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Originally published In Press as doi:10.1074/jbc.M009889200 on January 25, 2001

J. Biol. Chem., Vol. 276, Issue 17, 13689-13694, April 27, 2001
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A Naturally Processed Rat Major Histocompatibility Complex Class I-associated Viral Peptide as Target Structure of Borna Disease Virus-specific CD8+ T Cells*

Oliver PlanzDagger §, Tilman Dumrese||, Silke HülpüschDagger , Markus Schirle, Stefan Stevanovic, and Lothar StitzDagger

From the Dagger  Institut für Immunologie, Bundesforschungsanstalt für Viruskrankheiten der Tiere and  Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, 72076 Tübingen, Germany

The first naturally processed peptide synthesized by a virus and recognized by classical CD8+ T cells in association with the RT1.Al major histocompatibility complex class I molecule of the Lewis rat is reported. Borna disease virus-specific CD8+ T cells recognize syngeneic target cells pulsed with peptides extracted from Borna disease virus-infected cells. The predicted peptide sequence ASYAQMTTY from the viral p40 protein coeluted with the cytotoxic T-lymphocyte-reactive fraction was identified among natural ligands by tandem mass spectrometry. Numerous naturally processed peptides derived from intracellular bacteria, viruses, or tumors and recognized by CD8+ T cells of man and mice are known, leading to a better understanding of cellular immune mechanisms against pathogens in these two species. In contrast, for the rat little information exists with regard to the function and role of CD8+ T cells as part of their cellular immune defense system. This first naturally processed viral epitope in the rat contributes to the understanding of the rat cellular immune response and might trigger the identification of more cytotoxic T-lymphocyte epitopes in this animal.

* This work was supported by Deutsche Forschungsgemeinschaft Grants Pl 256/1-1 (to O. P. and L. S.) and Sti 72/2-2 (to L. S. and O. P.).The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked "advertisement" in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

§ To whom correspondence should be addressed: Institut für Immunologie, Bundesforschungsanstalt für Viruskrankheiten der Tiere, Paul-Ehrlich-Str. 28, 72076 Tübingen, Germany. Tel.: 49 7071 967 254; Fax: 49 7071 967 105; E-mail: oliver.planz@tue.bfav.de.

|| Present address: Universitätsspital Zürich, Dept. of Pathology, Inst. of Experimental Immunology, Schmelzbergstr. 12, CH-8091 Zürich, Switzerland.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
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