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Originally published In Press as doi:10.1074/jbc.M011314200 on January 11, 2001

J. Biol. Chem., Vol. 276, Issue 16, 13427-13432, April 20, 2001
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Reciprocal Regulatory Interaction between Human Herpesvirus 8 and Human Immunodeficiency Virus Type 1*

Li-Min HuangDagger §, Miao-Fen ChaoDagger , Mao-Yuan Chen, Hsiu-ming Shih||, Yu-Ping ChiangDagger , Che-Yen Chuang, and Chin-Yun LeeDagger

From the Departments of Dagger  Pediatrics and  Internal Medicine, National Taiwan University Hospital and || Division of Molecular and Genomic Medicine, National Health Research Institutes, Taipei 100, Taiwan

Human herpesvirus 8 (HHV8) is the primary viral etiologic agent in Kaposi's sarcoma (KS). However, individuals dually infected with both HHV8 and human immunodeficiency virus type 1 (HIV-1) show an enhanced prevalence of KS when compared with those singularly infected with HHV8. Host immune suppression conferred by HIV infection cannot wholly explain this increased presentation of KS. To better understand how HHV8 and HIV-1 might interact directly in the pathogenesis of KS, we queried for potential regulatory interactions between the two viruses. Here, we report that HHV8 and HIV-1 reciprocally up-regulate the gene expression of each other. We found that the KIE2 immediate-early gene product of HHV8 interacted synergistically with Tat in activating expression from the HIV-1 long terminal repeat. On the other hand, HIV-1 encoded Tat and Vpr proteins increased intracellular HHV8-specific expression. These results provide molecular insights correlating coinfection with HHV8 and HIV-1 with an unusually high incidence of KS.


* This project was supported by a grant (NSC 88-2314-B002-139) from National Science Council, Republic of China, a grant from the Center for Disease Control, Department of Health, Taiwan, and a grant from the China Medical College Hospital, Taichung, Taiwan.The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ To whom correspondence should be addressed: Dept. of Pediatrics, National Taiwan University Hospital, 7 Chung-Shan South Rd., Taipei 100, Taiwan. Tel.: 886-2-2312-3456 ext. 5139; Fax: 886-2-2393-4749; E-mail: lmhuang@ha.mc.ntu.edu.tw.


Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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