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J Biol Chem, Vol. 275, Issue 8, 5941-5946, February 25, 2000
From the Laboratory of Molecular Pathology, Department of
Pathology, University of Texas Southwestern Medical Center, Dallas,
Texas 75235-9072, ¶ Department of Molecular Genetics and Virology,
Weizman Institute of Science, Rehovot 76100, Israel, and
A yeast strain harboring a temperature-sensitive
allele of TFB3 (tfb3ts), the 38-kDa
subunit of the RNA polymerase II transcription/nucleotide excision
repair factor TFIIH, was found to be sensitive to ultraviolet (UV)
radiation and defective for nucleotide excision repair in vitro. Interestingly, tfb3ts failed to grow
on medium containing caffeine. A comprehensive pairwise two-hybrid
analysis between yeast TFIIH subunits identified novel interactions
between Rad3 and Tfb3, Tfb4 and Ssl1, as well as Ssl2 and Tfb2. These
interactions have facilitated a more complete model of the structure of
TFIIH and the nucleotide excision repairosome.
Subunit Interactions in Yeast Transcription/Repair Factor
TFIIH
REQUIREMENT FOR Tfb3 SUBUNIT IN NUCLEOTIDE EXCISION REPAIR*
,
,,, and Department of Structural Biology, Stanford University School of
Medicine, Stanford, California 94305
*
These studies were supported by United States Public Health
Service Research Grant CA12420 (to E. C. F.) and by a grant from the
Israel Science Foundation (to O. G.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Fellow of the Jane Coffin Childs Memorial Fund for Medical Research.
§
Present Address: Dept. of Medical Technology, National Cheng-Kung
University, No. 1 University Rd., Tainan, Taiwan.
**
To whom correspondence should be addressed. Tel.: 214-648-4020;
Fax: 214-648-4067; E-mail:
friedberg.errol@pathology.swmed.edu.
Copyright © 2000 by The American Society for Biochemistry and Molecular Biology, Inc.
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