JBC Advanced Peptides, Inc.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Originally published In Press as doi:10.1074/jbc.C000880200 on March 9, 2001

J. Biol. Chem., Vol. 276, Issue 20, 17479-17483, May 18, 2001
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
276/20/17479    most recent
C000880200v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fukumoto, S.
Right arrow Articles by Lee, M.-E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fukumoto, S.
Right arrow Articles by Lee, M.-E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Akt Participation in the Wnt Signaling Pathway through Dishevelled*

Shinya FukumotoDagger , Chung-Ming HsiehDagger , Koji MaemuraDagger , Matthew D. LayneDagger , Shaw-Fang YetDagger , Kyung-Han Lee, Takashi Matsui, Anthony Rosenzweig, William G. Taylor||, Jeffrey S. Rubin||, Mark A. PerrellaDagger **Dagger Dagger , and Mu-En LeeDagger dagger

Dagger  Cardiovascular and ** Pulmonary and Critical Care Divisions, Department of Medicine, Brigham and Women's Hospital and the  Cardiovascular Research Center and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02115 and the || Laboratory of Cellular and Molecular Biology, Division of Basic Sciences, NCI, National Institutes of Health, Bethesda, Maryland 20892

Inactivation of glycogen synthase kinase 3beta (GSK3beta ) and the resulting stabilization of free beta -catenin are critical steps in the activation of Wnt target genes. While Akt regulates GSK3alpha /beta in the phosphatidylinositide 3-OH kinase signaling pathway, its role in Wnt signaling is unknown. Here we report that expression of Wnt or Dishevelled (Dvl) increased Akt activity. Activated Akt bound to the Axin-GSK3beta complex in the presence of Dvl, phosphorylated GSK3beta and increased free beta -catenin levels. Furthermore, in Wnt-overexpressing PC12 cells, dominant-negative Akt decreased free beta -catenin and derepressed nerve growth factor-induced differentiation. Therefore, Akt acts in association with Dvl as an important regulator of the Wnt signaling pathway.

* This study was supported in part by National Institutes of Health Grants HL57977 (to S.-F. Y.) and HL60788 and GM53249 (to M. A. P.).

This manuscript is dedicated to the memories of Arthur Mu-En Lee and Edgar Haber.

dagger Deceased on April 10, 2000.

Dagger Dagger To whom correspondence should be addressed: Pulmonary Div., Dept. of Medicine, Brigham and Women's Hospital, 75 Francis St., Thorn Bldg., Rm. TH1133, Boston, MA 02115. Tel.: 617-732-6809; Fax: 617-582-6148; E-mail: mperrella@rics.bwh.harvard.edu.

Copyright © 2001 by The American Society for Biochemistry and Molecular Biology, Inc.
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Infect. Immun.Home page
J. L. Larabee, K. DeGiusti, J. L. Regens, and J. D. Ballard
Bacillus anthracis Edema Toxin Activates Nuclear Glycogen Synthase Kinase 3{beta}
Infect. Immun., November 1, 2008; 76(11): 4895 - 4904.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Hoogeboom, M. A. G. Essers, P. E. Polderman, E. Voets, L. M. M. Smits, and B. M. Th. Burgering
Interaction of FOXO with {beta}-Catenin Inhibits {beta}-Catenin/T Cell Factor Activity
J. Biol. Chem., April 4, 2008; 283(14): 9224 - 9230.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Z. Liu and J. F. Habener
Glucagon-like Peptide-1 Activation of TCF7L2-dependent Wnt Signaling Enhances Pancreatic Beta Cell Proliferation
J. Biol. Chem., March 28, 2008; 283(13): 8723 - 8735.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Knobloch, I. Schmitz, K. Gotz, K. Schulze-Osthoff, and U. Ruther
Thalidomide Induces Limb Anomalies by PTEN Stabilization, Akt Suppression, and Stimulation of Caspase-Dependent Cell Death
Mol. Cell. Biol., January 15, 2008; 28(2): 529 - 538.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
S. Rao, I. B. Lobov, J. E. Vallance, K. Tsujikawa, I. Shiojima, S. Akunuru, K. Walsh, L. E. Benjamin, and R. A. Lang
Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch
Development, December 15, 2007; 134(24): 4449 - 4458.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Surg. Oncol.Home page
H.-T. Xu, Q. Wei, Y. Liu, L.-H. Yang, S.-D. Dai, Y. Han, J.-H. Yu, N. Liu, and E.-H. Wang
Overexpression of Axin Downregulates TCF-4 and Inhibits the Development of Lung Cancer
Ann. Surg. Oncol., November 1, 2007; 14(11): 3251 - 3259.
[Abstract] [Full Text] [PDF]

Home page
 Sci SignalHome page
T. Force, K. Woulfe, W. J. Koch, and R. Kerkela
Molecular Scaffolds Regulate Bidirectional Crosstalk Between Wnt and Classical Seven-Transmembrane Domain Receptor Signaling Pathways
Sci. Signal., July 31, 2007; 2007(397): pe41 - pe41.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S Ripka, A Konig, M Buchholz, M Wagner, B Sipos, G Kloppel, J Downward, T. Gress, and P Michl
WNT5A--target of CUTL1 and potent modulator of tumor cell migration and invasion in pancreatic cancer
Carcinogenesis, June 1, 2007; 28(6): 1178 - 1187.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. Knobloch, J. D. Shaughnessy Jr., and U. Ruther
Thalidomide induces limb deformities by perturbing the Bmp/Dkk1/Wnt signaling pathway
FASEB J, May 1, 2007; 21(7): 1410 - 1421.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
V. A.M. van de Schans, S. W.M. van den Borne, A. E. Strzelecka, B. J.A. Janssen, J. L.J. van der Velden, R. C.J. Langen, A. Wynshaw-Boris, J. F.M. Smits, and W. M. Blankesteijn
Interruption of Wnt Signaling Attenuates the Onset of Pressure Overload-Induced Cardiac Hypertrophy
Hypertension, March 1, 2007; 49(3): 473 - 480.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Fujii, L. You, Z. Xu, K. Uematsu, J. Shan, B. He, I. Mikami, L. R. Edmondson, G. Neale, J. Zheng, et al.
An Antagonist of Dishevelled Protein-Protein Interaction Suppresses {beta}-Catenin-Dependent Tumor Cell Growth
Cancer Res., January 15, 2007; 67(2): 573 - 579.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
I. Shiojima and K. Walsh
Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathway
Genes & Dev., December 15, 2006; 20(24): 3347 - 3365.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
A. Haegebarth, W. Bie, R. Yang, S. E. Crawford, V. Vasioukhin, E. Fuchs, and A. L. Tyner
Protein tyrosine kinase 6 negatively regulates growth and promotes enterocyte differentiation in the small intestine.
Mol. Cell. Biol., July 1, 2006; 26(13): 4949 - 4957.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
W. G. Aschenbach, R. C. Ho, K. Sakamoto, N. Fujii, Y. Li, Y.-B. Kim, M. F. Hirshman, and L. J. Goodyear
Regulation of Dishevelled and beta-catenin in rat skeletal muscle: an alternative exercise-induced GSK-3beta signaling pathway
Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E152 - E158.
[Abstract] [Full Text] [PDF]

Home page
 JNCI J Natl Cancer InstHome page
S. Grosch, T. J. Maier, S. Schiffmann, and G. Geisslinger
Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.
J Natl Cancer Inst, June 7, 2006; 98(11): 736 - 747.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Almeida, L. Han, T. Bellido, S. C. Manolagas, and S. Kousteni
Wnt Proteins Prevent Apoptosis of Both Uncommitted Osteoblast Progenitors and Differentiated Osteoblasts by {beta}-Catenin-dependent and -independent Signaling Cascades Involving Src/ERK and Phosphatidylinositol 3-Kinase/AKT
J. Biol. Chem., December 16, 2005; 280(50): 41342 - 41351.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
S. Dihlmann, M. Kloor, C. Fallsehr, and M. von Knebel Doeberitz
Regulation of AKT1 expression by beta-catenin/Tcf/Lef signaling in colorectal cancer cells
Carcinogenesis, September 1, 2005; 26(9): 1503 - 1512.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
H. Zhao, Y. Cui, J. Dupont, H. Sun, L. Hennighausen, and S. Yakar
Overexpression of the Tumor Suppressor Gene Phosphatase and Tensin Homologue Partially Inhibits Wnt-1-Induced Mammary Tumorigenesis
Cancer Res., August 1, 2005; 65(15): 6864 - 6873.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. T. Naito, H. Akazawa, H. Takano, T. Minamino, T. Nagai, H. Aburatani, and I. Komuro
Phosphatidylinositol 3-Kinase-Akt Pathway Plays a Critical Role in Early Cardiomyogenesis by Regulating Canonical Wnt Signaling
Circ. Res., July 22, 2005; 97(2): 144 - 151.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
B. C. Mak, H. L. Kenerson, L. D. Aicher, E. A. Barnes, and R. S. Yeung
Aberrant {beta}-Catenin Signaling in Tuberous Sclerosis
Am. J. Pathol., July 1, 2005; 167(1): 107 - 116.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. Street, A. Macdonald, C. McCormick, and M. Harris
Hepatitis C Virus NS5A-Mediated Activation of Phosphoinositide 3-Kinase Results in Stabilization of Cellular {beta}-Catenin and Stimulation of {beta}-Catenin-Responsive Transcription
J. Virol., April 15, 2005; 79(8): 5006 - 5016.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Sinha, Z. Wang, K. L. Ruchalski, J. S. Levine, S. Krishnan, W. Lieberthal, J. H. Schwartz, and S. C. Borkan
Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors
Am J Physiol Renal Physiol, April 1, 2005; 288(4): F703 - F713.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. Cappuccio, A. Calderone, C. L. Busceti, F. Biagioni, F. Pontarelli, V. Bruno, M. Storto, G. T. Terstappen, G. Gaviraghi, F. Fornai, et al.
Induction of Dickkopf-1, a Negative Modulator of the Wnt Pathway, Is Required for the Development of Ischemic Neuronal Death
J. Neurosci., March 9, 2005; 25(10): 2647 - 2657.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
C. Skurk, H. Maatz, E. Rocnik, A. Bialik, T. Force, and K. Walsh
Glycogen-Synthase Kinase3{beta}/{beta}-Catenin Axis Promotes Angiogenesis Through Activation of Vascular Endothelial Growth Factor Signaling in Endothelial Cells
Circ. Res., February 18, 2005; 96(3): 308 - 318.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Q. Tian, M. C. Feetham, W. A. Tao, X. C. He, L. Li, R. Aebersold, and L. Hood
Proteomic analysis identifies that 14-3-3{zeta} interacts with {beta}-catenin and facilitates its activation by Akt
PNAS, October 26, 2004; 101(43): 15370 - 15375.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Liu and S. R. Farmer
Regulating the Balance between Peroxisome Proliferator-activated Receptor {gamma} and {beta}-Catenin Signaling during Adipogenesis: A GLYCOGEN SYNTHASE KINASE 3{beta} PHOSPHORYLATION-DEFECTIVE MUTANT OF {beta}-CATENIN INHIBITS EXPRESSION OF A SUBSET OF ADIPOGENIC GENES
J. Biol. Chem., October 22, 2004; 279(43): 45020 - 45027.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
A. Rochat, A. Fernandez, M. Vandromme, J.-P. Moles, T. Bouschet, G. Carnac, and N. J. C. Lamb
Insulin and Wnt1 Pathways Cooperate to Induce Reserve Cell Activation in Differentiation and Myotube Hypertrophy
Mol. Biol. Cell, October 1, 2004; 15(10): 4544 - 4555.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
A. Aulehla and B. G. Herrmann
Segmentation in vertebrates: clock and gradient finally joined
Genes & Dev., September 1, 2004; 18(17): 2060 - 2067.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
J. A. McCormick, Y. Feng, K. Dawson, M. J. Behne, B. Yu, J. Wang, A. W. Wyatt, G. Henke, F. Grahammer, T. M. Mauro, et al.
Targeted Disruption of the Protein Kinase SGK3/CISK Impairs Postnatal Hair Follicle Development
Mol. Biol. Cell, September 1, 2004; 15(9): 4278 - 4288.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
J. Shackelford and J. S. Pagano
Tumor Viruses and Cell Signaling Pathways: Deubiquitination versus Ubiquitination
Mol. Cell. Biol., June 15, 2004; 24(12): 5089 - 5093.
[Full Text] [PDF]

Home page
 Mol. Cell. Biol.Home page
D. Papadopoulou, M. W. Bianchi, and M. Bourouis
Functional Studies of Shaggy/Glycogen Synthase Kinase 3 Phosphorylation Sites in Drosophila melanogaster
Mol. Cell. Biol., June 1, 2004; 24(11): 4909 - 4919.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. Xie, D. Yin, X. Tong, J. O'Kelly, A. Mori, C. Miller, K. Black, D. Gui, J. W. Said, and H. P. Koeffler
Cyr61 Is Overexpressed in Gliomas and Involved in Integrin-Linked Kinase-Mediated Akt and {beta}-Catenin-TCF/Lef Signaling Pathways
Cancer Res., March 15, 2004; 64(6): 1987 - 1996.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
J. A. Morrison, A. J. Klingelhutz, and N. Raab-Traub
Epstein-Barr Virus Latent Membrane Protein 2A Activates {beta}-Catenin Signaling in Epithelial Cells
J. Virol., November 15, 2003; 77(22): 12276 - 12284.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
S. J. Grille, A. Bellacosa, J. Upson, A. J. Klein-Szanto, F. van Roy, W. Lee-Kwon, M. Donowitz, P. N. Tsichlis, and L. Larue
The Protein Kinase Akt Induces Epithelial Mesenchymal Transition and Promotes Enhanced Motility and Invasiveness of Squamous Cell Carcinoma Lines
Cancer Res., May 1, 2003; 63(9): 2172 - 2178.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Haq, A. Michael, M. Andreucci, K. Bhattacharya, P. Dotto, B. Walters, J. Woodgett, H. Kilter, and T. Force
Stabilization of beta -catenin by a Wnt-independent mechanism regulates cardiomyocyte growth
PNAS, April 15, 2003; 100(8): 4610 - 4615.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
B. C. Mak, K.-I. Takemaru, H. L. Kenerson, R. T. Moon, and R. S. Yeung
The Tuberin-Hamartin Complex Negatively Regulates beta -Catenin Signaling Activity
J. Biol. Chem., February 14, 2003; 278(8): 5947 - 5951.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
P. Dufourcq, T. Couffinhal, J. Ezan, L. Barandon, C. Moreau, D. Daret, and C. Duplaa
FrzA, a Secreted Frizzled Related Protein, Induced Angiogenic Response
Circulation, December 10, 2002; 106(24): 3097 - 3103.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K. A. Longo, J. A. Kennell, M. J. Ochocinska, S. E. Ross, W. S. Wright, and O. A. MacDougald
Wnt Signaling Protects 3T3-L1 Preadipocytes from Apoptosis through Induction of Insulin-like Growth Factors
J. Biol. Chem., October 4, 2002; 277(41): 38239 - 38244.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Santos, J. M. Paramio, A. Bravo, A. Ramirez, and J. L. Jorcano
The Expression of Keratin K10 in the Basal Layer of the Epidermis Inhibits Cell Proliferation and Prevents Skin Tumorigenesis
J. Biol. Chem., May 17, 2002; 277(21): 19122 - 19130.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Zhang, W.-J. Qiu, S. C. Chan, J. Han, X. He, and S.-C. Lin
Casein Kinase I and Casein Kinase II Differentially Regulate Axin Function in Wnt and JNK Pathways
J. Biol. Chem., May 10, 2002; 277(20): 17706 - 17712.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Ch. Papasozomenos and A. Shanavas
Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau : Implications for Alzheimer's disease
PNAS, January 17, 2002; (2002) 32646799.
[Abstract] [Full Text] [PDF]

Home page
 CarcinogenesisHome page
H. K. Roy, B. F. Olusola, D. L. Clemens, W. J. Karolski, A. Ratashak, H. T. Lynch, and T. C. Smyrk
AKT proto-oncogene overexpression is an early event during sporadic colon carcinogenesis
Carcinogenesis, January 1, 2002; 23(1): 201 - 205.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. M. Ballou, P.-Y. Tian, H.-Y. Lin, Y.-P. Jiang, and R. Z. Lin
Dual Regulation of Glycogen Synthase Kinase-3beta by the alpha 1A-Adrenergic Receptor
J. Biol. Chem., October 26, 2001; 276(44): 40910 - 40916.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Ch. Papasozomenos and A. Shanavas
Testosterone prevents the heat shock-induced overactivation of glycogen synthase kinase-3beta but not of cyclin-dependent kinase 5 and c-Jun NH2-terminal kinase and concomitantly abolishes hyperphosphorylation of tau : Implications for Alzheimer's disease
PNAS, February 5, 2002; 99(3): 1140 - 1145.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 All ASBMB Journals   Molecular and Cellular Proteomics 
 Journal of Lipid Research   ASBMB Today 
Copyright © 2001 by the American Society for Biochemistry and Molecular Biology.