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J. Biol. Chem., Vol. 276, Issue 2, 1660-1664, January 12, 2001
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From the Departments of We report identification of interleukin (IL)-17E,
a novel member of the IL-17 family of cytokines. IL-17E is a ligand for the recently identified protein termed EVI27/IL-17BR, which we term
IL-17 receptor homolog 1 (IL-17Rh1) in light of the multiple reported
ligand-receptor relationships. Murine EVI27 was identified through its
location at a common site of retroviral integration in BXH2 murine
myeloid leukemias. IL-17Rh1 shows highest level expression in kidney
with moderate expression in multiple other organs, whereas IL-17E
mRNA was detected at very low levels in several peripheral tissues.
IL-17E induces activation of NF- The nucleotide sequence(s) reported in this paper has been submitted to the GenBankTM/EMBL Data Bank with accession number(s) AF305200.
IL-17E, a Novel Proinflammatory Ligand for the IL-17 Receptor
Homolog IL-17Rh1*
,,,,,,,
Molecular Biology,
§ Protein Chemistry, and ¶ Bioinformatics, Genentech
Inc., San Francisco, California 94080
B and stimulates production of the
proinflammatory chemokine IL-8.
*
The costs of publication of this
article were defrayed in part by the
payment of page charges. The article
must therefore be hereby marked
"advertisement" in
accordance with 18 U.S.C. Section
1734 solely to indicate this fact.
To whom correspondence should be addressed: 1 DNA Way South,
San Francisco, CA 94080. Tel.: 650-225-8996; Fax: 650-225-6497; E-mail: nico@gene.com.
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