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J. Biol. Chem., Vol. 276, Issue 1, 172-178, January 5, 2001
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From the Center for Agricultural Biotechnology and the Department
of Chemistry and Biochemistry, University of Maryland, College Park,
Maryland 20742
As-1-type
cis-elements augment transcription of both nuclear and
pathogen genes in response to stress and defense cues in plants.
Basic/leucine zipper proteins termed "TGA factors" that specifically bind as-1 elements are likely candidates for
mediating these transcription activities. Our earlier work has shown
that 2,4-dichlorophenoxyacetic acid-induced xenobiotic stress enhances trans-activation by a chimeric fusion protein of the yeast
Gal4 binding domain and TGA1a, a TGA factor of tobacco. Here we
demonstrate that xenobiotic stress also enhances the ability of native
TGA1a to bind as-1 and activate transcription of a known
target gene. In addition, the previously identified xenobiotic
stress-responsive domain of TGA1a was found to inhibit this factor's
trans-activation potential by a mechanism that appears to
involve stimulus-reversible interactions with a nuclear repressor
protein. Results from these and other studies can now be placed in the
context of a working model to explain basal and xenobiotic
stress-induced activities of TGA1a through its cognate
cis-acting element.
Regulation of DNA Binding and trans-Activation by a
Xenobiotic Stress-activated Plant Transcription Factor*
*
This work was supported by the University of Maryland
Biotechnology Institute and by Grant MCB-9527364 from the National
Science Foundation (to J. A.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: University of Maryland
Biotechnology Institute, 5115 Plant Sciences Bldg., College Park, MD 20742. Tel.: (301) 405-5353; Fax: (301) 314-9075; E-mail: arias@umbi.umd.edu.
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