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Originally published In Press as doi:10.1074/jbc.M008391200 on November 8, 2000

J. Biol. Chem., Vol. 276, Issue 12, 8639-8642, March 23, 2001
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Octamer Transcription Factors Up-regulate the Expression of CCR5, a Coreceptor for HIV-1 Entry*

Masako MoriuchiDagger and Hiroyuki MoriuchiDagger §

From the Laboratory of Immunoregulation, NIAID, National Institutes of Health, Bethesda, Maryland 20892 and the Division of Medical Virology, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Medical Sciences, Nagasaki 852-8523, Japan

T cell activation can induce expression of CCR5, a major coreceptor for macrophage-tropic (R5) human immunodeficiency virus type 1 (HIV-1). Here we report that overexpression of the Oct-2 transcription factor and octamer coactivator BOB.1/OBF/OCA-B, both of which are induced in T cells following T cell receptor signaling, synergistically up-regulates CCR5 promoter activity via interaction with an octamer motif on the promoter. We also show that the octamer transcription factors can increase cell surface expression of CCR5 and fusogenicity of the cells with R5 HIV-1 Env. These results suggest that octamer transcription factors may play a critical role in the induction of CCR5 expression on, and thereby susceptibility to, R5 HIV-1 of T cells following antigenic stimulation.

* This work was supported in part by grants provided by a Research for the Future Program (JSPS-RFTF97L00705) of the Japan Society for the Promotion of Science and by the Ichiro Kanehara Foundation.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

Dagger The two authors contributed equally to this work.

§ To whom correspondence should be addressed: Dept. of Pediatrics, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. Tel.: 81-95-849-7297; Fax: 81-95-849-7301; E-mail: hiromori@net.nagasaki-u.ac.jp.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.


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