JBC

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.C000916200 on January 10, 2001

J. Biol. Chem., Vol. 276, Issue 11, 7701-7704, March 16, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/11/7701    most recent
C000916200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tam, W. F.
Right arrow Articles by Sen, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tam, W. F.
Right arrow Articles by Sen, R.

ACCELERATED PUBLICATION
Ikappa B Family Members Function by Different Mechanisms*

Winnie F. Tam and Ranjan SenDagger

From the Rosenstiel Basic Medical Sciences Research Center and the Department of Biology, Brandeis University, Waltham, Massachusetts 02454

The Ikappa B family of proteins regulates NF-kappa B-dependent transcription by inhibiting DNA binding and localizing these factors to the cell cytoplasm. Ikappa Balpha does this by shifting the balance between nuclear import of Rel proteins and their export from the nucleus. Here we show that, unlike Ikappa Balpha , Ikappa Bbeta and Ikappa Bepsilon appear to sequester p65 or c-Rel in the cytoplasm by inhibiting nuclear import. Furthermore, because Ikappa Bbeta does not undergo nucleocytoplasmic shuttling, it cannot remove nuclear proteins like Ikappa Balpha does. We conclude that the mechanism of action differs among Ikappa B family members.

* The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger To whom correspondence should be addressed: Rosenstiel Basic Medical Sciences Research Ctr., Brandeis University, 415 South St., Waltham, MA 02454. E-mail: sen@brandeis.edu.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.


This article has been cited by other articles:


Home page
 CarcinogenesisHome page
J. L. Williams, P. Ji, N. Ouyang, X. Liu, and B. Rigas
NO-donating aspirin inhibits the activation of NF-{kappa}B in human cancer cell lines and Min mice
Carcinogenesis, February 1, 2008; 29(2): 390 - 397.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
C. M. Berchtold, Z.-H. Wu, T. T. Huang, and S. Miyamoto
Calcium-Dependent Regulation of NEMO Nuclear Export in Response to Genotoxic Stimuli
Mol. Cell. Biol., January 15, 2007; 27(2): 497 - 509.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Garaude, S. Cherni, S. Kaminski, E. Delepine, C. Chable-Bessia, M. Benkirane, J. Borges, A. Pandiella, M. A. Iniguez, M. Fresno, et al.
ERK5 Activates NF-{kappa}B in Leukemic T Cells and Is Essential for Their Growth In Vivo
J. Immunol., December 1, 2006; 177(11): 7607 - 7617.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Aguilera, V. Fernandez-Majada, J. Ingles-Esteve, V. Rodilla, A. Bigas, and L. Espinosa
Efficient nuclear export of p65-I{kappa}B{alpha} complexes requires 14-3-3 proteins.
J. Cell Sci., September 1, 2006; 119(Pt 17): 3695 - 3704.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
I. Lamsoul, J. Lodewick, S. Lebrun, R. Brasseur, A. Burny, R. B. Gaynor, and F. Bex
Exclusive Ubiquitination and Sumoylation on Overlapping Lysine Residues Mediate NF-{kappa}B Activation by the Human T-Cell Leukemia Virus Tax Oncoprotein
Mol. Cell. Biol., December 1, 2005; 25(23): 10391 - 10406.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
C. Y. Sasaki, T. J. Barberi, P. Ghosh, and D. L. Longo
Phosphorylation of RelA/p65 on Serine 536 Defines an I{kappa}B{alpha}-independent NF-{kappa}B Pathway
J. Biol. Chem., October 14, 2005; 280(41): 34538 - 34547.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
E. Hertlein, J. Wang, K. J. Ladner, N. Bakkar, and D. C. Guttridge
RelA/p65 Regulation of I{kappa}B{beta}
Mol. Cell. Biol., June 15, 2005; 25(12): 4956 - 4968.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
I M Verma
Nuclear factor (NF)-{kappa}B proteins: therapeutic targets
Ann Rheum Dis, November 1, 2004; 63(suppl_2): ii57 - ii61.
[Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
Y. Chen, S. Vallee, J. Wu, D. Vu, J. Sondek, and G. Ghosh
Inhibition of NF-{kappa}B Activity by I{kappa}B{beta} in Association with {kappa}B-Ras
Mol. Cell. Biol., April 1, 2004; 24(7): 3048 - 3056.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
E. A. Albrecht, A. M. Chinnaiyan, S. Varambally, C. Kumar-Sinha, T. R. Barrette, J. V. Sarma, and P. A. Ward
C5a-Induced Gene Expression in Human Umbilical Vein Endothelial Cells
Am. J. Pathol., March 1, 2004; 164(3): 849 - 859.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
N. Kishore, C. Sommers, S. Mathialagan, J. Guzova, M. Yao, S. Hauser, K. Huynh, S. Bonar, C. Mielke, L. Albee, et al.
A Selective IKK-2 Inhibitor Blocks NF-{kappa}B-dependent Gene Expression in Interleukin-1{beta}-stimulated Synovial Fibroblasts
J. Biol. Chem., August 29, 2003; 278(35): 32861 - 32871.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Malek, D.-B. Huang, T. Huxford, S. Ghosh, and G. Ghosh
X-ray Crystal Structure of an I{kappa}B{beta}{middle dot}NF-{kappa}B p65 Homodimer Complex
J. Biol. Chem., June 13, 2003; 278(25): 23094 - 23100.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Chen, J. Wu, and G. Ghosh
{kappa}B-Ras Binds to the Unique Insert within the Ankyrin Repeat Domain of I{kappa}B{beta} and Regulates Cytoplasmic Retention of I{kappa}B{beta}{middle dot}NF-{kappa}B Complexes
J. Biol. Chem., June 13, 2003; 278(25): 23101 - 23106.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Biol.Home page
G. Biswas, H. K. Anandatheerthavarada, M. Zaidi, and N. G. Avadhani
Mitochondria to nucleus stress signaling: a distinctive mechanism of NF{kappa}B/Rel activation through calcineurin-mediated inactivation of I{kappa}B{beta}
J. Cell Biol., May 12, 2003; 161(3): 507 - 519.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. K. Moorthy and G. Ghosh
p105{middle dot}Ikappa Bgamma and Prototypical Ikappa Bs Use a Similar Mechanism to Bind but a Different Mechanism to Regulate the Subcellular Localization of NF-kappa B
J. Biol. Chem., January 3, 2003; 278(1): 556 - 566.
[Abstract] [Full Text] [PDF]

Home page
 J. Histochem. Cytochem.Home page
D. Tapalaga, G. Tiegs, and S. Angermuller
NF{kappa}B and Caspase-3 Activity in Apoptotic Hepatocytes of Galactosamine-sensitized Mice Treated with TNF{alpha}
J. Histochem. Cytochem., December 1, 2002; 50(12): 1599 - 1609.
[Abstract] [Full Text] [PDF]

Home page
 ScienceHome page
A. Hoffmann, A. Levchenko, M. L. Scott, and D. Baltimore
The Ikappa B-NF-kappa B Signaling Module: Temporal Control and Selective Gene Activation
Science, November 8, 2002; 298(5596): 1241 - 1245.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
T. T. Huang, S. L. Feinberg, S. Suryanarayanan, and S. Miyamoto
The Zinc Finger Domain of NEMO Is Selectively Required for NF-{kappa}B Activation by UV Radiation and Topoisomerase Inhibitors
Mol. Cell. Biol., August 15, 2002; 22(16): 5813 - 5825.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-H. Lee and M. Hannink
Characterization of the Nuclear Import and Export Functions of Ikappa Bepsilon
J. Biol. Chem., June 21, 2002; 277(26): 23358 - 23366.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Pizzi, F. Goffi, F. Boroni, M. Benarese, S. E. Perkins, H.-C. Liou, and P. Spano
Opposing Roles for NF-kappa B/Rel Factors p65 and c-Rel in the Modulation of Neuron Survival Elicited by Glutamate and Interleukin-1beta
J. Biol. Chem., May 31, 2002; 277(23): 20717 - 20723.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
M. Davis, A. Hatzubai, J. S. Andersen, E. Ben-Shushan, G. Z. Fisher, A. Yaron, A. Bauskin, F. Mercurio, M. Mann, and Y. Ben-Neriah
Pseudosubstrate regulation of the SCFbeta -TrCP ubiquitin ligase by hnRNP-U
Genes & Dev., February 15, 2002; 16(4): 439 - 451.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
W. F. Tam, W. Wang, and R. Sen
Cell-Specific Association and Shuttling of I{kappa}B{alpha} Provides a Mechanism for Nuclear NF-{kappa}B in B Lymphocytes
Mol. Cell. Biol., July 15, 2001; 21(14): 4837 - 4846.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Malek, Y. Chen, T. Huxford, and G. Ghosh
Ikappa Bbeta , but Not Ikappa Balpha , Functions as a Classical Cytoplasmic Inhibitor of NF-kappa B Dimers by Masking Both NF-kappa B Nuclear Localization Sequences in Resting Cells
J. Biol. Chem., November 21, 2001; 276(48): 45225 - 45235.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.