JBC PeproTech; Our Business is Cytokines!

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.C000838200 on January 31, 2001

J. Biol. Chem., Vol. 276, Issue 12, 8631-8634, March 23, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/12/8631    most recent
C000838200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hayashi, M.
Right arrow Articles by Lee, J.-D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayashi, M.
Right arrow Articles by Lee, J.-D.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

ACCELERATED PUBLICATION
BMK1 Mediates Growth Factor-induced Cell Proliferation through Direct Cellular Activation of Serum and Glucocorticoid-inducible Kinase*

Masaaki Hayashi, Richard I. Tapping, Ta-Hsiang Chao, Jeng-Fan Lo, Charles C. King, Young YangDagger , and Jiing-Dwan Lee§

From the Department of Immunology, The Scripps Research Institute, La Jolla, California 92037 and Dagger  the R. W. Johnson Pharmaceutical Research Institute, San Diego, California 92121

Activation of the mammalian mitogen-activated protein kinase known as BMK1 is required for growth factor-induced cell proliferation. To understand the mechanism by which BMK1 mediates this cellular response, this kinase was used as bait in a yeast two-hybrid-based library screening. Here, we report the identification of serum and glucocorticoid-inducible kinase (SGK) as a cellular protein that physically interacts with BMK1. During growth factor-induced cell stimulation, BMK1 activates SGK by phosphorylation at serine 78. This BMK1-mediated phosphorylation event is necessary for the activation of SGK and, more importantly, for cell proliferation induced by growth factors.

* This work was supported by Grant CA79871 from the National Institutes of Health and a grant from the American Heart Association. This publication was made possible by funds received from the Cancer Research Fund, under Interagency Agreement 97-12013 (University of California Contract 98-00924V) with the Department of Health Services, Cancer Research Program. Mention of trade name, proprietary product, or specific equipment does not constitute a guaranty or warranty by the Department of Health Services nor does it imply approval to the exclusion of other products. The views expressed herein represent those of the authors and do not necessarily represent the position of the State of California, Department of Health Services.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ To whom correspondence should be addressed. E-mail: jdlee@scripps.edu.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Biol. Chem.Home page
L. Belova, D. R. Brickley, B. Ky, S. K. Sharma, and S. D. Conzen
Hsp90 Regulates the Phosphorylation and Activity of Serum- and Glucocorticoid-regulated Kinase-1
J. Biol. Chem., July 4, 2008; 283(27): 18821 - 18831.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
F. Dorado, S. Velasco, A. Esparis-Ogando, M. Pericacho, A. Pandiella, J. Silva, J. M. Lopez-Novoa, and A. Rodriguez-Barbero
The mitogen-activated protein kinase Erk5 mediates human mesangial cell activation
Nephrol. Dial. Transplant., June 21, 2008; (2008) gfn333v1.
[Abstract] [Full Text] [PDF]

Home page
 J Biomol ScreenHome page
K. Nakamura, J. S. Zawistowski, M. A. Hughes, J. Z. Sexton, L.-A. Yeh, G. L. Johnson, and J. E. Scott
Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer Assay for Measurement of Phox/Bem1p (PB1) Domain Heterodimerization
J Biomol Screen, June 1, 2008; 13(5): 396 - 405.
[Abstract] [PDF]

Home page
 CirculationHome page
B. C. Berk
Atheroprotective Signaling Mechanisms Activated by Steady Laminar Flow in Endothelial Cells
Circulation, February 26, 2008; 117(8): 1082 - 1089.
[Full Text] [PDF]

Home page
 Protein Sci.Home page
B. Zhao, R. Lehr, A. M. Smallwood, T. F. Ho, K. Maley, T. Randall, M. S. Head, K. K. Koretke, and C. G. Schnackenberg
Crystal structure of the kinase domain of serum and glucocorticoid-regulated kinase 1 in complex with AMP PNP
Protein Sci., December 1, 2007; 16(12): 2761 - 2769.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. A. Martel, D. Michael, G. Fejes-Toth, and A. Naray-Fejes-Toth
Melanophilin, a novel aldosterone-induced gene in mouse cortical collecting duct cells
Am J Physiol Renal Physiol, September 1, 2007; 293(3): F904 - F913.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. C. Pao, J. A. McCormick, H. Li, J. Siu, C. Govaerts, V. Bhalla, R. Soundararajan, and D. Pearce
NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions
Am J Physiol Renal Physiol, June 1, 2007; 292(6): F1741 - F1750.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Yan, C. L. Miller, and J.-i. Abe
Regulation of Phosphodiesterase 3 and Inducible cAMP Early Repressor in the Heart
Circ. Res., March 2, 2007; 100(4): 489 - 501.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. G. Fuster, I. A. Bobulescu, J. Zhang, J. Wade, and O. W. Moe
Characterization of the regulation of renal Na+/H+ exchanger NHE3 by insulin
Am J Physiol Renal Physiol, February 1, 2007; 292(2): F577 - F585.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. Lang, C. Bohmer, M. Palmada, G. Seebohm, N. Strutz-Seebohm, and V. Vallon
(Patho)physiological Significance of the Serum- and Glucocorticoid-Inducible Kinase Isoforms.
Physiol Rev, October 1, 2006; 86(4): 1151 - 1178.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
C. U Onyimba, N. Vijapurapu, S J. Curnow, P. Khosla, P. M Stewart, P. I Murray, E. A Walker, and S. Rauz
Characterisation of the prereceptor regulation of glucocorticoids in the anterior segment of the rabbit eye.
J. Endocrinol., August 1, 2006; 190(2): 483 - 493.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
K. Lister, D. J. Autelitano, A. Jenkins, R. D. Hannan, and K. E. Sheppard
Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: A possible role for SGK1
Cardiovasc Res, June 1, 2006; 70(3): 555 - 565.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Kondoh, K. Terasawa, H. Morimoto, and E. Nishida
Regulation of nuclear translocation of extracellular signal-regulated kinase 5 by active nuclear import and export mechanisms.
Mol. Cell. Biol., March 1, 2006; 26(5): 1679 - 1690.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
K. Nakamura, M. T. Uhlik, N. L. Johnson, K. M. Hahn, and G. L. Johnson
PB1 Domain-Dependent Signaling Complex Is Required for Extracellular Signal-Regulated Kinase 5 Activation.
Mol. Cell. Biol., March 1, 2006; 26(6): 2065 - 2079.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B.-e Xu, S. Stippec, A. Lazrak, C.-L. Huang, and M. H. Cobb
WNK1 Activates SGK1 by a Phosphatidylinositol 3-Kinase-dependent and Non-catalytic Mechanism
J. Biol. Chem., October 7, 2005; 280(40): 34218 - 34223.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Meng, Y. Yamagiwa, S. Taffetani, J. Han, and T. Patel
IL-6 activates serum and glucocorticoid kinase via p38{alpha} mitogen-activated protein kinase pathway
Am J Physiol Cell Physiol, October 1, 2005; 289(4): C971 - C981.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
B.-e Xu, S. Stippec, P.-Y. Chu, A. Lazrak, X.-J. Li, B.-H. Lee, J. M. English, B. Ortega, C.-L. Huang, and M. H. Cobb
WNK1 activates SGK1 to regulate the epithelial sodium channel
PNAS, July 19, 2005; 102(29): 10315 - 10320.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
X. Carvajal-Vergara, S. Tabera, J. C. Montero, A. Esparis-Ogando, R. Lopez-Perez, G. Mateo, N. Gutierrez, M. Parmo-Cabanas, J. Teixido, J. F. San Miguel, et al.
Multifunctional role of Erk5 in multiple myeloma
Blood, June 1, 2005; 105(11): 4492 - 4499.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Beloueche-Babari, L. E. Jackson, N. M.S. Al-Saffar, P. Workman, M. O. Leach, and S. M. Ronen
Magnetic Resonance Spectroscopy Monitoring of Mitogen-Activated Protein Kinase Signaling Inhibition
Cancer Res., April 15, 2005; 65(8): 3356 - 3363.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Zhou and P. M. Snyder
Nedd4-2 Phosphorylation Induces Serum and Glucocorticoid-regulated Kinase (SGK) Ubiquitination and Degradation
J. Biol. Chem., February 11, 2005; 280(6): 4518 - 4523.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Vallon, P. Wulff, D. Y. Huang, J. Loffing, H. Volkl, D. Kuhl, and F. Lang
Role of Sgk1 in salt and potassium homeostasis
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2005; 288(1): R4 - R10.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Lang
Surfing the lipid bilayer: how basolateral insulin receptors regulate Na+ channels in the apical cell membrane. Focus on "Real-time three-dimensional imaging of lipid signal transduction: apical membrane insertion of epithelial Na+ channels"
Am J Physiol Cell Physiol, December 1, 2004; 287(6): C1539 - C1540.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
N. Trochen, S. Ganapathipillai, P. Ferrari, B. M. Frey, and F. J. Frey
Low prevalence of nonconservative mutations of serum and glucocorticoid-regulated kinase (SGK1) gene in hypertensive and renal patients
Nephrol. Dial. Transplant., October 1, 2004; 19(10): 2499 - 2504.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G.-X. Wang, C. McCrudden, Y.-P. Dai, B. Horowitz, J. R. Hume, and I. A. Yamboliev
Hypotonic activation of volume-sensitive outwardly rectifying chloride channels in cultured PASMCs is modulated by SGK
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H533 - H544.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. S. Polhill, S. Saad, P. Poronnik, G. R. Fulcher, and C. A. Pollock
Short-term peaks in glucose promote renal fibrogenesis independently of total glucose exposure
Am J Physiol Renal Physiol, August 1, 2004; 287(2): F268 - F273.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
Z. Raviv, E. Kalie, and R. Seger
MEK5 and ERK5 are localized in the nuclei of resting as well as stimulated cells, while MEKK2 translocates from the cytosol to the nucleus upon stimulation
J. Cell Sci., May 1, 2004; 117(9): 1773 - 1784.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Ghannam, A. Takeda, T. Camarata, M. A. Moore, A. Viale, and N. R. Yaseen
The Oncogene Nup98-HOXA9 Induces Gene Transcription in Myeloid Cells
J. Biol. Chem., January 9, 2004; 279(2): 866 - 875.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Yoo, B. Y. Kim, C. Campo, L. Nance, A. King, D. Maouyo, and P. A. Welling
Cell Surface Expression of the ROMK (Kir 1.1) Channel Is Regulated by the Aldosterone-induced Kinase, SGK-1, and Protein Kinase A
J. Biol. Chem., June 13, 2003; 278(25): 23066 - 23075.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. L. L. Leong, A. C. Maiyar, B. Kim, B. A. O'Keeffe, and G. L. Firestone
Expression of the Serum- and Glucocorticoid-inducible Protein Kinase, Sgk, Is a Cell Survival Response to Multiple Types of Environmental Stress Stimuli in Mammary Epithelial Cells
J. Biol. Chem., February 14, 2003; 278(8): 5871 - 5882.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S.-W. Kim, M. Hayashi, J.-F. Lo, Y. Yang, J.-S. Yoo, and J.-D. Lee
ADP-ribosylation Factor 4 Small GTPase Mediates Epidermal Growth Factor Receptor-dependent Phospholipase D2 Activation
J. Biol. Chem., January 17, 2003; 278(4): 2661 - 2668.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. W. Pearson and M. H. Cobb
Cell Condition-dependent Regulation of ERK5 by cAMP
J. Biol. Chem., December 6, 2002; 277(50): 48094 - 48098.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. D. Stockand
New ideas about aldosterone signaling in epithelia
Am J Physiol Renal Physiol, April 1, 2002; 282(4): F559 - F576.
[Abstract] [Full Text] [PDF]

Home page
 J. Cell Sci.Home page
C. Shelly and R. Herrera
Activation of SGK1 by HGF, Rac1 and integrin-mediated cell adhesion in MDCK cells: PI-3K-dependent and -independent pathways
J. Cell Sci., January 5, 2002; 115(9): 1985 - 1993.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
F. Lang and P. Cohen
Regulation and Physiological Roles of Serum- and Glucocorticoid-Induced Protein Kinase Isoforms
Sci. Signal., November 13, 2001; 2001(108): re17 - re17.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.