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Originally published In Press as doi:10.1074/jbc.C000773200 on January 12, 2001

J. Biol. Chem., Vol. 276, Issue 10, 6889-6892, March 9, 2001
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ACCELERATED PUBLICATION
Physical and Functional Interactions between Zic and Gli Proteins*

Yoshio KoyabuDagger §, Katsunori NakataDagger , Kiyomi MizugishiDagger , Jun ArugaDagger , and Katsuhiko MikoshibaDagger §

From the Dagger  Laboratory for Developmental Neurobiology, RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan and the § Department of Basic Medical Science, Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo 108-8639, Japan

Zic and Gli family proteins are transcription factors that share similar zinc finger domains. Recent studies indicate that Zic and Gli collaborate in neural and skeletal development. We provide evidence that the Zic and Gli proteins physically and functionally interact through their zinc finger domains. Moreover, Gli proteins were translocated to cell nuclei by coexpressed Zic proteins, and both proteins regulated each other's transcriptional activity. Our result suggests that the physical interaction between Zic and Gli is the molecular basis of their antagonistic or synergistic features in developmental contexts and that Zic proteins are potential modulators of the hedgehog-mediated signaling pathway.

* This work was supported by Special Coordination Funds for Promoting Science and Technology, grants from the Japanese Ministry of Education, Science and Culture, Takeda Science Foundation, the Naito Foundation, Senri Life Science Foundation, and the Japan Society for Promotion of Science.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

To whom correspondence should be addressed. Tel.: 81-48-467-9745; Fax: 81-48-467-9744; E-mail; jaruga@brain.riken.go.jp.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.


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