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J. Biol. Chem., Vol. 276, Issue 19, 16528-16533, May 11, 2001
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From the RNA polymerase II elongation factor ELL was
recently purified from rat liver as a component of a multiprotein
complex containing ELL and three ELL-associated
proteins (EAPs) of ~45 (EAP45), ~30 (EAP30), and ~20
(EAP20) kDa (Shilatifard, A. (1998) J. Biol. Chem.
273, 11212-11217). Cloning of cDNA encoding the EAP30 protein revealed that it shares significant sequence similarity with the product of the Saccharomyces cerevisiae SNF8 gene (Schmidt,
A. E., Miller, T., Schmidt, S. L., Shiekhattar, R., and
Shilatifard, A. (1999) J. Biol. Chem. 274, 21981-21985), which is required for efficient derepression of
glucose-repressed genes. Here we report the cloning of cDNAs
encoding the EAP45 and EAP20 proteins. In addition, we identify the
S. cerevisiae VPS36 and YJR102c genes as
potential orthologs of EAP45 and EAP20 and show
that they are previously uncharacterized SNF genes with
properties very similar to SNF8.
Cloning and Characterization of ELL-associated Proteins EAP45 and
EAP20
A ROLE FOR YEAST EAP-LIKE PROTEINS IN REGULATION OF GENE
EXPRESSION BY GLUCOSE*
§,§¶,¶,
,,¶,,,¶**, and§§
Program in Molecular and Cell Biology,
Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, the ¶ Howard Hughes Medical Institute, Oklahoma City, Oklahoma
73104, the ** Department of Biochemistry and Molecular Biology,
University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
73190, and the Edward A. Doisy Department of Biochemistry, St.
Louis University School of Medicine, Saint Louis, Missouri 63104
*
This work was supported in part by American Cancer
Society Grant RP69921801 (to A. S.) and by National Institutes of
Health Grant R37-GM41628 and a grant to the Oklahoma Medical Research Foundation by the H. A. and Mary K. Chapman Charitable Trust (to R. C. C. and J. W. C.).The costs of publication of this
article were defrayed in part by the
payment of page charges. The article must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
Associate investigator of the Howard Hughes Medical Institute.
§§
An Edward Mallinckrodt, Jr., Young Investigator. To whom
correspondence should be addressed. Tel.: 314-577-8137; Fax:
314-268-5737; E-mail: shilatia@slu.edu.
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