nucleic Acids Res., August 9, 2004; 32(14): 4194 - 4204.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
V. Kurtev, R. Margueron, K. Kroboth, E. Ogris, V. Cavailles, and C. Seiser
Transcriptional Regulation by the Repressor of Estrogen Receptor Activity via Recruitment of Histone Deacetylases
J. Biol. Chem., June 4, 2004; 279(23): 24834 - 24843.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
G. Leonardsson, J. H. Steel, M. Christian, V. Pocock, S. Milligan, J. Bell, P.-W. So, G. Medina-Gomez, A. Vidal-Puig, R. White, et al.
Nuclear receptor corepressor RIP140 regulates fat accumulation
PNAS, June 1, 2004; 101(22): 8437 - 8442.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Christian, J. M. A. Tullet, and M. G. Parker
Characterization of Four Autonomous Repression Domains in the Corepressor Receptor Interacting Protein 140
J. Biol. Chem., April 9, 2004; 279(15): 15645 - 15651.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
A. Castet, A. Boulahtouf, G. Versini, S. Bonnet, P. Augereau, F. Vignon, S. Khochbin, S. Jalaguier, and V. Cavailles
Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition
Nucleic Acids Res., April 1, 2004; 32(6): 1957 - 1966.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
S. Sanyal, J. Matthews, D. Bouton, H.-J. Kim, H.-S. Choi, E. Treuter, and J.-A. Gustafsson
Deoxyribonucleic Acid Response Element-Dependent Regulation of Transcription by Orphan Nuclear Receptor Estrogen Receptor-Related Receptor {gamma}
Mol. Endocrinol., February 1, 2004; 18(2): 312 - 325.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
X. Hu, Y. Chen, M. Farooqui, M. C. Thomas, C.-M. Chiang, and L.-N. Wei
Suppressive Effect of Receptor-interacting Protein 140 on Coregulator Binding to Retinoic Acid Receptor Complexes, Histone-modifying Enzyme Activity, and Gene Activation
J. Biol. Chem., January 2, 2004; 279(1): 319 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B.-C. Jeong, C. Y. Hong, S. Chattopadhyay, J. H. Park, E.-Y. Gong, H.-J. Kim, S.-Y. Chun, and K. Lee
Androgen Receptor Corepressor-19 kDa (ARR19), a Leucine-Rich Protein that Represses the Transcriptional Activity of Androgen Receptor through Recruitment of Histone Deacetylase
Mol. Endocrinol., January 1, 2004; 18(1): 13 - 25.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. B. Bowman, J. M. Levorse, R. S. Ingram, and S. M. Tilghman
Functional Characterization of a Testis-Specific DNA Binding Activity at the H19/Igf2 Imprinting Control Region
Mol. Cell. Biol., November 15, 2003; 23(22): 8345 - 8351.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. A. White, M. M. Yore, S. L. Warburton, A. V. Vaseva, E. Rieder, S. J. Freemantle, and M. J. Spinella
Negative Feedback at the Level of Nuclear Receptor Coregulation: SELF-LIMITATION OF RETINOID SIGNALING BY RIP140
J. Biol. Chem., November 7, 2003; 278(45): 43889 - 43892.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
B. Borud, G. Mellgren, J. Lund, and M. Bakke
Cloning and Characterization of a Novel Zinc Finger Protein that Modulates the Transcriptional Activity of Nuclear Receptors
Mol. Endocrinol., November 1, 2003; 17(11): 2303 - 2319.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
H. Tazawa, W. Osman, Y. Shoji, E. Treuter, J.-A. Gustafsson, and J. Zilliacus
Regulation of Subnuclear Localization Is Associated with a Mechanism for Nuclear Receptor Corepression by RIP140
Mol. Cell. Biol., June 15, 2003; 23(12): 4187 - 4198.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
W.-J. Lin, J. Li, Y.-F. Lee, S.-D. Yeh, S. Altuwaijri, J.-H. Ou, and C. Chang
Suppression of Hepatitis B Virus Core Promoter by the Nuclear Orphan Receptor TR4
J. Biol. Chem., March 7, 2003; 278(11): 9353 - 9360.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
C. Teyssier, K. Belguise, F. Galtier, V. Cavailles, and D. Chalbos
Receptor-Interacting Protein 140 Binds c-Jun and Inhibits Estradiol-Induced Activator Protein-1 Activity by Reversing Glucocorticoid Receptor-Interacting Protein 1 Effect
Mol. Endocrinol., February 1, 2003; 17(2): 287 - 299.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
M. J. Spinella, J. S. Kerley, K. A. White, and J. C. Curtin
Retinoid Target Gene Activation during Induced Tumor Cell Differentiation: Human Embryonal Carcinoma as a Model
J. Nutr., January 1, 2003; 133(1): 273S - 276.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
Y. Chen, A. Kerimo, S. Khan, and L.-N. Wei
Real-Time Analysis of Molecular Interaction of Retinoid Receptors and Receptor-Interacting Protein 140 (RIP140)
Mol. Endocrinol., November 1, 2002; 16(11): 2528 - 2537.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. Jin, H. Li, T. Murata, K. Sun, M. Horikoshi, R. Chiu, and K. K. Yokoyama
JDP2, a Repressor of AP-1, Recruits a Histone Deacetylase 3 Complex To Inhibit the Retinoic Acid-Induced Differentiation of F9 Cells
Mol. Cell. Biol., July 1, 2002; 22(13): 4815 - 4826.
[Abstract] [Full Text] [PDF]

Home page
 EndocrinologyHome page
G. Leonardsson, M. A. Jacobs, R. White, R. Jeffery, R. Poulsom, S. Milligan, and M. Parker
Embryo Transfer Experiments and Ovarian Transplantation Identify the Ovary as the Only Site in Which Nuclear Receptor Interacting Protein 1/RIP140 Action Is Crucial for Female Fertility
Endocrinology, February 1, 2002; 143(2): 700 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
N. Vo, C. Fjeld, and R. H. Goodman
Acetylation of Nuclear Hormone Receptor-Interacting Protein RIP140 Regulates Binding of the Transcriptional Corepressor CtBP
Mol. Cell. Biol., September 15, 2001; 21(18): 6181 - 6188.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
P. J. Franco, M. Farooqui, E. Seto, and L.-N. Wei
The Orphan Nuclear Receptor TR2 Interacts Directly with Both Class I and Class II Histone Deacetylases
Mol. Endocrinol., August 1, 2001; 15(8): 1318 - 1328.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Endocrinol.Home page
J. Zilliacus, E. Holter, H. Wakui, H. Tazawa, E. Treuter, and J.-A. Gustafsson
Regulation of Glucocorticoid Receptor Activity by 14-3-3-Dependent Intracellular Relocalization of the Corepressor RIP140
Mol. Endocrinol., April 1, 2001; 15(4): 501 - 511.
[Abstract] [Full Text]

Home page
 J. Biol. Chem.Home page
L.-N. Wei, M. Farooqui, and X. Hu
Ligand-dependent Formation of Retinoid Receptors, Receptor-interacting Protein 140 (RIP140), and Histone Deacetylase Complex Is Mediated by a Novel Receptor-interacting Motif of RIP140
J. Biol. Chem., May 4, 2001; 276(19): 16107 - 16112.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2000 by the American Society for Biochemistry and Molecular Biology.