| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
J Biol Chem, Vol. 275, Issue 9, 6051-6054, March 3, 2000
From the Maspin has been shown to inhibit tumor cell
invasion and metastasis in breast tumor cells. Maspin expression was
detected in normal breast and prostate epithelial cells, whereas tumor cells exhibited reduced or no expression. However, the regulatory mechanism of maspin expression remains unknown. We report here a rapid
and robust induction of maspin expression in prostate cancer cells
(LNCaP, DU145, and PC3) and breast tumor cells (MCF7) following wild
type p53 expression from an adenovirus p53 expression vector (AdWTp53).
p53 activates the maspin promoter by binding directly to the p53
consensus-binding site present in the maspin promoter. DNA-damaging
agents and cytotoxic drugs induced endogenous maspin expression in
cells containing the wild type p53. Maspin expression was refractory to
the DNA-damaging agents in cells containing mutant p53. These results,
combined with recent studies of the tumor metastasis suppressor gene
KAI1 and plasminogen activator inhibitor 1 (PAI1), define a new category of molecular targets of p53
that have the potential to negatively regulate tumor invasion and/or metastasis.
ACCELERATED PUBLICATION
p53 Regulates the Expression of the Tumor Suppressor Gene
Maspin*
§,,,
,,§
Department of Surgery, Center for Prostate
Disease Research, Uniformed Services University of the Health
Sciences, Bethesda, Maryland 20814, the Department of
Surgery, Urology Service, Walter Reed Army Medical Center, Washington,
DC 20307, the ** Medical Breast Cancer Section, Medicine Branch,
National Cancer Institute, National Institutes of Health, Bethesda,
Maryland 20892, and the ¶ Laboratory of Cell Biology, National
Institutes of Health, Bethesda, Maryland 20892
*
This work was supported by a grant from the Center for
Prostate Disease Research, which is a program of the Henry M. Jackson Foundation for the Advancement of Military Medicine (Rockville, MD),
funded by the United States Army Medical Research and Materiel Command.The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Current address: Human Gene Therapy Research Institute, Des
Moines, IA 50309.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  D.-F. Lee and M.-C. Hung Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy Clin. Cancer Res., September 15, 2008; 14(18): 5656 - 5662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Sedic, M. Poznic, P. Gehrig, M. Scott, R. Schlapbach, M. Hranjec, G. Karminski-Zamola, K. Pavelic, and S. K. Pavelic Differential antiproliferative mechanisms of novel derivative of benzimidazo[1,2-{alpha}]quinoline in colon cancer cells depending on their p53 status Mol. Cancer Ther., July 1, 2008; 7(7): 2121 - 2132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Woenckhaus, L. Bubendorf, P. Dalquen, J. Foerster, H. Blaszyk, M. Mirlacher, M. Soler, W. Dietmaier, G. Sauter, A. Hartmann, et al. Nuclear and cytoplasmic Maspin expression in primary non-small cell lung cancer J. Clin. Pathol., May 1, 2007; 60(5): 483 - 486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E. Wang, A. Narasanna, C. W. Whitell, F. Y. Wu, D. B. Friedman, and C. L. Arteaga Convergence of p53 and Transforming Growth Factor beta (TGFbeta) Signaling on Activating Expression of the Tumor Suppressor Gene maspin in Mammary Epithelial Cells J. Biol. Chem., February 23, 2007; 282(8): 5661 - 5669. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Friedman, S. E. Wang, C. W. Whitwell, R. M. Caprioli, and C. L. Arteaga Multivariable Difference Gel Electrophoresis and Mass Spectrometry: A Case Study on Transforming Growth Factor-{beta} and ERBB2 Signaling Mol. Cell. Proteomics, January 1, 2007; 6(1): 150 - 169. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Nakagawa, H. Katakura, M. Adachi, K. Takenaka, K. Yanagihara, Y. Otake, H. Wada, and F. Tanaka Maspin Expression and Its Clinical Significance in Non-Small Cell Lung Cancer Ann. Surg. Oncol., November 1, 2006; 13(11): 1517 - 1523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. M. Wise-Draper, H. V. Allen, E. E. Jones, K. B. Habash, H. Matsuo, and S. I. Wells Apoptosis Inhibition by the Human DEK Oncoprotein Involves Interference with p53 Functions Mol. Cell. Biol., October 15, 2006; 26(20): 7506 - 7519. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Yu, S. L. Harris, and A. J. Levine The Regulation of Exosome Secretion: a Novel Function of the p53 Protein. Cancer Res., May 1, 2006; 66(9): 4795 - 4801. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Osada, H. L. Park, Y. Nagakawa, K. Yamashita, A. Fomenkov, M. S. Kim, G. Wu, S. Nomoto, B. Trink, and D. Sidransky Differential Recognition of Response Elements Determines Target Gene Specificity for p53 and p63 Mol. Cell. Biol., July 15, 2005; 25(14): 6077 - 6089. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. H. P. Law, J. A. Irving, A. M. Buckle, K. Ruzyla, M. Buzza, T. A. Bashtannyk-Puhalovich, T. C. Beddoe, K. Nguyen, D. M. Worrall, S. P. Bottomley, et al. The High Resolution Crystal Structure of the Human Tumor Suppressor Maspin Reveals a Novel Conformational Switch in the G-helix J. Biol. Chem., June 10, 2005; 280(23): 22356 - 22364. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Ricciardiello, C. Ceccarelli, G. Angiolini, M. Pariali, P. Chieco, P. Paterini, G. Biasco, G. N. Martinelli, E. Roda, and F. Bazzoli High Thymidylate Synthase Expression in Colorectal Cancer with Microsatellite Instability: Implications for Chemotherapeutic Strategies Clin. Cancer Res., June 1, 2005; 11(11): 4234 - 4240. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Latha, W. Zhang, N. Cella, H. Y. Shi, and M. Zhang Maspin Mediates Increased Tumor Cell Apoptosis upon Induction of the Mitochondrial Permeability Transition Mol. Cell. Biol., March 1, 2005; 25(5): 1737 - 1748. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Hirai, K. Koizumi, S. Haraguchi, T. Hirata, I. Mikami, M. Fukushima, S. Yamagishi, T. Kawashima, D. Okada, K. Shimizu, et al. Prognostic Significance of the Tumor Suppressor Gene Maspin in Non-Small Cell Lung Cancer Ann. Thorac. Surg., January 1, 2005; 79(1): 248 - 253. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Al-Ayyoubi, P. G. W. Gettins, and K. Volz Crystal Structure of Human Maspin, a Serpin with Antitumor Properties: REACTIVE CENTER LOOP OF MASPIN IS EXPOSED BUT CONSTRAINED J. Biol. Chem., December 31, 2004; 279(53): 55540 - 55544. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kim, J. Han, J. Kim, and C. Park Maspin Expression Is Transactivated by p63 and Is Critical for the Modulation of Lung Cancer Progression Cancer Res., October 1, 2004; 64(19): 6900 - 6905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J Schedel, O Distler, M Woenckhaus, R E Gay, B Simmen, B A Michel, U Muller-Ladner, and S Gay Discrepancy between mRNA and protein expression of tumour suppressor maspin in synovial tissue may contribute to synovial hyperplasia in rheumatoid arthritis Ann Rheum Dis, October 1, 2004; 63(10): 1205 - 1211. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Osborne, P. Wilson, and D. Tripathy Oncogenes and Tumor Suppressor Genes in Breast Cancer: Potential Diagnostic and Therapeutic Applications Oncologist, July 1, 2004; 9(4): 361 - 377. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. C. McKay, L. J. Stubbert, C. C. Fowler, J. M. Smith, R. A. Cardamore, and J. C. Spronck Regulation of ultraviolet light-induced gene expression by gene size PNAS, April 27, 2004; 101(17): 6582 - 6586. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Akiyama, C. Maesawa, S. Ogasawara, M. Terashima, and T. Masuda Cell-Type-Specific Repression of the Maspin Gene Is Disrupted Frequently by Demethylation at the Promoter Region in Gastric Intestinal Metaplasia and Cancer Cells Am. J. Pathol., November 1, 2003; 163(5): 1911 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. B. Roninson Tumor Cell Senescence in Cancer Treatment Cancer Res., June 1, 2003; 63(11): 2705 - 2715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. L. Crowley-Weber, C. M. Payne, M. Gleason-Guzman, G. S. Watts, B. Futscher, C. N. Waltmire, C. Crowley, K. Dvorakova, C. Bernstein, M. Craven, et al. Development and molecular characterization of HCT-116 cell lines resistant to the tumor promoter and multiple stress-inducer, deoxycholate Carcinogenesis, December 1, 2002; 23(12): 2063 - 2080. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Sood, M. S. Fletcher, L. M. Gruman, J. E. Coffin, S. Jabbari, Z. Khalkhali-Ellis, N. Arbour, E. A. Seftor, and M. J. C. Hendrix The Paradoxical Expression of Maspin in Ovarian Carcinoma Clin. Cancer Res., September 1, 2002; 8(9): 2924 - 2932. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. W. Kirk, M. Feinsod, R. Favis, R. M. Kliman, and F. Barany Single nucleotide polymorphism seeking long term association with complex disease Nucleic Acids Res., August 1, 2002; 30(15): 3295 - 3311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Zou, W. Zhang, D. Young, M. G. Gleave, P. Rennie, T. Connell, R. Connelly, J. Moul, S. Srivastava, and I. Sesterhenn Maspin Expression Profile in Human Prostate Cancer (CaP) and in Vitro Induction of Maspin Expression by Androgen Ablation Clin. Cancer Res., May 1, 2002; 8(5): 1172 - 1177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kobayashi, F. Okada, N. Fujii, N. Tomita, S. Ito, H. Tazawa, T. Aoyama, S. K. Choi, T. Shibata, H. Fujita, et al. Thymosin-{beta}4 Regulates Motility and Metastasis of Malignant Mouse Fibrosarcoma Cells Am. J. Pathol., March 1, 2002; 160(3): 869 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Lu, G. Magrane, C. Yin, D. N. Louis, J. Gray, and T. Van Dyke Selective Inactivation of p53 Facilitates Mouse Epithelial Tumor Progression without Chromosomal Instability Mol. Cell. Biol., September 1, 2001; 21(17): 6017 - 6030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Y Shi, W. Zhang, R. Liang, S. Abraham, F. S. Kittrell, D. Medina, and M. Zhang Blocking Tumor Growth, Invasion, and Metastasis by Maspin in a Syngeneic Breast Cancer Model Cancer Res., September 1, 2001; 61(18): 6945 - 6951. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Maass, T. Hojo, M. Ueding, J. Lüttges, G. Klöppel, W. Jonat, and K. Nagasaki Expression of the Tumor Suppressor Gene Maspin in Human Pancreatic Cancers Clin. Cancer Res., April 1, 2001; 7(4): 812 - 817. [Abstract] [Full Text]
|
|
|
|
|
|
B.-D. Chang, M. E. Swift, M. Shen, J. Fang, E. V. Broude, and I. B. Roninson Molecular determinants of terminal growth arrest induced in tumor cells by a chemotherapeutic agent PNAS, January 8, 2002; 99(1): 389 - 394. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| All ASBMB Journals | Molecular and Cellular Proteomics |
| Journal of Lipid Research | ASBMB Today |
